Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention

Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans

(2016) Owen R. Kinsky et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation

(2016) Mingzhan Xue et al.   DIABETES

Methylglyoxal is associated with changes in kidney function among individuals with screen-detected Type 2 diabetes mellitus

(2016) T. M. Jensen et al.   DIABETIC MEDICINE

Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics

(2016) Naila Rabbani et al.   GLYCOCONJUGATE JOURNAL

Pathways of the Maillard reaction under physiological conditions

(2016) Christian Henning et al.   GLYCOCONJUGATE JOURNAL

The pecking order of skin Advanced Glycation Endproducts (AGEs) as long-term markers of glycemic damage and risk factors for micro- and subclinical macrovascular disease progression in Type 1 diabetes

(2016) Vincent M. Monnier et al.   GLYCOCONJUGATE JOURNAL

Mass spectrometric determination of early and advanced glycation in biology

(2016) Naila Rabbani et al.   GLYCOCONJUGATE JOURNAL

Targeting advanced glycation with pharmaceutical agents: where are we now?

(2016) Danielle J. Borg et al.   GLYCOCONJUGATE JOURNAL

Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells

(2016) Jakob Morgenstern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of reactive carbonyl compounds in icodextrin-based peritoneal dialysis fluids by combined UHPLC-DAD and -MS/MS detection

(2016) Sabrina Gensberger-Reigl et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Comprehensive Analysis of Maillard Protein Modifications in Human Lenses: Effect of Age and Cataract

(2015) Mareen Smuda et al.   BIOCHEMISTRY

Diabetes-induced alterations in tissue collagen and carboxymethyllysine in rat kidneys: Association with increased collagen-degrading proteinases and amelioration by Cu(II)-selective chelation

(2015) Sebastian Brings et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of serum methylglyoxal on diabetic peripheral and cardiovascular autonomic neuropathy: the ADDITION Denmark study

(2015) C. S. Hansen et al.   DIABETIC MEDICINE

Specific tandem mass spectrometric detection of AGE-modified arginine residues in peptides

(2015) Rico Schmidt et al.   JOURNAL OF MASS SPECTROMETRY

Concise total synthesis of glucosepane

(2015) C. Draghici et al.   SCIENCE

Increased DNA Dicarbonyl Glycation and Oxidation Markers in Patients with Type 2 Diabetes and Link to Diabetic Nephropathy

(2015) Sahar Waris et al.   Journal of Diabetes Research

Dicarbonyl proteome and genome damage in metabolic and vascular disease

(2014) Naila Rabbani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Skin Advanced Glycation End Products Glucosepane and Methylglyoxal Hydroimidazolone Are Independently Associated With Long-term Microvascular Complication Progression of Type 1 Diabetes

(2014) Saul Genuth et al.   DIABETES

Effect of Metformin on Methylglyoxal Metabolism in Patients with Type 2 Diabetes

(2014) Z. Kender et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Dietary Influence on Urinary Excretion of 3-Deoxyglucosone and Its Metabolite 3-Deoxyfructose

(2014) Julia Degen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Extending the Spectrum of α-Dicarbonyl Compounds in Vivo

(2014) Christian Henning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement of methylglyoxal by stable isotopic dilution analysis LC-MS/MS with corroborative prediction in physiological samples

(2014) Naila Rabbani et al.   Nature Protocols

Increased plasma levels of the methylglyoxal in patients with newly diagnosed type 2 diabetes 初诊2型糖尿病患者血浆甲基乙二醛水平升高

(2014) Xiang Kong et al.   Journal of Diabetes

Glyoxylate, a New Marker Metabolite of Type 2 Diabetes

(2014) Victoria J. Nikiforova et al.   Journal of Diabetes Research

Maillard Degradation Pathways of Vitamin C

(2013) Mareen Smuda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The glyoxalase pathway: the first hundred years… and beyond

(2013) Marta Sousa Silva et al.   BIOCHEMICAL JOURNAL

Detection of oxidized and glycated proteins in clinical samples using mass spectrometry — A user's perspective

(2013) Paul J. Thornalley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Plasma levels of advanced glycation endproducts are associated with type 1 diabetes and coronary artery calcification

(2013) Marcelle GA van Eupen et al.   Cardiovascular Diabetology

The Effect of an EDTA-based Chelation Regimen on Patients With Diabetes Mellitus and Prior Myocardial Infarction in the Trial to Assess Chelation Therapy (TACT)

(2013) E. Escolar et al.  

Quantification of glyoxal, methylglyoxal and 3-deoxyglucosone in blood and plasma by ultra performance liquid chromatography tandem mass spectrometry: evaluation of blood specimen

(2013) Jean L.J.M. Scheijen et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice

(2013) F. Giacco et al.   DIABETES

Small- and Large-Fiber Neuropathy After 40 Years of Type 1 Diabetes: Associations with glycemic control and advanced protein glycation: the Oslo Study

(2013) K. A. Sveen et al.   DIABETES CARE

Early Progression of Diabetic Nephropathy Correlates With Methylglyoxal-Derived Advanced Glycation End Products

(2013) P. J. Beisswenger et al.   DIABETES CARE

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes

(2013) Olaf Brouwers et al.   DIABETOLOGIA

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

(2013) M. G. A. van Eupen et al.   DIABETOLOGIA

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation

(2013) G. Vistoli et al.   FREE RADICAL RESEARCH

Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction

(2013) Gervasio A. Lamas et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolic Transit of Dietary Methylglyoxal

(2013) Julia Degen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications

(2012) R. Nagai et al.   DIABETES

Where does plasma methylglyoxal originate from?

(2012) Miklós Péter Kalapos   DIABETES RESEARCH AND CLINICAL PRACTICE

Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?

(2012) T. Fleming et al.   DIABETOLOGIA

Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2012) S. E. Inzucchi et al.   DIABETOLOGIA

Cathepsins D and L reduce the toxicity of advanced glycation end products

(2012) Stefanie Grimm et al.   FREE RADICAL BIOLOGY AND MEDICINE

Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

(2012) Florian W Kiefer et al.   NATURE MEDICINE

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1

(2012) W. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unique Reactivity of N-Phenacyl-Derived Thiazolium Salts Toward α-Dicarbonyl Compounds

(2012) Taehan Kim et al.   REJUVENATION RESEARCH

Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics)

(2011) Tomoaki Uchiki et al.   AGING CELL

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

(2011) Mingzhan Xue et al.   BIOCHEMICAL JOURNAL

Higher Plasma Levels of Advanced Glycation End Products Are Associated With Incident Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes: A 12-year follow-up study

(2011) J. W. Nin et al.   DIABETES CARE

Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes: Potential role of AGER1 and SIRT1

(2011) J. Uribarri et al.   DIABETES CARE

Pyridorin in Type 2 Diabetic Nephropathy

(2011) E. J. Lewis et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals

(2011) Michal Schnaider Beeri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Glyoxalase in diabetes, obesity and related disorders

(2011) Naila Rabbani et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats

(2010) Ryoji Nagai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose

(2010) Arti Dhar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy

(2010) Jianxin Lu et al.   CLINICAL BIOCHEMISTRY

Methylglyoxal Is a Predictor in Type 2 Diabetic Patients of Intima-Media Thickening and Elevation of Blood Pressure

(2010) Susumu Ogawa et al.   HYPERTENSION

Formation of Arginine Modifications in a Model System ofNα-tert-Butoxycarbonyl (Boc)-Arginine with Methylglyoxal

(2010) Antje Klöpfer et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

(2010) Paul J. Thornalley et al.   NUCLEIC ACIDS RESEARCH

Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats

(2009) Arti Dhar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protein and energy metabolism in type 1 diabetes

(2009) Sadie L. Hebert et al.   CLINICAL NUTRITION

Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes

(2009) Beatriz Duran-Jimenez et al.   DIABETES

Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue

(2009) S. P. Baba et al.   DIABETES

A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type 2 diabetic patients: a randomised placebo-controlled study

(2009) G. J. S. Cooper et al.   DIABETOLOGIA

A comparative study of the chemical reactivity of pyridoxamine, Ac-Phe-Lys and Ac-Cys with various glycating carbonyl compounds

(2008) Miquel Adrover et al.   AMINO ACIDS

Advanced Glycation End Products of DNA: Quantification ofN2-(1-Carboxyethyl)-2′-deoxyguanosine in Biological Samples by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

(2008) Timothy Synold et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Analysis and biological relevance of advanced glycation end-products of DNA in eukaryotic cells

(2008) Viola Breyer et al.   FEBS Journal

The Role of Zinc, Copper and Iron in the Pathogenesis of Diabetes and Diabetic Complications: Therapeutic Effects by Chelators

(2008) Yang Zheng et al.   HEMOGLOBIN