HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in Trauma

Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties

(2021) Yiting Tang et al.   IMMUNITY

The Effect and Regulatory Mechanism of High Mobility Group Box-1 Protein on Immune Cells in Inflammatory Diseases

(2021) Yun Ge et al.   Cells

High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders

(2021) Sarah Saxena et al.   Cells

Targeting Inflammation Driven by HMGB1

(2020) Huan Yang et al.   Frontiers in Immunology

Nuclear Alarmin Cytokines in Inflammation

(2020) Lili Jiang et al.   Journal of Immunology Research

High Mobility Group Box-1 and Blood–Brain Barrier Disruption

(2020) Masahiro Nishibori et al.   Cells

Early Complement and Fibrinolytic Activation in a Rat Model of Blast-Induced Multi-Organ Damage

(2019) Zhangsheng Yang et al.   MILITARY MEDICINE

The complement receptor C5aR2 promotes protein kinase R expression and contributes to NLRP3 inflammasome activation and HMGB1 release from macrophages

(2019) Songlin Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Location is the key to function: HMGB1 in sepsis and trauma‐induced inflammation

(2019) Meihong Deng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

High Mobility Group Box-1 (HMGB1): A potential target in therapeutics

(2019) Eyaldeva C. Vijayakumar et al.   CURRENT DRUG TARGETS

Heparinoid sevuparin inhibits Streptococcus-induced vascular leak through neutralizing neutrophil-derived proteins

(2019) Joel Rasmuson et al.   FASEB JOURNAL

Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses

(2019) Zhenxing Cheng et al.   CRITICAL CARE MEDICINE

Biphasic Release of the Alarmin High Mobility Group Box 1 Protein Early After Trauma Predicts Poor Clinical Outcome

(2019) William Ottestad et al.   CRITICAL CARE MEDICINE

HMGB1–C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis

(2019) Tianye Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Danger Signals in the Pathogenesis and Perpetuation of Critical Illness

(2018) Kevin C. Ma et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of Complement Properdin in Renal Ischemia-Reperfusion Injury

(2018) Zinah Zwaini et al.   CURRENT GENE THERAPY

Danger signals in trauma

(2018) Borna Relja et al.   European Journal of Trauma and Emergency Surgery

Extracellular HMGB1 as a therapeutic target in inflammatory diseases

(2018) Ulf Andersson et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Early low-anticoagulant desulfated heparin after traumatic brain injury

(2018) Katsuhiro Nagata et al.   Journal of Trauma and Acute Care Surgery

Innate immune responses to trauma

(2018) Markus Huber-Lang et al.   NATURE IMMUNOLOGY

Hemorrhagic Shock

(2018) Jeremy W. Cannon   NEW ENGLAND JOURNAL OF MEDICINE

Early low-anticoagulant desulfated heparin after traumatic brain injury

(2018) Katsuhiro Nagata et al.   Journal of Trauma and Acute Care Surgery

High-Mobility Group Box 1-Induced Complement Activation Causes Sterile Inflammation

(2018) Sook Young Kim et al.   Frontiers in Immunology

“Stop the Bleed”: A U.S. Military Installation’s Model for Implementation of a Rapid Hemorrhage Control Program

(2018) James Alan Chambers et al.   MILITARY MEDICINE

Complement inhibition ameliorates blast-induced acute lung injury in rats: Potential role of complement in intracellular HMGB1-mediated inflammation

(2018) Yansong Li et al.   PLoS One

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair

(2017) Marco E. Bianchi et al.   IMMUNOLOGICAL REVIEWS

High Mobility Group Box-1 (HMGb1): Current Wisdom and Advancement as a Potential Drug Target

(2017) Sonya VanPatten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessment of key plasma metabolites in combat casualties

(2017) Elizabeth R. Lusczek et al.   Journal of Trauma and Acute Care Surgery

Assessment of key plasma metabolites in combat casualties

(2017) Elizabeth R. Lusczek et al.   Journal of Trauma and Acute Care Surgery

An Integrated Clinico-transcriptomic Approach Identifies a Central Role of the Heme Degradation Pathway for Septic Complications after Trauma

(2016) Daniel Rittirsch et al.   ANNALS OF SURGERY

Advances in the understanding of trauma-induced coagulopathy

(2016) R. Chang et al.   BLOOD

The Role of Extracellular Adenosine Triphosphate in Ischemic Organ Injury

(2016) Hailin Zhao et al.   CRITICAL CARE MEDICINE

A novel “complement-metabolism-inflammasome axis” as a key regulator of immune cell effector function

(2016) Giuseppina Arbore et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

C1 Inhibitor Limits Organ Injury and Prolongs Survival in Swine Subjected to Battlefield Simulated Injury

(2016) James C. Campbell et al.   SHOCK

2-O, 3-O-Desulfated Heparin Inhibits Neutrophil Elastase–Induced HMGB-1 Secretion and Airway Inflammation

(2014) Kathryn L. Griffin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The systemic immune response to trauma: an overview of pathophysiology and treatment

(2014) Janet M Lord et al.   LANCET

High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4

(2013) Melissa D. Laird et al.   GLIA

Partially-desulfated heparin improves survival inPseudomonaspneumonia by enhancing bacterial clearance and ameliorating lung injury

(2013) Lokesh Sharma et al.   Journal of Immunotoxicology

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

(2013) Xiaoling Qiang et al.   NATURE MEDICINE

An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies

(2013) Domenica Musumeci et al.   PHARMACOLOGY & THERAPEUTICS

Protective effects of decay-accelerating factor on blast-induced neurotrauma in rats

(2013) Yansong Li et al.   Acta Neuropathologica Communications

Agressions cérébrales, immunité et infections

(2012) A. Roquilly et al.   ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION

Anti-high mobility group box-1 antibody therapy for traumatic brain injury

(2012) Yu Okuma et al.   ANNALS OF NEUROLOGY

Biochemical regulation of the inflammasome

(2012) Jennifer K. Dowling et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Decay-accelerating factor limits hemorrhage-instigated tissue injury and improves resuscitation clinical parameters

(2012) Jurandir J. Dalle Lucca et al.   JOURNAL OF SURGICAL RESEARCH

HMGB1 and leukocyte migration during trauma and sterile inflammation

(2012) Emilie Venereau et al.   MOLECULAR IMMUNOLOGY

Early Complementopathy After Multiple Injuries in Humans

(2012) Anne-Maud Burk et al.   SHOCK

Effects of C1 Inhibitor on Tissue Damage in a Porcine Model of Controlled Hemorrhage

(2012) Jurandir J. Dalle Lucca et al.   SHOCK

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Decay-Accelerating Factor Mitigates Controlled Hemorrhage-Instigated Intestinal and Lung Tissue Damage and Hyperkalemia in Swine

(2011) Jurandir J. Dalle Lucca et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands

(2010) Narayanam V. Rao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

High-mobility group box 1 (HMGB1) as a master regulator of innate immunity

(2010) Alessandra Castiglioni et al.   CELL AND TISSUE RESEARCH

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATTENUATION OF PULMONARY INFLAMMATION AFTER EXPOSURE TO BLAST OVERPRESSURE BY N-ACETYLCYSTEINE AMIDE

(2009) Mikulas Chavko et al.   SHOCK

HMGB1 IS MARKEDLY ELEVATED WITHIN 6 HOURS OF MECHANICAL TRAUMA IN HUMANS

(2009) Erik D. Peltz et al.   SHOCK