Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells

Invadosomes are coming: new insights into function and disease relevance

(2017) Elyse K. Paterson et al.   FEBS Journal

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17

(2016) Steffen Riethmueller et al.   Scientific Reports

The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site

(2015) Eitan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity

(2015) Anna Baruzzi et al.   JOURNAL OF IMMUNOLOGY

ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses

(2015) Isabell Yan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Induction of Inflammation by Dectin-1 In Vivo Is Dependent on Myeloid Cell Programming and the Progression of Phagocytosis

(2014) M. Rosas et al.   JOURNAL OF IMMUNOLOGY

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17

(2013) Jeanette Schwarz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Polo-like Kinase 2, a Novel ADAM17 Signaling Component, Regulates Tumor Necrosis Factor α Ectodomain Shedding

(2013) Jeanette Schwarz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

(2013) Masaki Yoda et al.   PLoS One

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells

(2012) Kosuke Yamamoto et al.   BIOCHEMICAL JOURNAL

Tumor Necrosis Factor-α Signaling in Macrophages

(2012) Narayanan Parameswaran et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Interleukin-1 Stimulates ADAM17 through a Mechanism Independent of its Cytoplasmic Domain or Phosphorylation at Threonine 735

(2012) Katherine C. Hall et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog

(2011) Theodoros Goulas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17

(2011) Thorsten Maretzky et al.   Nature Communications

Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells

(2010) Marcela Rosas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

(2010) Athena Chalaris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Double-Stranded RNA Induces Shedding of the 34-kDa Soluble TNFR1 from Human Airway Epithelial Cells via TLR3-TRIF-RIP1-Dependent Signaling: Roles for Dual Oxidase 2- and Caspase-Dependent Pathways

(2010) M. Yu et al.   JOURNAL OF IMMUNOLOGY

In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli -mediated peritonitis

(2010) Chunmei Long et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation

(2010) Pinglong Xu et al.   MOLECULAR CELL

Regulation of Mature ADAM17 by Redox Agents for L-Selectin Shedding

(2009) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Actin cytoskeletal organisation in osteoclasts: A model to decipher transmigration and matrix degradation

(2008) F SALTEL et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

TLR ligand–induced podosome disassembly in dendritic cells is ADAM17 dependent

(2008) Michele A. West et al.   JOURNAL OF CELL BIOLOGY