Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo

IL-6 plays an essential role in neutrophilia under inflammation

(2011) Misato Hashizume et al.   CYTOKINE

Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy

(2011) H. L. Wright et al.   RHEUMATOLOGY

Changes in expression of membrane TNF, NF- B activation and neutrophil apoptosis during active and resolved inflammation

(2010) H. L. Wright et al.   ANNALS OF THE RHEUMATIC DISEASES

Population Pharmacokinetic Analysis of Tocilizumab in Patients With Rheumatoid Arthritis

(2010) Nicolas Frey et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Neutropenia in patients receiving anti-tumor necrosis factor therapy

(2010) Richard Hastings et al.   ARTHRITIS CARE & RESEARCH

Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

(2009) G. Jones et al.   ANNALS OF THE RHEUMATIC DISEASES

Blockade of Interleukin 6 Signaling Induces Marked Neutropenia in Patients with Rheumatoid Arthritis

(2009) I. NAKAMURA et al.   JOURNAL OF RHEUMATOLOGY

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study

(2008) Mark C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

(2008) Josef S Smolen et al.   LANCET

IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice

(2007) F. Walker et al.   BLOOD