Metabolic Dysfunction and Oxidative Stress in Epilepsy

Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy

(2017) Alexei P. Kudin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy—Mitochondria, Calcium Dynamics and Reactive Oxygen Species

(2017) Stjepana Kovac et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway

(2017) Aleksandra Wojtala et al.   MITOCHONDRION

Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis

(2017) Jennifer N. Pearson et al.   NEUROBIOLOGY OF DISEASE

NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy

(2015) A. Pecorelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration

(2015) Eliska Holzerova et al.   BRAIN

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Hippocampal antioxidative system in mesial temporal lobe epilepsy

(2015) Aleksandar J. Ristić et al.   EPILEPSIA

Long-term safety and efficacy of stiripentol for the treatment of Dravet syndrome: A multicenter, open-label study in Japan

(2015) Yushi Inoue et al.   EPILEPSY RESEARCH

Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy

(2015) Jennifer N. Pearson et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial respiratory chain defects in skin fibroblasts from patients with Dravet syndrome

(2015) Stefano Doccini et al.   NEUROLOGICAL SCIENCES

Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy

(2015) Sreekanth Puttachary et al.   Biomed Research International

Oxidative Stress in Traumatic Brain Injury

(2014) Ana Rodriguez-Rodriguez et al.   CURRENT MEDICINAL CHEMISTRY

Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

(2014) S Kovac et al.   Cell Death & Disease

Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death

(2013) Jin Hee Kim et al.   BRAIN RESEARCH

Stiripentol in Dravet syndrome: Results of a retrospective U.S. study

(2013) Elaine C. Wirrell et al.   EPILEPSIA

Oxidative stress markers in the neocortex of drug-resistant epilepsy patients submitted to epilepsy surgery

(2013) Jordi Rumià et al.   EPILEPSY RESEARCH

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

Contribution of apoptosis-associated signaling pathways to epileptogenesis: lessons from Bcl-2 family knockouts

(2013) David C. Henshall et al.   Frontiers in Cellular Neuroscience

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

(2013) Scott C. Baraban et al.   Nature Communications

Deficiency of selenium and zinc as a causative factor for idiopathic intractable epilepsy

(2012) Mehmet Seven et al.   EPILEPSY RESEARCH

Post-Translational Oxidative Modification and Inactivation of Mitochondrial Complex I in Epileptogenesis

(2012) K. Ryan et al.   JOURNAL OF NEUROSCIENCE

Selenium induced anticonvulsant effect: A potential role of prostaglandin E1 receptor activation linked mechanism

(2012) Ashish K. Rehni et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Oxidative stress markers and phosphorus magnetic resonance spectroscopy in a patient with GLUT1 deficiency treated with modified Atkins diet

(2011) Yuri Kitamura et al.   BRAIN & DEVELOPMENT

The ketogenic diet for Dravet syndrome and other epileptic encephalopathies: An Italian consensus

(2011) Pierangelo Veggiotti et al.   EPILEPSIA

Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury

(2011) Ayako Furukawa et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin

(2011) Li-Ping Liang et al.   NEUROBIOLOGY OF DISEASE

Respiration-dependent H2O2Removal in Brain Mitochondria via the Thioredoxin/Peroxiredoxin System

(2010) Derek A. Drechsel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial DNA Mutation-Elicited Oxidative Stress, Oxidative Damage, and Altered Gene Expression in Cultured Cells of Patients with MERRF Syndrome

(2010) Shi-Bei Wu et al.   MOLECULAR NEUROBIOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactive oxygen species generated by NADPH oxidase are involved in neurodegeneration in the pilocarpine model of temporal lobe epilepsy

(2010) Rafaela R.F. Pestana et al.   NEUROSCIENCE LETTERS

Correlation Between Serum Selenium Level and Febrile Seizures

(2010) Abolfazl Mahyar et al.   PEDIATRIC NEUROLOGY

Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome

(2010) A. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in the Expression of Selenoproteins in Mesial Temporal Lobe Epilepsy Patients

(2009) Ayşe Yüzbaşioğlu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Mitochondria, oxidative stress, and temporal lobe epilepsy

(2009) Simon Waldbaum et al.   EPILEPSY RESEARCH

Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke

(2009) C. L. Allen et al.   International Journal of Stroke

Mitochondrial membrane permeabilization in neuronal injury

(2009) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid

(2009) Jaroslava Folbergrová et al.   NEUROCHEMISTRY INTERNATIONAL

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H2O2-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures

(2009) David Cantu et al.   PLoS One

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Spectrum of SCN1A gene mutations associated with Dravet syndrome: analysis of 333 patients

(2008) C Depienne et al.   JOURNAL OF MEDICAL GENETICS

Selenium and Topiramate Modulates Brain Microsomal Oxidative Stress Values, Ca2+-ATPase Activity, and EEG Records in Pentylentetrazol-Induced Seizures in Rats

(2008) Mustafa Nazıroğlu et al.   JOURNAL OF MEMBRANE BIOLOGY

Mitochondrial DNA damage and impaired base excision repair during epileptogenesis

(2008) Stuart G. Jarrett et al.   NEUROBIOLOGY OF DISEASE

Modulators of neuronal cell death in epilepsy

(2007) D HENSHALL et al.   CURRENT OPINION IN PHARMACOLOGY

Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats

(2007) Eun-Joo Shin et al.   NEUROCHEMISTRY INTERNATIONAL

Enhanced hippocampal F2-isoprostane formation following kainate-induced seizures

(2003) Manisha Patel et al.   JOURNAL OF NEUROCHEMISTRY