Effects of Metformin in Heart Failure: From Pathophysiological Rationale to Clinical Evidence
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Title
Effects of Metformin in Heart Failure: From Pathophysiological Rationale to Clinical Evidence
Authors
Keywords
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Journal
Biomolecules
Volume 11, Issue 12, Pages 1834
Publisher
MDPI AG
Online
2021-12-06
DOI
10.3390/biom11121834
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Note: Only part of the references are listed.- Metformin: A Novel Weapon Against Inflammation
- (2021) Bo Bai et al. Frontiers in Pharmacology
- The Association Between Metformin Treatment and Outcomes in Type 2 Diabetes Mellitus Patients With Heart Failure With Preserved Ejection Fraction: A Retrospective Study
- (2021) Jianfang Wang et al. Frontiers in Cardiovascular Medicine
- Hospitalization for Heart Failure Among Patients With Diabetes Mellitus and Reduced Kidney Function Treated With Metformin Versus Sulfonylureas: A Retrospective Cohort Study
- (2021) Tadarro L. Richardson et al. Journal of the American Heart Association
- Efficacy and durability of multifactorial intervention on mortality and MACEs: a randomized clinical trial in type-2 diabetic kidney disease
- (2021) Ferdinando Carlo Sasso et al. Cardiovascular Diabetology
- Comparative effectiveness and safety of sodium‐glucose cotransporter‐2 inhibitors versus metformin in patients with type 2 diabetes: An observational study using data from routine care
- (2021) Michael Fralick et al. DIABETES OBESITY & METABOLISM
- GLP-1 receptor agonists for cardiovascular outcomes with and without metformin. A systematic review and meta-analysis of cardiovascular outcomes trials
- (2021) Apostolos Tsapas et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Does a strict glycemic control during acute coronary syndrome play a cardioprotective effect? Pathophysiology and clinical evidence
- (2021) Alfredo Caturano et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Metformin Affects Cardiac Arachidonic Acid Metabolism and Cardiac Lipid Metabolite Storage in a Prediabetic Rat Model
- (2021) Denisa Miklankova et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo
- (2021) Zhenyu Jiao et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Risk of Death and Heart Failure among Patients with Type 2 Diabetes Treated by Metformin and Nonmetformin Monotherapy: A Real-World Study
- (2021) Siyao He et al. Journal of Diabetes Research
- Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure
- (2021) Huihui Li et al. Frontiers in Physiology
- The Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms
- (2021) Teresa Salvatore et al. Frontiers in Medicine
- Metformin suppresses phenylephrine-induced hypertrophic responses by inhibiting p300-HAT activity in cardiomyocytes
- (2021) Yoichi Sunagawa et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Does Metformin Interfere With the Cardiovascular Benefits of SGLT2 Inhibitors? Questions About Its Role as the Cornerstone of Diabetes Treatment
- (2020) Milton Packer AMERICAN JOURNAL OF MEDICINE
- The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity
- (2020) Kerstin N. Timm et al. CARDIOVASCULAR DRUGS AND THERAPY
- Metformin: An old drug against old age and associated morbidities
- (2020) Teresa Salvatore et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Association of glucose-lowering medications with cardiovascular outcomes: an umbrella review and evidence map
- (2020) Jianhong Zhu et al. Lancet Diabetes & Endocrinology
- Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis
- (2020) Pan Luo et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy
- (2020) Zongna Ren et al. CIRCULATION
- Longevity genes, cardiac ageing, and the pathogenesis of cardiomyopathy: implications for understanding the effects of current and future treatments for heart failure
- (2020) Milton Packer EUROPEAN HEART JOURNAL
- Metformin and heart failure–related outcomes in patients with or without diabetes: a systematic review of randomized controlled trials
- (2020) Phiwayinkosi V. Dludla et al. HEART FAILURE REVIEWS
- Metformin regulates adiponectin signalling in epicardial adipose tissue and reduces atrial fibrillation vulnerability
- (2020) Biao Li et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages
- (2020) Qin Fei et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Lipid Accumulation in Hearts Transplanted From Nondiabetic Donors to Diabetic Recipients
- (2020) Raffaele Marfella et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The impact of metformin and aspirin on T-cell mediated inflammation: A systematic review of in vitro and in vivo findings
- (2020) Tawanda Maurice Nyambuya et al. LIFE SCIENCES
- Metformin treatment in heart failure with preserved ejection fraction: a systematic review and meta-regression analysis
- (2020) Amera Halabi et al. Cardiovascular Diabetology
- Contemporary Treatment Patterns and Clinical Outcomes of Comorbid Diabetes Mellitus and HFrEF
- (2020) Muthiah Vaduganathan et al. JACC-Heart Failure
- The DANish randomized, double-blind, placebo controlled trial in patients with chronic HEART failure (DANHEART): A 2 x 2 factorial trial of hydralazine-isosorbide dinitrate in patients with chronic heart failure (H-HeFT) and metformin in patients with chronic heart failure and diabetes or prediabetes (met-HeFT)
- (2020) Henrik Wiggers et al. AMERICAN HEART JOURNAL
- Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes
- (2020) Xu Cheng et al. Cell Metabolism
- SGLT2 inhibitors with and without metformin: a meta‐analysis of cardiovascular, kidney and mortality outcomes
- (2020) Brendon L Neuen et al. DIABETES OBESITY & METABOLISM
- Mortality risk with preadmission metformin use in patients with COVID‐19 and diabetes: A meta‐analysis
- (2020) Chia Siang Kow et al. JOURNAL OF MEDICAL VIROLOGY
- Metformin protects high glucose‑cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway
- (2020) Xiang‑Dong Liu et al. Molecular Medicine Reports
- Metformin: A Potential Therapeutic Tool for Rheumatologists
- (2020) Teresa Salvatore et al. Pharmaceuticals
- 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2021
- (2020) DIABETES CARE
- Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?
- (2020) Teresa Salvatore et al. Biomedicines
- Cardiovascular events and mortality among type 2 diabetes mellitus patients newly prescribed first-line blood glucose-lowering drugs monotherapies: A population-based cohort study in the Catalan electronic medical record database, SIDIAP, 2010-2015
- (2020) Raquel Herrera Comoglio et al. Primary Care Diabetes
- T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword
- (2019) Karin H. Simons et al. Nature Reviews Cardiology
- Astragaloside IV promotes the eNOS/NO/cGMP pathway and improves left ventricular diastolic function in rats with metabolic syndrome
- (2019) Xin Lin et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Metformin in patients with and without diabetes: a paradigm shift in cardiovascular disease management
- (2019) Fei Luo et al. Cardiovascular Diabetology
- Mechanisms of action of metformin with special reference to cardiovascular protection
- (2019) Alexey V. Zilov et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial
- (2019) Mohapradeep Mohan et al. EUROPEAN HEART JOURNAL
- Cardiac Calcitropes, Myotropes, and Mitotropes
- (2019) Mitchell A. Psotka et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Heart failure and the prognostic impact and incidence of new-onset of diabetes mellitus: a nationwide cohort study
- (2019) B. Zareini et al. Cardiovascular Diabetology
- Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis
- (2019) Yechen Han et al. Cardiovascular Diabetology
- Metformin monotherapy significantly decreases epicardial adipose tissue thickness in newly diagnosed type 2 diabetes patients
- (2019) Murat Ziyrek et al. Revista Portuguesa de Cardiologia
- Class effects of SGLT2 inhibitors on cardiorenal outcomes
- (2019) Aaron Y. Kluger et al. Cardiovascular Diabetology
- 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD
- (2019) Francesco Cosentino et al. EUROPEAN HEART JOURNAL
- Do Drugs That Ameliorate Epicardial Adipose Tissue Inflammation Have Concordant Benefits on Atrial Fibrillation and on Heart Failure with a Preserved Ejection Fraction?
- (2019) Milton Packer JOURNAL OF CARDIAC FAILURE
- Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis
- (2019) Julia Ritterhoff et al. CIRCULATION RESEARCH
- Metformin lactic acidosis: Should we still be afraid?
- (2019) Teresa Salvatore et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Association between long-term prescription of metformin and the progression of heart failure with preserved ejection fraction in patients with type 2 diabetes mellitus and hypertension
- (2019) Jun Gu et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Liver fibrosis by FibroScan ® independently of established cardiovascular risk parameters associates with macrovascular and microvascular complications in patients with type 2 diabetes
- (2019) Rosa Lombardi et al. LIVER INTERNATIONAL
- Metformin Use Is Associated With a Lower Risk of Hospitalization for Heart Failure in Patients With Type 2 Diabetes Mellitus: a Retrospective Cohort Analysis
- (2019) Chin‐Hsiao Tseng Journal of the American Heart Association
- Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials
- (2019) Søren L Kristensen et al. Lancet Diabetes & Endocrinology
- Are the cardiovascular and kidney benefits of empagliflozin influenced by baseline glucose‐lowering therapy?
- (2019) Silvio E. Inzucchi et al. DIABETES OBESITY & METABOLISM
- A randomised, double‐blind, placebo‐controlled trial of metformin on myocardial efficiency in insulin‐resistant chronic heart failure patients without diabetes
- (2019) Anders Hostrup Larsen et al. EUROPEAN JOURNAL OF HEART FAILURE
- Intracanal Metformin Promotes Healing of Apical Periodontitis via Suppressing Inducible Nitric Oxide Synthase Expression and Monocyte Recruitment
- (2019) Han-Wei Wang et al. JOURNAL OF ENDODONTICS
- Cardioprotection by Metformin: Beneficial Effects Beyond Glucose Reduction
- (2018) Leon Varjabedian et al. American Journal of Cardiovascular Drugs
- Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial
- (2018) Scott D. Solomon et al. Circulation-Heart Failure
- Acute vs Cumulative Benefits of Metformin use in Patients with Type 2 Diabetes and Heart Failure
- (2018) Daniala L. Weir et al. DIABETES OBESITY & METABOLISM
- Aldolase promotes the development of cardiac hypertrophy by targeting AMPK signaling
- (2018) Yapeng Li et al. EXPERIMENTAL CELL RESEARCH
- Metformin in non-diabetic hyperglycaemia: the GLINT feasibility RCT
- (2018) Simon J Griffin et al. HEALTH TECHNOLOGY ASSESSMENT
- Mechanisms of physiological and pathological cardiac hypertrophy
- (2018) Michinari Nakamura et al. Nature Reviews Cardiology
- Metabolic remodelling in heart failure
- (2018) Edoardo Bertero et al. Nature Reviews Cardiology
- MicroRNA Regulation of the Hyper-Proliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes Mellitus
- (2018) Daniele Torella et al. DIABETES
- Metabolic Effects of Metformin in the Failing Heart
- (2018) Aleksandra Dziubak et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
- (2018) Roger W. Hunter et al. NATURE MEDICINE
- AMPK: a therapeutic target of heart failure—not only metabolism regulation
- (2018) Xuan Li et al. BIOSCIENCE REPORTS
- Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance
- (2018) Rebecca E. Slater et al. JOURNAL OF GENERAL PHYSIOLOGY
- Role of Tight Glycemic Control during Acute Coronary Syndrome on CV Outcome in Type 2 Diabetes
- (2018) Ferdinando Carlo Sasso et al. Journal of Diabetes Research
- Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention
- (2017) Sebastian Brings et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metformin and risk of long-term mortality following an admission for acute heart failure
- (2017) Lorenzo Fácila et al. Journal of Cardiovascular Medicine
- Effects of metformin on blood pressure in nondiabetic patients
- (2017) Long Zhou et al. JOURNAL OF HYPERTENSION
- Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
- (2017) Bruce Neal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Metformin attenuates ER stress–induced mitochondrial dysfunction
- (2017) Qun Chen et al. Translational Research
- Comparative Safety of Sulfonylurea and Metformin Monotherapy on the Risk of Heart Failure: A Cohort Study
- (2017) Christianne L. Roumie et al. Journal of the American Heart Association
- Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial
- (2017) John R Petrie et al. Lancet Diabetes & Endocrinology
- Liver biopsy in type 2 diabetes mellitus: Steatohepatitis represents the sole feature of liver damage
- (2017) Mario Masarone et al. PLoS One
- Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice
- (2016) Vinodkumar B. Pillai et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Fuel availability and fate in cardiac metabolism: A tale of two substrates
- (2016) Florencia Pascual et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- SIRT3-AMPK Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)
- (2016) Yen-Chun Lai et al. CIRCULATION
- Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance
- (2016) Amy R. Cameron et al. CIRCULATION RESEARCH
- Assessing Cardiac Metabolism
- (2016) Heinrich Taegtmeyer et al. CIRCULATION RESEARCH
- Impact of Improved Glycemic Control on Cardiac Function in Type 2 Diabetes MellitusCLINICAL PERSPECTIVE
- (2016) Melissa Leung et al. Circulation-Cardiovascular Imaging
- Risk Related to Pre–Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection FractionCLINICAL PERSPECTIVE
- (2016) Søren L. Kristensen et al. Circulation-Heart Failure
- Initial Combination Therapy With Canagliflozin Plus Metformin Versus Each Component as Monotherapy for Drug-Naïve Type 2 Diabetes
- (2016) Julio Rosenstock et al. DIABETES CARE
- METFORMIN: NONGLYCEMIC EFFECTS AND POTENTIAL NOVEL INDICATIONS
- (2016) Abeer Anabtawi et al. Endocrine Practice
- In-hospital and 1-year mortality associated with diabetes in patients with acute heart failure: results from the ESC-HFA Heart Failure Long-Term Registry
- (2016) Giovanni Targher et al. EUROPEAN JOURNAL OF HEART FAILURE
- Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes
- (2016) Suetonia C. Palmer et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The Effect of Metformin on Diastolic Function in Patients Presenting with ST-Elevation Myocardial Infarction
- (2016) Lawien Al Ali et al. PLoS One
- The emerging role of Toll-like receptor 4 in myocardial inflammation
- (2016) Y Yang et al. Cell Death & Disease
- Metformin Protects H9C2 Cardiomyocytes from High-Glucose and Hypoxia/Reoxygenation Injury via Inhibition of Reactive Oxygen Species Generation and Inflammatory Responses: Role of AMPK and JNK
- (2016) Mingyan Hu et al. Journal of Diabetes Research
- Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade
- (2016) Fenqing Shang et al. PLoS One
- Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy
- (2015) Lifang Yang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Effect of metformin monotherapy on cardiovascular diseases and mortality: a retrospective cohort study on Chinese type 2 diabetes mellitus patients
- (2015) Colman Siu Cheung Fung et al. Cardiovascular Diabetology
- Impact of Diabetes Mellitus on Hospitalization for Heart Failure, Cardiovascular Events, and DeathCLINICAL PERSPECTIVE
- (2015) Matthew A. Cavender et al. CIRCULATION
- Is AMPK the savior of the failing heart?
- (2015) Ty T. Kim et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect
- (2015) Yoshifumi Saisho Endocrine Metabolic & Immune Disorders-Drug Targets
- Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction
- (2014) Hamid Soraya et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Metformin Protects Against Systolic Overload–Induced Heart Failure Independent of AMP-Activated Protein Kinase α2
- (2014) Xin Xu et al. HYPERTENSION
- Effect of Metformin on Left Ventricular Function After Acute Myocardial Infarction in Patients Without Diabetes
- (2014) Chris P. H. Lexis et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria
- (2014) Jessica Soto Hernández et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKα1
- (2014) Gauthier Noppe et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Metformin mitigates apoptosis in ischemic myocardium
- (2014) Nassrene Y. Elmadhun et al. JOURNAL OF SURGICAL RESEARCH
- AMPK activation: a therapeutic target for type 2 diabetes?
- (2014) Asish Saha et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- Cardiac Metabolism in Heart Failure
- (2013) Torsten Doenst et al. CIRCULATION RESEARCH
- Comparative Safety and Effectiveness of Metformin in Patients With Diabetes Mellitus and Heart Failure
- (2013) Dean T. Eurich et al. Circulation-Heart Failure
- Metformin revisited: A critical review of the benefit–risk balance in at-risk patients with type 2 diabetes
- (2013) A.J. Scheen et al. DIABETES & METABOLISM
- Metformin in lung cancer: rationale for a combination therapy
- (2013) Floriana Morgillo et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1)- and Estrogen-related Receptor (ERR)-induced Regulator in Muscle 1 (PERM1) Is a Tissue-specific Regulator of Oxidative Capacity in Skeletal Muscle Cells
- (2013) Yoshitake Cho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metformin Inhibits Angiotensin II-Induced Differentiation of Cardiac Fibroblasts into Myofibroblasts
- (2013) Jian Bai et al. PLoS One
- Glucose Regulation of Load‐Induced mTOR Signaling and ER Stress in Mammalian Heart
- (2013) Shiraj Sen et al. Journal of the American Heart Association
- Lipid Metabolism and Toxicity in the Heart
- (2012) Ira J. Goldberg et al. Cell Metabolism
- Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model
- (2012) A. Cittadini et al. DIABETES
- The effect of metformin on insulin resistance and exercise parameters in patients with heart failure
- (2012) Aaron K.F. Wong et al. EUROPEAN JOURNAL OF HEART FAILURE
- Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial
- (2012) Satyam Sarma et al. EUROPEAN JOURNAL OF HEART FAILURE
- Short-term treatment with metformin suppresses toll like receptors (TLRs) activity in isoproterenol-induced myocardial infarction in rat: Are AMPK and TLRs connected?
- (2012) Hamid Soraya et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes
- (2012) Hans-Henrik Parving et al. NEW ENGLAND JOURNAL OF MEDICINE
- Reappraisal of Metformin Efficacy in the Treatment of Type 2 Diabetes: A Meta-Analysis of Randomised Controlled Trials
- (2012) Rémy Boussageon et al. PLOS MEDICINE
- Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure
- (2011) Meimei Yin et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Oxidative stress and heart failure
- (2011) Hiroyuki Tsutsui et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
- (2011) Yu Li et al. Cell Metabolism
- Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats
- (2011) Jan Benes et al. CLINICAL SCIENCE
- Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice
- (2011) Z. Xie et al. DIABETES
- Predictors of early-stage left ventricular dysfunction in type 2 diabetes: results of DYDA study
- (2011) Carlo B Giorda et al. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
- Metformin therapy and prognosis of patients with heart failure and new-onset diabetes mellitus. A propensity-matched study in the community
- (2011) Sotero P. Romero et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Tight Glycemic Control May Increase Regenerative Potential of Myocardium during Acute Infarction
- (2011) Raffaele Marfella et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Effect of Metformin on Mortality in Patients With Heart Failure and Type 2 Diabetes Mellitus
- (2010) Josie M.M. Evans et al. AMERICAN JOURNAL OF CARDIOLOGY
- Metformin Use and Mortality Among Patients With Diabetes and AtherothrombosisMetformin Use With Diabetes and Atherothrombosis
- (2010) Ronan Roussel ARCHIVES OF INTERNAL MEDICINE
- Metformin attenuates cardiac fibrosis by inhibiting the TGFβ1–Smad3 signalling pathway
- (2010) Han Xiao et al. CARDIOVASCULAR RESEARCH
- AMP-activated protein kinase and its downstream transcriptional pathways
- (2010) Carles Cantó et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Metformin Use and Mortality in Ambulatory Patients With Diabetes and Heart Failure
- (2010) David Aguilar et al. Circulation-Heart Failure
- Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats
- (2010) Cheng-Xi Zhang et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Metformin improves cardiac function in rats via activation of AMP-activated protein kinase
- (2010) Xiao-Fang Wang et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Treatment of Type 2 Diabetes and Outcomes in Patients With Heart Failure: A Nested Case-Control Study From the U.K. General Practice Research Database
- (2010) M. R. MacDonald et al. DIABETES CARE
- Blood Pressure and Cardiovascular Disease Risk in the Veterans Affairs Diabetes Trial
- (2010) R. J. Anderson et al. DIABETES CARE
- Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials
- (2010) C. Lamanna et al. DIABETES OBESITY & METABOLISM
- Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study
- (2010) C. Andersson et al. DIABETOLOGIA
- Metformin is associated with improved left ventricular diastolic function measured by tissue Doppler imaging in patients with diabetes
- (2010) Charlotte Andersson et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Metformin Activates AMP Kinase through Inhibition of AMP Deaminase
- (2010) Jiangyong Ouyang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The risk of developing coronary artery disease or congestive heart failure, and overall mortality, in type 2 diabetic patients receiving rosiglitazone, pioglitazone, metformin, or sulfonylureas: a retrospective analysis
- (2009) Kevin M. Pantalone et al. ACTA DIABETOLOGICA
- Metformin Prevents Progression of Heart Failure in Dogs
- (2009) Hideyuki Sasaki et al. CIRCULATION
- Metformin Therapy and Outcomes in Patients With Advanced Systolic Heart Failure and Diabetes
- (2009) Digish D. Shah et al. JOURNAL OF CARDIAC FAILURE
- AMPKα2 counteracts the development of cardiac hypertrophy induced by isoproterenol
- (2008) Elham Zarrinpashneh et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure
- (2008) Susheel Gundewar et al. CIRCULATION RESEARCH
- Is the Combination of Sulfonylureas and Metformin Associated With an Increased Risk of Cardiovascular Disease or All-Cause Mortality?: A meta-analysis of observational studies
- (2008) A. D. Rao et al. DIABETES CARE
- Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure: An analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme
- (2008) M. R. MacDonald et al. EUROPEAN HEART JOURNAL
- The risk of heart failure in patients with type 2 diabetes treated with oral agent monotherapy
- (2008) Finlay A. McAlister et al. EUROPEAN JOURNAL OF HEART FAILURE
- Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- Effects of Intensive Glucose Lowering in Type 2 Diabetes
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- 10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
- (2008) Rury R. Holman et al. NEW ENGLAND JOURNAL OF MEDICINE
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