ADAM17, A Key Player of Cardiac Inflammation and Fibrosis in Heart Failure Development During Chronic Catecholamine Stress

Contribution of ADAM17 and related ADAMs in cardiovascular diseases

(2021) Tatsuo Kawai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution

(2021) Matteo Calligaris et al.   MOLECULES

Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling

(2021) Icia Santos-Zas et al.   Nature Communications

β1-adrenergic receptor N-terminal cleavage by ADAM17; the mechanism for redox-dependent downregulation of cardiomyocyte β1-adrenergic receptors

(2021) Jing Zhu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene

(2021) Shengqi Huo et al.   Oxidative Medicine and Cellular Longevity

Role of Neutrophils in Cardiac Injury and Repair Following Myocardial Infarction

(2021) Yonggang Ma   Cells

The Synergy of ADAM17-Induced Myocardial Inflammation and Metabolic Lipids Dysregulation During Acute Stress: New Pathophysiologic Insights Into Takotsubo Cardiomyopathy

(2021) Joseph Adu-Amankwaah et al.   Frontiers in Cardiovascular Medicine

Estrogen Attenuates Chronic Stress-Induced Cardiomyopathy by Adaptively Regulating Macrophage Polarizations via β2-Adrenergic Receptor Modulation

(2021) Hongjian Hou et al.   Frontiers in Cell and Developmental Biology

Amlexanox and Forskolin Prevents Isoproterenol-Induced Cardiomyopathy by Subduing Cardiomyocyte Hypertrophy and Maladaptive Inflammatory Responses

(2021) Gabriel Komla Adzika et al.   Frontiers in Cell and Developmental Biology

Predominance of Heart Failure With Preserved Ejection Fraction in Postmenopausal Women: Intra- and Extra-Cardiomyocyte Maladaptive Alterations Scaffolded by Estrogen Deficiency

(2021) Adebayo Oluwafemi Adekunle et al.   Frontiers in Cell and Developmental Biology

Inhibition of Dectin-1 in mice ameliorates cardiac remodeling by suppressing NF-κB/NLRP3 signaling after myocardial infarction

(2020) Xin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Reappraising the role of inflammation in heart failure

(2020) Luigi Adamo et al.   Nature Reviews Cardiology

Role of Endothelial ADAM17 in Early Vascular Changes Associated with Diabetic Retinopathy

(2020) Lamiaa Shalaby et al.   Journal of Clinical Medicine

The cardiovascular aspect of COVID-19

(2020) Joseph Adu-Amankwaah et al.   ANNALS OF MEDICINE

Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair

(2020) William P. Lafuse et al.   Cells

Circadian Expression of TIMP3 Is Disrupted by UVB Irradiation and Recovered by Green Tea Extracts

(2019) Sunyoung Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes

(2019) Jeremiah Ong’achwa Machuki et al.   Cell Communication and Signaling

Pathological cardiac hypertrophy: the synergy of adenylyl cyclases inhibition in cardiac and immune cells during chronic catecholamine stress

(2019) Gabriel Komla Adzika et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The metalloprotease ADAM17 in inflammation and cancer

(2019) Stefan Düsterhöft et al.   PATHOLOGY RESEARCH AND PRACTICE

Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)

(2019) Giorgia Schena et al.   Cells

Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage

(2019) Rielana Wichert et al.   FASEB JOURNAL

What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?

(2019) Benedict C. Albensi   Frontiers in Cell and Developmental Biology

ACE2 and ADAM17 Interaction Regulates the Activity of Presympathetic Neurons

(2019) Snigdha Mukerjee et al.   HYPERTENSION

Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy

(2019) Michinari Hieda et al.   CIRCULATION

Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR-dependent pathway

(2018) Liang Liu et al.   BASIC RESEARCH IN CARDIOLOGY

Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments

(2018) Stefan F Lichtenthaler et al.   EMBO JOURNAL

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC

(2018) Stefan Frantz et al.   EUROPEAN JOURNAL OF HEART FAILURE

Interleukin-6: designing specific therapeutics for a complex cytokine

(2018) Christoph Garbers et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanism and Therapies of Oxidative Stress-Mediated Cell Death in Ischemia Reperfusion Injury

(2018) Haobo Li et al.   Oxidative Medicine and Cellular Longevity

Estrogen deficiency compromised the β2AR-Gs/Gi coupling: implications for arrhythmia and cardiac injury

(2018) Hongjian Hou et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells

(2018) Anne-Sophie Cabron et al.   JOURNAL OF IMMUNOLOGY

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage

(2018) Sandra Rayego-Mateos et al.   MEDIATORS OF INFLAMMATION

Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling–Induced Nontranscriptional Priming of the NLRP3 Inflammasome

(2017) Yue Xing et al.   JOURNAL OF IMMUNOLOGY

Effects of stress on the development and progression of cardiovascular disease

(2017) Mika Kivimäki et al.   Nature Reviews Cardiology

Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation

(2017) Samantha Arokiasamy et al.   Scientific Reports

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

(2017) Steffen Riethmueller et al.   PLOS BIOLOGY

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

(2017) Adam Graham Grieve et al.   eLife

Current Drug Therapy in Chronic Heart Failure: the New Guidelines of the European Society of Cardiology (ESC)

(2017) Dominik Berliner et al.   Korean Circulation Journal

The role of ADAM17 in the T-cell response against bacterial pathogens

(2017) Moritz Andreas Link et al.   PLoS One

ADAM Proteases and Gastrointestinal Function

(2016) Jennifer C. Jones et al.   Annual Review of Physiology

Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and DysfunctionNovelty and Significance

(2016) Lin Zhao et al.   CIRCULATION RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression

(2016) Eunsoo Won et al.   Current Neuropharmacology

ADAMs family and relatives in cardiovascular physiology and pathology

(2016) Pu Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Circulating Levels of IL‐6 Receptor and gp130 and Long‐Term Clinical Outcomes in ST‐Elevation Myocardial Infarction

(2016) Vibeke N. Ritschel et al.   Journal of the American Heart Association

α-LIPOIC ACID REDUCES NEUROGENIC HYPERTENSION BY BLUNTING OXIDATIVE STRESS-MEDIATED INCREASE IN ADAM17

(2015) Thyago M de Queiroz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Adam17, a Target of Mir-326, Promotes Emt-Induced Cells Invasion in Lung Adenocarcinoma

(2015) Ming Cai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The varying faces of IL-6: From cardiac protection to cardiac failure

(2015) Jillian A. Fontes et al.   CYTOKINE

Myocardial interstitial remodelling in non-ischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance

(2015) Andrea Barison et al.   HEART FAILURE REVIEWS

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adrenergic regulation of innate immunity: a review

(2015) Angela Scanzano et al.   Frontiers in Pharmacology

MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients

(2015) Kai Doberstein et al.   NEOPLASIA

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

(2014) Timo Heidt et al.   CIRCULATION RESEARCH

Interleukin-6 and its receptors: A highly regulated and dynamic system

(2014) Janina Wolf et al.   CYTOKINE

MicroRNA-152 targets ADAM17 to suppress NSCLC progression

(2014) Yunshu Su et al.   FEBS LETTERS

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor

(2014) Stefan Düsterhöft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Metalloproteinase ADAM17 in Regulating ICOS Ligand–Mediated Humoral Immune Responses

(2014) Joanna Marczynska et al.   JOURNAL OF IMMUNOLOGY

Regulation of CXCR2 expression and function by a disintegrin and metalloprotease-17 (ADAM17)

(2014) Hemant K. Mishra et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Behavior of Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptor 1/Tumor Necrosis Factor Receptor 2 System in Mononuclear Cells Recovered From Peritoneal Fluid of Women With Endometriosis at Different Stages

(2014) Francesca M. Salmeri et al.   Reproductive Sciences

Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo

(2014) Helen L. Wright et al.   RHEUMATOLOGY

Amphiregulin

(2014) Carmen Berasain et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

(2013) Claudia Broder et al.   BIOCHEMICAL JOURNAL

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17

(2013) Jeanette Schwarz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines

(2013) Yang Sun et al.   CELL RESEARCH

IL-6 and its receptors in coronary artery disease and acute myocardial infarction

(2013) Daniel R. Anderson et al.   CYTOKINE

Importance of reverse signaling of the TNF superfamily in immune regulation

(2013) Kata Juhász et al.   Expert Review of Clinical Immunology

ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with αvβ6 integrin

(2013) Adam V. Jones et al.   FEBS LETTERS

B Cell Production of Tumor Necrosis Factor in Response to Pneumocystis murina Infection in Mice

(2013) Michael M. Opata et al.   INFECTION AND IMMUNITY

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

(2013) Priya Darshinee A. Issuree et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble Tumor Necrosis Factor Receptors Shed by Breast Tumor Cells Inhibit Macrophage Chemotaxis

(2013) Stephen Lee Rego et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Membrane-Proximal Domain of a Disintegrin and Metalloprotease-17 Represents the Putative Molecular Switch of Its Shedding Activity Operated by Protein-disulfide Isomerase

(2013) Stefan Düsterhöft et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Induction of Tumor Necrosis Factor (TNF) Release from Subtypes of T Cells by Agonists of Proteinase Activated Receptors

(2013) Haiwei Yang et al.   MEDIATORS OF INFLAMMATION

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β 2 -Adrenergic Receptor/G i –Dependent Manner

(2012) Helen Paur et al.   CIRCULATION

Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice

(2012) N Chin Lai et al.   LABORATORY INVESTIGATION

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms

(2012) Colin Adrain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

(2012) P. Xu et al.   Science Signaling

ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate cancer cell invasion

(2011) Xiao-Guang Yu   INTERNATIONAL JOURNAL OF ONCOLOGY

Fibroblasts and Myofibroblasts: What Are We Talking About?

(2011) Jennifer Baum et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

ADAM-17 Is Activated by the Mitogenic Protein Kinase ERK in a Model of Kidney Fibrosis

(2010) L. Gabriel Navar et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17

(2010) Sofie H. Willems et al.   BIOCHEMICAL JOURNAL

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Activation of p38 mitogen-activated protein kinase by norepinephrine in T-lineage cells

(2010) Melissa D. LaJevic et al.   IMMUNOLOGY

Loss of CD4 + T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells

(2010) Gareth W. Jones et al.   JOURNAL OF IMMUNOLOGY

The metzincins - Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc-peptidases

(2010) Walter Stöcker et al.   PROTEIN SCIENCE

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Signaling pathways mediating β3-adrenergic receptor-induced production of interleukin-6 in adipocytes

(2009) Inna E. Tchivileva et al.   MOLECULAR IMMUNOLOGY

Selectivity of the NF- B Response

(2009) R. Sen et al.   Cold Spring Harbor Perspectives in Biology

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

Role of the Chemokine Receptor CXCR2 in Bleomycin-Induced Pulmonary Inflammation and Fibrosis

(2008) Remo C. Russo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects

(2008) P Fischer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tumor Necrosis Factor-α and Mortality in Heart Failure

(2008) Shannon M. Dunlay et al.   CIRCULATION

Aldose Reductase Regulates High Glucose-Induced Ectodomain Shedding of Tumor Necrosis Factor (TNF)-α via Protein Kinase C-δ and TNF-α Converting Enzyme in Vascular Smooth Muscle Cells

(2008) Aramati B. M. Reddy et al.   ENDOCRINOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY