Neurofilaments as biomarkers in neurological disorders

A motor neuron strategy to save time and energy in neurodegeneration: adaptive protein stoichiometry

(2018) Elisabetta Zucchi et al.   JOURNAL OF NEUROCHEMISTRY

Plasma neurofilament light chain concentration in the inherited peripheral neuropathies

(2018) Åsa Sandelius et al.   NEUROLOGY

Neurofilament light chain protein as a marker of neuronal injury: review of its use in HIV-1 infection and reference values for HIV-negative controls

(2017) Aylin Yilmaz et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Diagnosis of multiple sclerosis: progress and challenges

(2017) Wallace J Brownlee et al.   LANCET

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis

(2017) Lauren M Byrne et al.   LANCET NEUROLOGY

Diagnostic utility of cerebrospinal fluid α-synuclein in Parkinson's disease: A systematic review and meta-analysis

(2017) Paolo Eusebi et al.   MOVEMENT DISORDERS

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod

(2017) Fredrik Piehl et al.   Multiple Sclerosis Journal

CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults

(2017) Ane-Victoria Idland et al.   NEUROBIOLOGY OF AGING

Serum neurofilament light is sensitive to active cerebral small vessel disease

(2017) Thomas Gattringer et al.   NEUROLOGY

Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias

(2017) Petra Steinacker et al.   NEUROLOGY

Serum neurofilament light in familial Alzheimer disease

(2017) Philip S.J. Weston et al.   NEUROLOGY

Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease

(2017) Koen Poesen et al.   NEUROLOGY

Serum neurofilament is associated with progression of brain atrophy and disability in early MS

(2017) Jens Kuhle et al.   NEUROLOGY

Monitoring disease activity in multiple sclerosis using serum neurofilament light protein

(2017) Lenka Novakova et al.   NEUROLOGY

Blood-based NfL

(2017) Oskar Hansson et al.   NEUROLOGY

Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis

(2017) Emily Feneberg et al.   NEUROLOGY

Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports

(2017) Pashtun Shahim et al.   NEUROLOGY

Amyotrophic Lateral Sclerosis

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Neurofilaments and Neurofilament Proteins in Health and Disease

(2017) Aidong Yuan et al.   Cold Spring Harbor Perspectives in Biology

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease

(2017) Niklas Mattsson et al.   JAMA Neurology

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod

(2017) Fredrik Piehl et al.   Multiple Sclerosis Journal

Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa

(2016) Jens Kuhle et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease

(2016) Niklas Mattsson et al.   EMBO Molecular Medicine

Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple sclerosis

(2016) Lenka Novakova et al.   JOURNAL OF NEUROCHEMISTRY

Neurofilament light chain in FTD is elevated not only in cerebrospinal fluid, but also in serum

(2016) Carlo Wilke et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Serum Neurofilament Light in American Football Athletes over the Course of a Season

(2016) Jonathan M. Oliver et al.   JOURNAL OF NEUROTRAUMA

Phosphorylated neurofilament heavy chain levels in paired plasma and CSF of amyotrophic lateral sclerosis

(2016) Siyuan Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Amyotrophic lateral sclerosis: moving towards a new classification system

(2016) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Protein biomarkers in Parkinson's disease: Focus on cerebrospinal fluid markers and synaptic proteins

(2016) Steffen Halbgebauer et al.   MOVEMENT DISORDERS

Elevated CSF neurofilament proteins predict brain atrophy: A 15-year follow-up study

(2016) Axel Petzold et al.   Multiple Sclerosis Journal

Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis

(2016) Lenka Novakova et al.   Multiple Sclerosis Journal

Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity

(2016) Jens Kuhle et al.   Multiple Sclerosis Journal

Brain MRI atrophy quantification in MS

(2016) Maria A. Rocca et al.   NEUROLOGY

Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia

(2016) Jonathan D. Rohrer et al.   NEUROLOGY

Neurofilament light chain level is a weak risk factor for the development of MS

(2016) Georgina Arrambide et al.   NEUROLOGY

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

(2016) Mehtap Bacioglu et al.   NEURON

Neurofilament Light: A Dynamic Cross-Disease Fluid Biomarker for Neurodegeneration

(2016) Henrik Zetterberg   NEURON

Intermediate Filaments: Structure and Assembly

(2016) Harald Herrmann et al.   Cold Spring Harbor Perspectives in Biology

Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS

(2016) Patrick Oeckl et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Diagnostic and prognostic significance of neurofilament light chain NF-L, but not progranulin and S100B, in the course of amyotrophic lateral sclerosis: Data from the German MND-net

(2016) Petra Steinacker et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression

(2016) Henrik Zetterberg et al.   JAMA Neurology

Elevated CSF neurofilament proteins predict brain atrophy: A 15-year follow-up study

(2016) Axel Petzold et al.   Multiple Sclerosis Journal

Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis

(2016) Lenka Novakova et al.   Multiple Sclerosis Journal

Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity

(2016) Jens Kuhle et al.   Multiple Sclerosis Journal

Traumatic brain injuries

(2016) Kaj Blennow et al.   Nature Reviews Disease Primers

Plasma neurofilament light chain predicts progression in progressive supranuclear palsy

(2016) Julio C. Rojas et al.   Annals of Clinical and Translational Neurology

Neurofilament light chain: a biomarker for genetic frontotemporal dementia

(2016) Lieke H. Meeter et al.   Annals of Clinical and Translational Neurology

Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study

(2016) Magnus Gisslén et al.   EBioMedicine

Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease

(2016) Petra Steinacker et al.   Scientific Reports

Serum neurofilament light protein predicts clinical outcome in traumatic brain injury

(2016) Pashtun Shahim et al.   Scientific Reports

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

(2015) Ann C. McKee et al.   ACTA NEUROPATHOLOGICA

Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis

(2015) Patrick Weydt et al.   ANNALS OF NEUROLOGY

Serum Neurofilament Light Chain Levels Are Associated with Clinical Characteristics and Outcome in Patients with Cervical Artery Dissection

(2015) Christopher Traenka et al.   CEREBROVASCULAR DISEASES

Neurofilament medium polypeptide (NFM) protein concentration is increased in CSF and serum samples from patients with brain injury

(2015) Eduardo Martínez-Morillo et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes

(2015) N K Magdalinou et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Serial measurements of phosphorylated neurofilament-heavy in the serum of subjects with amyotrophic lateral sclerosis

(2015) P.A. McCombe et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis

(2015) C.-H. Lu et al.   NEUROLOGY

Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis

(2015) J. Kuhle et al.   NEUROLOGY

Comparative Assessment of the Prognostic Value of Biomarkers in Traumatic Brain Injury Reveals an Independent Role for Serum Levels of Neurofilament Light

(2015) Faiez Al Nimer et al.   PLoS One

Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome

(2014) J. Kuhle et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Natalizumab in progressive MS: Results of an open-label, phase 2A, proof-of-concept trial

(2014) J. Romme Christensen et al.   NEUROLOGY

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival

(2014) T. Skillback et al.   NEUROLOGY

Elevated Concentrations of Neurofilament Light Chain in the Cerebrospinal Fluid of Bipolar Disorder Patients

(2014) Joel Jakobsson et al.   NEUROPSYCHOPHARMACOLOGY

Immunosuppressive therapy reduces axonal damage in progressive multiple sclerosis

(2013) Markus Axelsson et al.   Multiple Sclerosis Journal

Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers

(2013) Steven T. DeKosky et al.   Nature Reviews Neurology

Increased Neurofilament Light Chain Blood Levels in Neurodegenerative Neurological Diseases

(2013) Johanna Gaiottino et al.   PLoS One

Accuracy of a Panel of 5 Cerebrospinal Fluid Biomarkers in the Differential Diagnosis of Patients With Dementia and/or Parkinsonian Disorders

(2012) Sara Hall et al.   ARCHIVES OF NEUROLOGY

Structures and interactions in ‘bottlebrush’ neurofilaments: the role of charged disordered proteins in forming hydrogel networks

(2012) Roy Beck et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interpreting Magnetic Resonance Imaging Findings in Bipolar Disorder

(2012) David A. Cousins et al.   CNS Neuroscience & Therapeutics

Phosphorylated neurofilament heavy subunit (pNF-H) in peripheral blood and CSF as a potential prognostic biomarker in amyotrophic lateral sclerosis

(2012) K. B. Boylan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Expansion of Neurofilament Medium C Terminus Increases Axonal Diameter Independent of Increases in Conduction Velocity or Myelin Thickness

(2012) D. M. Barry et al.   JOURNAL OF NEUROSCIENCE

CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome

(2012) M Khalil et al.   Multiple Sclerosis Journal

CSF-Biomarkers in Olympic Boxing: Diagnosis and Effects of Repetitive Head Trauma

(2012) Sanna Neselius et al.   PLoS One

Neurofilament heavy subunit in cerebrospinal fluid: A biomarker of amyotrophic lateral sclerosis?

(2011) Deise M. F. Mendonça et al.   Amyotrophic Lateral Sclerosis

In vivo monitoring of neuronal loss in traumatic brain injury: a microdialysis study

(2011) Axel Petzold et al.   BRAIN

Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosis

(2011) J. Kuhle et al.   NEUROLOGY

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab

(2010) Martin Gunnarsson et al.   ANNALS OF NEUROLOGY

A highly sensitive electrochemiluminescence immunoassay for the neurofilament heavy chain protein

(2010) Jens Kuhle et al.   JOURNAL OF NEUROIMMUNOLOGY

Neurofilament light chain levels in ventricular cerebrospinal fluid after acute aneurysmal subarachnoid haemorrhage

(2010) E. R. Zanier et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis

(2010) Emma C Tallantyre et al.   Multiple Sclerosis Journal

Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations

(2010) David M Rissin et al.   NATURE BIOTECHNOLOGY

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)

(2009) Kathryn Volkening et al.   BRAIN RESEARCH

EFNS guidelines on disease-specific CSF investigations

(2009) F. Deisenhammer et al.   EUROPEAN JOURNAL OF NEUROLOGY

Neurofilament ELISA validation

(2009) Axel Petzold et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis

(2009) C. E. Teunissen et al.   NEUROLOGY

Post-transcriptional control of neurofilaments: New roles in development, regeneration and neurodegenerative disease

(2009) Ben G. Szaro et al.   TRENDS IN NEUROSCIENCES

Detection of Phosphorylated NF-H in the Cerebrospinal Fluid and Blood of Aneurysmal Subarachnoid Hemorrhage Patients

(2008) Stephen B Lewis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments

(2008) Ruth Huizinga et al.   NEUROBIOLOGY OF DISEASE

Levels of the light subunit of neurofilament triplet protein in cerebrospinal fluid in Huntington's disease

(2008) Radu Constantinescu et al.   PARKINSONISM & RELATED DISORDERS