Danger signals in trauma

Innate immune responses to trauma

(2018) Markus Huber-Lang et al.   NATURE IMMUNOLOGY

Using IL-6 concentrations in the first 24 h following trauma to predict immunological complications and mortality in trauma patients: a meta-analysis

(2017) Zhi Qiao et al.   European Journal of Trauma and Emergency Surgery

Update on the role of endothelial cells in trauma

(2017) J. Greven et al.   European Journal of Trauma and Emergency Surgery

Interleukin-17 as a predictor of sepsis in polytrauma patients: a prospective cohort study

(2017) M. Ahmed Ali et al.   European Journal of Trauma and Emergency Surgery

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular nucleic acids in immunity and cardiovascular responses: between alert and disease

(2017) Heiko Herwald et al.   THROMBOSIS AND HAEMOSTASIS

Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-α and c-Jun N-terminal kinase pathway

(2017) Bin-Fei Zhang et al.   Journal of Orthopaedic Surgery and Research

Gout: An old disease in new perspective – A review

(2017) Gaafar Ragab et al.   Journal of Advanced Research

Circulating Extracellular Histones Are Clinically Relevant Mediators of Multiple Organ Injury

(2016) Chihiro Kawai et al.   AMERICAN JOURNAL OF PATHOLOGY

The danger zone: Systematic review of the role of HMGB1 danger signalling in traumatic brain injury

(2016) Taylor M. Parker et al.   BRAIN INJURY

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

Serum levels of HSP70 and other DAMP proteins can aid in patient diagnosis after traumatic injury

(2016) Biqiong Ren et al.   CELL STRESS & CHAPERONES

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

Post-translational regulation of inflammasomes

(2016) Jie Yang et al.   Cellular & Molecular Immunology

Diagnostic and Predictive Levels of Calcium-binding Protein A8 and Tumor Necrosis Factor Receptor-associated Factor 6 in Sepsis-associated Encephalopathy: A Prospective Observational Study

(2016) Yu-Hang Ai et al.   CHINESE MEDICAL JOURNAL

Early CSF and Serum S100B Concentrations for Outcome Prediction in Traumatic Brain Injury and Subarachnoid Hemorrhage

(2016) Isabel Kellermann et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Key Role of DAMP in Inflammation, Cancer, and Tissue Repair

(2016) Franco Pandolfi et al.   CLINICAL THERAPEUTICS

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

sTREM-1, sIL-2Rα, and IL-6, but not sCD163, might predict sepsis in polytrauma patients: a prospective cohort study

(2016) S. Trancă et al.   European Journal of Trauma and Emergency Surgery

IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease

(2016) Hao Zhou et al.   HEPATOLOGY

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

Role of cellular events in the pathophysiology of sepsis

(2016) Chandra Bhan et al.   INFLAMMATION RESEARCH

Red cell DAMPs and inflammation

(2016) Rafaela Mendonça et al.   INFLAMMATION RESEARCH

S100A8/A9: From basic science to clinical application

(2016) Monika Pruenster et al.   PHARMACOLOGY & THERAPEUTICS

S-100 B Concentrations Are a Predictor of Decreased Survival in Patients with Major Trauma, Independently of Head Injury

(2016) Carmen Andrea Pfortmueller et al.   PLoS One

Danger in the Intensive Care Unit

(2016) Kim Timmermans et al.   SHOCK

Innate danger signals in acute injury: From bench to bedside

(2016) Mathieu Fontaine et al.   Anaesthesia Critical Care & Pain Medicine

S100A12 and the S100/CalgranulinsSignificance

(2015) Adam Oesterle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

(2015) Yuriy Pomeshchik et al.   BRAIN BEHAVIOR AND IMMUNITY

Elevated serum uric acid after injury correlates with the early acute kidney in severe burns

(2015) Juan Liang et al.   BURNS

C-type lectins in immunity: recent developments

(2015) Ivy M Dambuza et al.   CURRENT OPINION IN IMMUNOLOGY

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14

(2015) J. J. Fong et al.   EMBO JOURNAL

Sepsis in fatal pelvic trauma patients: report from a level-1 Indian Trauma Centre

(2015) S. Lalwani et al.   European Journal of Trauma and Emergency Surgery

Risk factors for sepsis in Korean trauma patients

(2015) J.-H. Park et al.   European Journal of Trauma and Emergency Surgery

Assessing bicycle-related trauma using the biomarker S100B reveals a correlation with total injury severity

(2015) E. P. Thelin et al.   European Journal of Trauma and Emergency Surgery

Impact of haemorrhagic shock intensity on the dynamic of alarmins release in porcine poly-trauma animal model

(2015) K. Horst et al.   European Journal of Trauma and Emergency Surgery

Heme as a danger molecule in pathogen recognition

(2015) Barbara Wegiel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

(2015) Ari B. Molofsky et al.   IMMUNITY

CNS Injury: IL-33 Sounds the Alarm

(2015) Simmie L. Foster et al.   IMMUNITY

The Calcium-binding Proteins S100A8 and S100A9 Initiate the Early Inflammatory Program in Injured Peripheral Nerves

(2015) Andrei V. Chernov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nlrp1 inflammasome is downregulated in trauma patients

(2015) B. Relja et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

(2015) Sachin P. Gadani et al.   NEURON

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

(2015) E. Suzanne Cohen et al.   Nature Communications

DAMPs from Cell Death to New Life

(2015) Emilie Vénéreau et al.   Frontiers in Immunology

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

(2014) Corinne Cayrol et al.   CURRENT OPINION IN IMMUNOLOGY

How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1

(2014) Peter A. Keyel   CYTOKINE

Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation

(2014) Juliana Bessa et al.   JOURNAL OF AUTOIMMUNITY

IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes

(2014) N. E. Humphreys et al.   JOURNAL OF IMMUNOLOGY

Overexpression of RAGE Contributes to Cigarette Smoke-Induced Nitric Oxide Generation in COPD

(2014) Lei Chen et al.   LUNG

Zytokine als Marker bei Polytrauma

(2014) M. van Griensven   UNFALLCHIRURG

Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development

(2014) Dominik J. Schaer et al.   Frontiers in Physiology

Role of advanced glycation end products in cellular signaling

(2014) Christiane Ott et al.   Redox Biology

Signalling C-Type lectin receptors, microbial recognition and immunity

(2013) J. Claire Hoving et al.   CELLULAR MICROBIOLOGY

Pathophysiologie des Polytraumas

(2013) S. Wutzler et al.   CHIRURG

Inflammasomes and host defenses against bacterial infections

(2013) Gregory I Vladimer et al.   CURRENT OPINION IN MICROBIOLOGY

Immune activation by histones: Plusses and minuses in inflammation

(2013) David S. Pisetsky   EUROPEAN JOURNAL OF IMMUNOLOGY

RAGE regulation and signaling in inflammation and beyond

(2013) Katrin Kierdorf et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The activation of HMGB1 as a progression factor on inflammation response in normal human bronchial epithelial cells through RAGE/JNK/NF-κB pathway

(2013) Xiaojin Wu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

RAGE and TLRs: Relatives, friends or neighbours?

(2013) Zaridatul Aini Ibrahim et al.   MOLECULAR IMMUNOLOGY

Extracellular cyclophilin A protects against blast-induced neuronal injury

(2013) Peethambaran Arun et al.   NEUROSCIENCE RESEARCH

Different Members of the IL-1 Family Come Out in Different Ways: DAMPs vs. Cytokines?

(2013) Sonia Carta et al.   Frontiers in Immunology

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The CARD plays a critical role in ASC foci formation and inflammasome signalling

(2012) Martina Proell et al.   BIOCHEMICAL JOURNAL

RAGE in tissue homeostasis, repair and regeneration

(2012) Guglielmo Sorci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain

(2012) M. Pichery et al.   JOURNAL OF IMMUNOLOGY

S100b as a Prognostic Biomarker in Outcome Prediction for Patients with Severe Traumatic Brain Injury

(2012) Akash Goyal et al.   JOURNAL OF NEUROTRAUMA

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology

(2012) Muhammad I. Arshad et al.   LIVER INTERNATIONAL

Danger Signals Activating the Immune Response after Trauma

(2012) Stefanie Hirsiger et al.   MEDIATORS OF INFLAMMATION

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles of trauma and transfusion in induction of immune modulation after injury

(2012) Rachael P. Jackman et al.   TRANSFUSION

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

(2012) Peleg Rider et al.   Frontiers in Immunology

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Trauma alarmins as activators of damage-induced inflammation

(2011) J. Manson et al.   BRITISH JOURNAL OF SURGERY

Epidemiology and risk factors of sepsis after multiple trauma: An analysis of 29,829 patients from the Trauma Registry of the German Society for Trauma Surgery*

(2011) Arasch Wafaisade et al.   CRITICAL CARE MEDICINE

A clinical perspective of IL-1β as the gatekeeper of inflammation

(2011) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice

(2011) Hai Huang et al.   HEPATOLOGY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury

(2011) J. W. Dear et al.   JOURNAL OF IMMUNOLOGY

The Role of Heat Shock Protein 70 in Mediating Age-Dependent Mortality in Sepsis

(2011) K. W. McConnell et al.   JOURNAL OF IMMUNOLOGY

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

High-Mobility Group Box 1, Oxidative Stress, and Disease

(2010) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Platelet interleukin-1  drives cerebrovascular inflammation

(2010) P. Thornton et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immune depression in musculoskeletal trauma

(2010) Olav Reikerås   INFLAMMATION RESEARCH

Epithelial Cells Promote Fibroblast Activation via IL-1α in Systemic Sclerosis

(2010) Nima Aden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

(2010) Jose C Alves-Filho et al.   NATURE MEDICINE

Interleukin-1α stimulates proinflammatory cytokine expression in human cardiac myofibroblasts

(2009) Neil A. Turner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Biomarkers in melanoma

(2009) H. Gogas et al.   ANNALS OF ONCOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis

(2009) Gaby Palmer et al.   ARTHRITIS AND RHEUMATISM

Targeting HMGB1 in inflammation

(2009) Huan Yang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Criteria for a Clinically Informative Serum Biomarker in Acute Ischaemic Stroke: A Review of S100B

(2009) Pooja Dassan et al.   CEREBROVASCULAR DISEASES

The receptor for advanced glycation endproducts (RAGE) and cardiovascular disease

(2009) Shi Fang Yan et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Macrophage suppression following phagocytosis of apoptotic neutrophils is mediated by the S100A9 calcium-binding protein

(2009) B.H.P. De Lorenzo et al.   IMMUNOBIOLOGY

Current theories on the pathophysiology of multiple organ failure after trauma

(2009) Takeshi Tsukamoto et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Heat shock proteins in neurodegenerative diseases: Pathogenic roles and therapeutic implications

(2009) Hiroaki Adachi et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

PULMONARY LEVELS OF HIGH-MOBILITY GROUP BOX 1 DURING MECHANICAL VENTILATION AND VENTILATOR-ASSOCIATED PNEUMONIA

(2009) Marieke A.D. van Zoelen et al.   SHOCK

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

The danger within: endogenous danger signals, atopy and asthma

(2008) M. A. M. Willart et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33

(2008) Gaby Palmer et al.   CYTOKINE

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A–H2B acidic pocket

(2008) Lucie Roussel et al.   EMBO REPORTS

IL-1, IL-18, and IL-33 families of cytokines

(2008) William P. Arend et al.   IMMUNOLOGICAL REVIEWS

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Gene profiling in human blood leucocytes during recovery from septic shock

(2008) Didier Payen et al.   INTENSIVE CARE MEDICINE

The prognostic value of serum S100B in patients with cutaneous melanoma: A meta-analysis

(2008) Simone Mocellin et al.   INTERNATIONAL JOURNAL OF CANCER

S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway

(2008) S. Ghavami et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY

Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease

(2008) Sanjay Sethi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compensatory anti-inflammatory response syndrome

(2008) Jean-Marc Cavaillon et al.   THROMBOSIS AND HAEMOSTASIS