Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance

Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1Novelty and Significance

(2018) Anna-Eliane Hopf et al.   CIRCULATION RESEARCH

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

(2018) Martin Liss et al.   PLoS One

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

(2016) Navdeep S. Chandel et al.   Cell Metabolism

Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection FractionClinical Perspective

(2016) Mei Methawasin et al.   CIRCULATION

Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn)Novelty and Significance

(2016) Mathew Bull et al.   CIRCULATION RESEARCH

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

(2016) Florian Hinze et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Understanding heart failure with preserved ejection fraction: where are we today?

(2016) L. van Heerebeek et al.   Netherlands Heart Journal

Metformin Treatment Prevents Sedentariness Related Damages in Mice

(2016) Pamela Senesi et al.   Journal of Diabetes Research

Phosphorylating Titin’s Cardiac N2B Element by ERK2 or CaMKII δ Lowers the Single Molecule and Cardiac Muscle Force

(2015) John Perkin et al.   BIOPHYSICAL JOURNAL

Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin

(2015) M. R. Zile et al.   CIRCULATION

METformin in DIastolic Dysfunction of MEtabolic Syndrome (MET-DIME) Trial: Rationale and Study Design

(2014) Ricardo Ladeiras-Lopes et al.   CARDIOVASCULAR DRUGS AND THERAPY

Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole

(2014) Mei Methawasin et al.   CIRCULATION

Gigantic Business

(2014) Wolfgang A. Linke et al.   CIRCULATION RESEARCH

Use of Metformin in Diseases of Aging

(2014) John M. Miles et al.   Current Diabetes Reports

The pathophysiology of heart failure with preserved ejection fraction

(2014) Barry A. Borlaug   Nature Reviews Cardiology

Metformin Protects Cardiomyocyte from Doxorubicin Induced Cytotoxicity through an AMP-Activated Protein Kinase Dependent Signaling Pathway: An In Vitro Study

(2014) Laura C. Kobashigawa et al.   PLoS One

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

(2014) Henk L. Granzier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shortening of the Elastic Tandem Immunoglobulin Segment of Titin Leads to Diastolic Dysfunction

(2013) Charles S. Chung et al.   CIRCULATION

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction

(2013) Margaret M. Redfield et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cardiac Titin and Heart Disease

(2013) Martin M. LeWinter et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Tuning the molecular giant titin through phosphorylation: Role in health and disease

(2013) Carlos Hidalgo et al.   TRENDS IN CARDIOVASCULAR MEDICINE

PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) Trial

(2012) Margaret M. Redfield et al.   Circulation-Heart Failure

Mechanics on Myocardium Deficient in the N2B Region of Titin: The Cardiac-Unique Spring Element Improves Efficiency of the Cardiac Cycle

(2011) Joshua Nedrud et al.   BIOPHYSICAL JOURNAL

Hyperphosphorylation of Mouse Cardiac Titin Contributes to Transverse Aortic Constriction-Induced Diastolic Dysfunction

(2011) Bryan Hudson et al.   CIRCULATION RESEARCH

Metformin Use and Mortality Among Patients With Diabetes and AtherothrombosisMetformin Use With Diabetes and Atherothrombosis

(2010) Ronan Roussel   ARCHIVES OF INTERNAL MEDICINE

Mineralocorticoid Accelerates Transition to Heart Failure With Preserved Ejection Fraction Via “Nongenomic Effects”

(2010) Selma F. Mohammed et al.   CIRCULATION

Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study

(2010) C. Andersson et al.   DIABETOLOGIA

Decreased Cardiac Functional Reserve in Heart Failure With Preserved Systolic Function

(2010) Holly S. Norman et al.   JOURNAL OF CARDIAC FAILURE

The risk of developing coronary artery disease or congestive heart failure, and overall mortality, in type 2 diabetic patients receiving rosiglitazone, pioglitazone, metformin, or sulfonylureas: a retrospective analysis

(2009) Kevin M. Pantalone et al.   ACTA DIABETOLOGICA

Transcriptional and Posttranslational Modifications of Titin

(2009) Attila Borbély et al.   CIRCULATION RESEARCH

PKC Phosphorylation of Titin’s PEVK Element

(2009) Carlos Hidalgo et al.   CIRCULATION RESEARCH

Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium

(2009) Attila Borbély et al.   CIRCULATION RESEARCH

Irbesartan in Patients with Heart Failure and Preserved Ejection Fraction

(2008) Barry M. Massie et al.   NEW ENGLAND JOURNAL OF MEDICINE