Journal
BIOMOLECULES
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/biom11050718
Keywords
Alpha-Synuclein; mitochondria; VDAC; Parkinson's disease; mitochondrial dysfunction
Categories
Funding
- AIM Linea 1 Salute [AIM1833071]
- PIACERI [VDAC]
- Proof of Concept [PEPSLA POC 01_00054]
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The function of alpha-Synuclein, its interaction with VDAC, and its involvement in pathological processes are the main focus of current research on mitochondrial function modulation.
Alpha-Synuclein (alpha Syn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions. Mitochondrial porins or Voltage-Dependent Anion Channel (VDAC) proteins are the main gates for ADP/ATP and various substrates towards the organelle. Furthermore, they act as a mitochondrial hub for many cytosolic proteins, including alpha Syn. This review analyzes the main aspects of alpha Syn-mitochondria interaction, focusing on the role of VDAC and its emerging involvement in the pathological processes.
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