Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in the Treatment of Neurological Disorders

Alpha-asarone Improves Cognitive Function of APP/PS1 Mice and Reducing Aβ42, P-tau and Neuroinflammation, and Promoting Neuron Survival in the Hippocampus

(2021) Lili Zeng et al.   NEUROSCIENCE

GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer’s disease

(2021) Joan Jiménez-Balado et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

(2021) Hui-Zhi Long et al.   Frontiers in Pharmacology

β-Asarone Ameliorates β-Amyloid–Induced Neurotoxicity in PC12 Cells by Activating P13K/Akt/Nrf2 Signaling Pathway

(2021) Miaomiao Meng et al.   Frontiers in Pharmacology

Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC

(2021) Pierpaolo Risiglione et al.   Biomolecules

Cell Death via Lipid Peroxidation and Protein Aggregation Diseases

(2021) Katsuya Iuchi et al.   Biology-Basel

Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives

(2021) Rengasamy Balakrishnan et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress and the Pathophysiology and Symptom Profile of Schizophrenia Spectrum Disorders

(2021) Alex J. Murray et al.   Frontiers in Psychiatry

Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress

(2021) Anamaria Jurcau   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Effect of Alpha-asarone on the Rats Model of Cerebral Ischemia–Reperfusion Stroke via Ameliorating Glial Activation and Autophagy

(2021) Kun Zhang et al.   NEUROSCIENCE

Emerging Potential of Naturally Occurring Autophagy Modulator against Neurodegeneration

(2020) Md. Ataur Rahman et al.   CURRENT PHARMACEUTICAL DESIGN

β-Asarone Inhibits Amyloid-β by Promoting Autophagy in a Cell Model of Alzheimer's Disease

(2020) Nanbu Wang et al.   Frontiers in Pharmacology

Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates

(2020) Hyungsun Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

β‑asarone modulates Beclin‑1, LC3 and p62 expression to attenuate Aβ40 and Aβ42 levels in APP/PS1 transgenic mice with Alzheimer's disease

(2020) Minzhen Deng et al.   Molecular Medicine Reports

Comorbidities of epilepsy in low and middle-income countries: systematic review and meta-analysis

(2020) Aline Muhigwa et al.   Scientific Reports

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein

(2020) Mónica Gómez-Benito et al.   Frontiers in Pharmacology

Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study

(2020) Vineet Sharma et al.   Journal of Clinical Medicine

β-Asarone Exerts Antioxidative Effects on H2O2-Stimulated PC12 Cells by Activating Nrf2/HO-1 Pathway

(2020) Xinxin Hei et al.   NEUROCHEMICAL RESEARCH

Plant-Derived Antioxidants Protect the Nervous System From Aging by Inhibiting Oxidative Stress

(2020) Xiaoji Cui et al.   Frontiers in Aging Neuroscience

α‐Asarone, β‐asarone, and γ‐asarone: Current status of toxicological evaluation

(2020) Thomas Uebel et al.   JOURNAL OF APPLIED TOXICOLOGY

Natural compounds modulate the autophagy with potential implication of stroke

(2020) Anil Ahsan et al.   Acta Pharmaceutica Sinica B

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models

(2019) Hayate Javed et al.   Frontiers in Pharmacology

β-Asarone Regulates ER Stress and Autophagy Via Inhibition of the PERK/CHOP/Bcl-2/Beclin-1 Pathway in 6-OHDA-Induced Parkinsonian Rats

(2019) Baile Ning et al.   NEUROCHEMICAL RESEARCH

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved

(2019) Eftychia Vasili et al.   Frontiers in Molecular Neuroscience

Anti-inflammatory treatment with β-asarone improves impairments in social interaction and cognition in MK-801 treated mice

(2019) Xi Xiao et al.   BRAIN RESEARCH BULLETIN

Asarone and metformin delays experimentally induced hepatocellular carcinoma in diabetic milieu

(2019) Bhrigu Kumar Das et al.   LIFE SCIENCES

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Aβ, Tau, and α-Synuclein aggregation and integrated role of PARK2 in the regulation and clearance of toxic peptides

(2019) Dhiraj Kumar et al.   NEUROPEPTIDES

Asarones from Acori Tatarinowii Rhizoma stimulate expression and secretion of neurotrophic factors in cultured astrocytes

(2019) Kelly Y.C. Lam et al.   NEUROSCIENCE LETTERS

β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway

(2019) Haiying Dong et al.   Experimental and Therapeutic Medicine

Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

Chemical Compositions, In-vitro Antioxidant, Anti-microbial, Anti-inflammatory and Cytotoxic Activities of Essential Oil of Acorus calamus L. Rhizome from North-East India

(2019) Rikraj Loying et al.   Journal of Essential Oil Bearing Plants

Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling

(2019) Yuanbo Wu et al.   MITOCHONDRION

Anti-Amyloidogenic Effects of Asarone Derivatives From Perilla frutescens Leaves against Beta-Amyloid Aggregation and Nitric Oxide Production

(2019) Lee et al.   MOLECULES

Pharmacological Targeting of Microglial Activation: New Therapeutic Approach

(2019) Cai-Yun Liu et al.   Frontiers in Cellular Neuroscience

Effect of α-asarone on ethanol-induced learning and memory impairment in mice and its underlying mechanism

(2019) Qinqing Li et al.   LIFE SCIENCES

Alpha-asarone improves cognitive function of aged rats by alleviating neuronal excitotoxicity via GABAA receptors

(2019) Yu Chen et al.   NEUROPHARMACOLOGY

Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

(2019) William J. Powers et al.   STROKE

Anti-inflammatory and central and peripheral anti-nociceptive activities of α-asarone through the inhibition of TNF-α production, leukocyte recruitment and iNOS expression, and participation of the adenosinergic and opioidergic systems

(2019) Aline Aparecida Saldanha et al.   INFLAMMOPHARMACOLOGY

α-Asarone Alleviated Chronic Constriction Injury–Induced Neuropathic Pain Through Inhibition of Spinal Endoplasmic Reticulum Stress in an Liver X Receptor–Dependent Manner

(2018) Yulong Gui et al.   ANESTHESIA AND ANALGESIA

β-asarone induces cell apoptosis, inhibits cell proliferation and decreases migration and invasion of glioma cells

(2018) Nanbu Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Alpha-asarone attenuates depression-like behavior in nicotine-withdrawn mice: Evidence for the modulation of hippocampal pCREB levels during nicotine-withdrawal

(2018) Ranjithkumar Chellian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases

(2018) Minee L. Choi et al.   FEBS Journal

Anticonvulsant activities of α-asaronol (( E )-3′-hydroxyasarone), an active constituent derived from α-asarone

(2018) Xirui He et al.   Pharmacological Reports

Oral Administration of α-Asarone Promotes Functional Recovery in Rats With Spinal Cord Injury

(2018) Min-Jae Jo et al.   Frontiers in Pharmacology

β-Asarone Inhibits Neuronal Apoptosis via the CaMKII/CREB/Bcl-2 Signaling Pathway in an in vitro Model and AβPP/PS1 Mice

(2018) Gang Wei et al.   JOURNAL OF ALZHEIMERS DISEASE

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors

(2018) Md. Jakaria et al.   Frontiers in Molecular Neuroscience

PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

(2018) Karina Sánchez-Alegría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Positive effects of α-asarone on transplanted neural progenitor cells in a murine model of ischemic stroke

(2018) Hong Ju Lee et al.   PHYTOMEDICINE

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review)

(2017) Jing Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Metabolic Dysfunction and Oxidative Stress in Epilepsy

(2017) Jennifer Pearson-Smith et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis

(2017) Makoto Naoi et al.   JOURNAL OF NEURAL TRANSMISSION

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Endoplasmic reticulum stress and inflammation in the central nervous system

(2017) Neil T. Sprenkle et al.   Molecular Neurodegeneration

The protective effect of the Vacha rhizome extract on chronic stress-induced immunodeficiency in rat

(2017) H. N. Sarjan et al.   PHARMACEUTICAL BIOLOGY

Pharmacology and toxicology of α- and β-Asarone: A review of preclinical evidence

(2017) Ranjithkumar Chellian et al.   PHYTOMEDICINE

α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy

(2017) Sin-Hye Park et al.   Oncotarget

Intranasal delivery of α-asarone to the brain with lactoferrin-modified mPEG-PLA nanoparticles prepared by premix membrane emulsification

(2017) Linmei Pan et al.   Drug Delivery and Translational Research

α-Asarone Attenuates Cognitive Deficit in a Pilocarpine-Induced Status Epilepticus Rat Model via a Decrease in the Nuclear Factor-κB Activation and Reduction in Microglia Neuroinflammation

(2017) Hui-juan Liu et al.   Frontiers in Neurology

Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

(2017) Panchanan Maiti et al.   Translational Neurodegeneration

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Asarone from Acori Tatarinowii Rhizome prevents oxidative stress-induced cell injury in cultured astrocytes: A signaling triggered by Akt activation

(2017) Kelly Y. C. Lam et al.   PLoS One

β-asarone increases MEF2D and TH levels and reduces α-synuclein level in 6-OHDA-induced rats via regulating the HSP70/MAPK/MEF2D/Beclin-1 pathway: Chaperone-mediated autophagy activation, macroautophagy inhibition and HSP70 up-expression

(2016) Liping Huang et al.   BEHAVIOURAL BRAIN RESEARCH

Beta-asarone protects against MPTP-induced Parkinson’s disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression

(2016) Qi-Shun Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery

(2016) Shital Lungare et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dietary compound α-asarone alleviates ER stress-mediated apoptosis in 7β-hydroxycholesterol-challenged macrophages

(2016) Sin-Hye Park et al.   MOLECULAR NUTRITION & FOOD RESEARCH

β-Asarone Inhibits IRE1/XBP1 Endoplasmic Reticulum Stress Pathway in 6-OHDA-Induced Parkinsonian Rats

(2016) Baile Ning et al.   NEUROCHEMICAL RESEARCH

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

Neurogenesis-Promoting Natural Product α-Asarone Modulates Morphological Dynamics of Activated Microglia

(2016) Qing Cai et al.   Frontiers in Cellular Neuroscience

Biphasic Effects of α-Asarone on Immobility in the Tail Suspension Test: Evidence for the Involvement of the Noradrenergic and Serotonergic Systems in Its Antidepressant-Like Activity

(2016) Ranjithkumar Chellian et al.   Frontiers in Pharmacology

Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology

(2016) John P. M. Finberg et al.   Frontiers in Pharmacology

Asarone from Acori Tatarinowii Rhizoma Potentiates the Nerve Growth Factor-Induced Neuronal Differentiation in Cultured PC12 Cells: A Signaling Mediated by Protein Kinase A

(2016) Kelly Y. C. Lam et al.   PLoS One

β-Asarone Rescues Pb-Induced Impairments of Spatial Memory and Synaptogenesis in Rats

(2016) Qian-Qian Yang et al.   PLoS One

A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation

(2015) Jianxin Mao et al.   AGING CELL

Effect of Beta-Asarone on Impairment of Spatial Working Memory and Apoptosis in the Hippocampus of Rats Exposed to Chronic Corticosterone Administration

(2015) Bombi Lee et al.   Biomolecules & Therapeutics

Diagnosis and management of acute ischemic stroke: speed is critical

(2015) Tapuwa D. Musuka et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

β-asarone from Acorus gramineus alleviates depression by modulating MKP-1

(2015) Y.R. Sun et al.   GENETICS AND MOLECULAR RESEARCH

α-Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTP-induced behavioral deficits in a mouse model of Parkinson's disease

(2015) Byung-Wook Kim et al.   NEUROPHARMACOLOGY

Dynamic changes of five neurotransmitters and their related enzymes in various rat tissues following β-asarone and levodopa co-administration

(2015) LIPING HUANG et al.   Experimental and Therapeutic Medicine

α-Asarone Ameliorates Memory Deficit in Lipopolysaccharide-Treated Mice via Suppression of Pro-Inflammatory Cytokines and Microglial Activation

(2014) Jung-Won Shin et al.   Biomolecules & Therapeutics

Arterial Ischemic Stroke in Children: Risk Factors and Etiologies

(2014) Adam L. Numis et al.   Current Neurology and Neuroscience Reports

Distribution of α-asarone in brain following three different routes of administration in rats

(2014) Jin Lu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells

(2014) Zhongfeng Xue et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

β-Asarone (cis-2,4,5-trimethoxy-1-allyl phenyl), attenuates pro-inflammatory mediators by inhibiting NF-κB signaling and the JNK pathway in LPS activated BV-2 microglia cells

(2014) Hyung-Woo Lim et al.   FOOD AND CHEMICAL TOXICOLOGY

Alpha-Asarone, a Major Component ofAcorus gramineus, Attenuates Corticosterone-Induced Anxiety-Like Behaviours via Modulating TrkB Signaling Process

(2014) Bombi Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway

(2014) Sheng Zhang et al.   MOLECULAR NEUROBIOLOGY

β-Asarone Reverses Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior and Promotes Hippocampal Neurogenesis in Rats

(2014) Haiying Dong et al.   MOLECULES

Acorus calamus(The Healing Plant): a review on its medicinal potential, micropropagation and conservation

(2014) Vikas Sharma et al.   NATURAL PRODUCT RESEARCH

Pathophysiology and Biomarkers in Acute Ischemic Stroke – A Review

(2014) Y Guo et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats

(2013) Yuan-Xiao Yang et al.   BMC Complementary and Alternative Medicine

Heat Shock Protein 70 Reduces α-Synuclein-Induced Predegenerative Neuronal Dystrophy in the α-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease

(2013) Teresa C. Moloney et al.   CNS Neuroscience & Therapeutics

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Natural Compounds May Open New Routes to Treatment of Amyloid Diseases

(2013) Jan Bieschke   Neurotherapeutics

Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome ofAcorus tatarinowii

(2013) Ping Han et al.   PHARMACEUTICAL BIOLOGY

β-Asarone induces senescence in colorectal cancer cells by inducing lamin B1 expression

(2013) Linna Liu et al.   PHYTOMEDICINE

An overview on traditional uses and pharmacological profile of Acorus calamus Linn. (Sweet flag) and other Acorus species

(2013) Sandeep B. Rajput et al.   PHYTOMEDICINE

Disruption of Protein Quality Control in Parkinson's Disease

(2013) C. Cook et al.   Cold Spring Harbor Perspectives in Medicine

Simultaneous Determination of Volatile Constituents fromAcorus tatarinowiiSchott in Rat Plasma by Gas Chromatography-Mass Spectrometry with Selective Ion Monitoring and Application in Pharmacokinetic Study

(2013) Xue Meng et al.   Journal of Analytical Methods in Chemistry

Brain Inflammation and Microglia: Facts and Misconceptions

(2013) Hey-Kyeong Jeong et al.   Experimental Neurobiology

Anticonvulsant Activity of Acute and Chronic Treatment with a-Asarone from Acorus gramineus in Seizure Models

(2012) Qi-Xiong Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cognitive Enhancing Effects of Alpha Asarone in Amnesic Mice by Influencing Cholinergic and Antioxidant Defense Mechanisms

(2012) Hemant KUMAR et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Epilepsy across the spectrum: Promoting health and understanding.

(2012) Mary Jane England et al.   EPILEPSY & BEHAVIOR

Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury

(2012) Silvia Manzanero et al.   NEUROCHEMISTRY INTERNATIONAL

Microglia in the developing brain: A potential target with lifetime effects

(2012) G. Jean Harry et al.   NEUROTOXICOLOGY

Anxiolytic-like Effect of α-Asarone in Mice

(2012) Shuang Liu et al.   PHYTOTHERAPY RESEARCH

Blood-Based Gene Expression Profiles Models for Classification of Subsyndromal Symptomatic Depression and Major Depressive Disorder

(2012) Zhenghui Yi et al.   PLoS One

Modulation of Neuronal Survival Factor MEF2 by Kinases in Parkinson’s Disease

(2012) Yue Yin et al.   Frontiers in Physiology

Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects

(2011) Arunachalam Muthuraman et al.   BMC Complementary and Alternative Medicine

Cytoprotective effects of growth factors: BDNF more potent than GDNF in an organotypic culture model of Parkinson's disease

(2011) K. Stahl et al.   BRAIN RESEARCH

Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients

(2011) Hua She et al.   JOURNAL OF CLINICAL INVESTIGATION

ER stress response plays an important role in aggregation of α-synuclein

(2011) Peizhou Jiang et al.   Molecular Neurodegeneration

Radioprotection by α-asarone: Prevention of genotoxicity and hematopoietic injury in mammalian organism

(2011) Divyasree Sandeep et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Beta-Asarone Improves Cognitive Function by Suppressing Neuronal Apoptosis in the Beta-Amyloid Hippocampus Injection Rats

(2010) Yutao Geng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins

(2010) Chengchong Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of wound-healing activity of Acorus calamus Linn.

(2010) Nilesh Jain et al.   NATURAL PRODUCT RESEARCH

A negative regulator of MAP kinase causes depressive behavior

(2010) Vanja Duric et al.   NATURE MEDICINE

Activities of α-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties

(2010) Nicole Pages et al.   NEUROSCIENCE RESEARCH

The ubiquitin proteasome system in neuropathology

(2009) Norman L. Lehman   ACTA NEUROPATHOLOGICA

Cell death: protein misfolding and neurodegenerative diseases

(2009) Tomohiro Nakamura et al.   APOPTOSIS

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

(2008) Adrienne M. Gorman   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Anti-inflammatory activity of a water extract of Acorus calamus L. leaves on keratinocyte HaCaT cells

(2008) Hyeri Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY