The Role of Danger Signals in the Pathogenesis and Perpetuation of Critical Illness

S100A8/A9 and S100A9 reduce acute lung injury

(2017) Yuka Hiroshima et al.   IMMUNOLOGY AND CELL BIOLOGY

Mitochondrial DNA damage associated molecular patterns in ventilator-associated pneumonia

(2017) Jon D. Simmons et al.   Journal of Trauma and Acute Care Surgery

The role of extracellular histone in organ injury

(2017) Eleanor Silk et al.   Cell Death & Disease

Mitochondrial DNA damage associated molecular patterns in ventilator-associated pneumonia

(2017) Jon D. Simmons et al.   Journal of Trauma and Acute Care Surgery

Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine

(2016) Gabriel Moreno-Gonzalez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibiting High-Mobility Group Box 1 (HMGB1) Attenuates Inflammatory Cytokine Expression and Neurological Deficit in Ischemic Brain Injury Following Cardiac Arrest in Rats

(2016) Mei Xu et al.   INFLAMMATION

Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

(2016) Kim Timmermans et al.   INTENSIVE CARE MEDICINE

Association between S100B Levels and Long-Term Outcome after Aneurysmal Subarachnoid Hemorrhage: Systematic Review and Pooled Analysis

(2016) Pui Man Rosalind Lai et al.   PLoS One

DAMPs activating innate immune responses in sepsis

(2015) Jung-Woo Kang et al.   AGEING RESEARCH REVIEWS

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

(2015) Kiichi Nakahira et al.   ANTIOXIDANTS & REDOX SIGNALING

The Involvement of Danger-Associated Molecular Patterns in the Development of Immunoparalysis in Cardiac Arrest Patients

(2015) Kim Timmermans et al.   CRITICAL CARE MEDICINE

Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis*

(2015) Yasir Alhamdi et al.   CRITICAL CARE MEDICINE

Myeloid-related protein-14 deficiency promotes inflammation in staphylococcal pneumonia

(2015) Ahmed Achouiti et al.   EUROPEAN RESPIRATORY JOURNAL

N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP kinase signalling pathways

(2015) Jon Hazeldine et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study

(2015) Florian Uhle et al.   MEDIATORS OF INFLAMMATION

Mitochondrial Damage-Associated Molecular Patterns (MTDs) Are Released during Hepatic Ischemia Reperfusion and Induce Inflammatory Responses

(2015) Qianni Hu et al.   PLoS One

Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis

(2015) Safiah H. C. Mai et al.   SHOCK

Significance of Serum mtDNA Concentration in Lung Injury Induced by Hip Fracture

(2015) Li Gan et al.   SHOCK

Soluble RAGE and the RAGE Ligands HMGB1 and S100A12 in Critical Illness

(2015) Catherine Ingels et al.   SHOCK

Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

(2015) Kiyoshi Itagaki et al.   PLoS One

Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study

(2015) Matthieu Jabaudon et al.   PLoS One

Time-Dependent and Organ-Specific Changes in Mitochondrial Function, Mitochondrial DNA Integrity, Oxidative Stress and Mononuclear Cell Infiltration in a Mouse Model of Burn Injury

(2015) Bartosz Szczesny et al.   PLoS One

Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue

(2014) JIAN-ZHENG ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

High plasma levels of high mobility group box 1 is associated with the risk of sepsis in severe blunt chest trauma patients: a prospective cohort study

(2014) Xiao-Wen Wang et al.   Journal of Cardiothoracic Surgery

Plasma HSPA12B Is a Potential Predictor for Poor Outcome in Severe Sepsis

(2014) Ran Zhang et al.   PLoS One

Combining NSE and S100B with clinical examination findings to predict survival after resuscitation from cardiac arrest

(2014) Luis M. Calderon et al.   RESUSCITATION

Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia

(2014) Ahmed Achouiti et al.   THORAX

Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions

(2014) Judith Austermann et al.   Cell Reports

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

Defensins and Sepsis

(2014) Guo-Hao Xie et al.   Biomed Research International

Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials

(2014) Carolyn S Calfee et al.   Lancet Respiratory Medicine

Proinflammatory S100A12 Can Activate Human Monocytes via Toll-like Receptor 4

(2013) Dirk Foell et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: Time course and the association with clinical status

(2013) Satoshi Yamanouchi et al.   JOURNAL OF CRITICAL CARE

Toll-Like Receptor 4 Mediates Acute Lung Injury Induced by High Mobility Group Box-1

(2013) Yuxiao Deng et al.   PLoS One

The Plasma Mitochondrial DNA Is an Independent Predictor for Post-Traumatic Systemic Inflammatory Response Syndrome

(2013) Xiaoling Gu et al.   PLoS One

Prognostic value of cell-free DNA in plasma of out-of-hospital cardiac arrest survivors at ICU admission and 24h post-admission

(2013) Ivan Gornik et al.   RESUSCITATION

S100A12 and Soluble Receptor for Advanced Glycation End Products Levels During Human Severe Sepsis

(2013) Ahmed Achouiti et al.   SHOCK

High-Mobility Group Box 1 Mediates Persistent Splenocyte Priming in Sepsis Survivors

(2013) Sergio I. Valdés-Ferrer et al.   SHOCK

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Damage- and Pathogen-Associated Molecular Patterns and Alarmins: Keys to Sepsis?

(2012) S. Denk et al.   EUROPEAN SURGICAL RESEARCH

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

(2012) Pedro E. Marques et al.   HEPATOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Inducible Heat Shock Protein 70 Reduces T Cell Responses and Stimulatory Capacity of Monocyte-derived Dendritic Cells

(2012) Pawel Stocki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S100b as a Prognostic Biomarker in Outcome Prediction for Patients with Severe Traumatic Brain Injury

(2012) Akash Goyal et al.   JOURNAL OF NEUROTRAUMA

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plasma nuclear and mitochondrial DNA levels as predictors of outcome in severe sepsis patients in the emergency room

(2012) Chia-Te Kung et al.   Journal of Translational Medicine

Danger Signals Activating the Immune Response after Trauma

(2012) Stefanie Hirsiger et al.   MEDIATORS OF INFLAMMATION

Cathelicidins: family of antimicrobial peptides. A review

(2012) Ewa M. Kościuczuk et al.   MOLECULAR BIOLOGY REPORTS

HSP70 Enhances Immunosuppressive Function of CD4+CD25+FoxP3+ T Regulatory Cells and Cytotoxicity in CD4+CD25− T Cells

(2012) Julian Wachstein et al.   PLoS One

Circulating cell-free mitochondrial DNA: A better early prognostic marker in patients with out-of-hospital cardiac arrest

(2012) F. Arnalich et al.   RESUSCITATION

Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims: A pilot study

(2012) Yasutaka Oda et al.   RESUSCITATION

Systemic release of cytokines and heat shock proteins in porcine models of polytrauma and hemorrhage*

(2011) Todd A. Baker et al.   CRITICAL CARE MEDICINE

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice

(2011) Hai Huang et al.   HEPATOLOGY

The Role of Heat Shock Protein 70 in Mediating Age-Dependent Mortality in Sepsis

(2011) K. W. McConnell et al.   JOURNAL OF IMMUNOLOGY

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Apoptotic cell-free DNA promotes inflammation in haemodialysis patients

(2011) J. Atamaniuk et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A Monoclonal Antibody Against RAGE Alters Gene Expression and is Protective in Experimental Models of Sepsis and Pneumococcal Pneumonia

(2011) Eirini Christaki et al.   SHOCK

CD91-dependent programming of T-helper cell responses following heat shock protein immunization

(2011) Sudesh Pawaria et al.   Nature Communications

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Mechanical ventilation modulates Toll-like receptor signaling pathway in a sepsis-induced lung injury model

(2010) Jesús Villar et al.   INTENSIVE CARE MEDICINE

Uric acid promotes an acute inflammatory response to sterile cell death in mice

(2010) Hajime Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

BURN TRAUMA INDUCES EARLY HMGB1 RELEASE IN PATIENTS

(2010) János Lantos et al.   SHOCK

Hyaluronic acid predicts hepatic fibrosis in children with nonalcoholic fatty liver disease

(2010) Valerio Nobili et al.   Translational Research

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

The Receptor for Advanced Glycation End Products Impairs Host Defense in Pneumococcal Pneumonia

(2009) M. A. D. van Zoelen et al.   JOURNAL OF IMMUNOLOGY

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Serum S-100B is superior to neuron-specific enolase as an early prognostic biomarker for neurological outcome following cardiopulmonary resuscitation

(2009) Koichiro Shinozaki et al.   RESUSCITATION

THE EFFECT OF HIGH-MOBILITY GROUP BOX 1 PROTEIN ON ACTIVITY OF REGULATORY T CELLS AFTER THERMAL INJURY IN RATS

(2009) Li-feng Huang et al.   SHOCK

HMGB1 IS MARKEDLY ELEVATED WITHIN 6 HOURS OF MECHANICAL TRAUMA IN HUMANS

(2009) Erik D. Peltz et al.   SHOCK

Cell-Free Plasma DNA as a Predictor of Outcome in Severe Sepsis and Septic Shock

(2008) K. Saukkonen et al.   CLINICAL CHEMISTRY

Pattern recognition receptors and control of adaptive immunity

(2008) Noah W. Palm et al.   IMMUNOLOGICAL REVIEWS

Gene profiling in human blood leucocytes during recovery from septic shock

(2008) Didier Payen et al.   INTENSIVE CARE MEDICINE

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases

(2008) Eva Lorenz et al.   RESPIRATORY MEDICINE