Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
Authors
Keywords
-
Journal
Frontiers in Cell and Developmental Biology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-11-15
DOI
10.3389/fcell.2021.745311
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins
- (2021) Ondrej Belan et al. MOLECULAR CELL
- The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination
- (2021) Upasana Roy et al. MOLECULAR CELL
- Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway
- (2021) Benjamin M. Stinson et al. Annual Review of Biochemistry
- Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis
- (2021) Robin Öz et al. NUCLEIC ACIDS RESEARCH
- Multicolor single-molecule FRET for DNA and RNA processes
- (2021) Xinyu A. Feng et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- 53BP1: a DSB escort
- (2020) Zachary Mirman et al. GENES & DEVELOPMENT
- Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system
- (2020) Bailin Zhao et al. NUCLEIC ACIDS RESEARCH
- DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP
- (2020) Rajashree A. Deshpande et al. Science Advances
- Single-Molecule Studies of Protein Folding with Optical Tweezers
- (2020) Carlos Bustamante et al. Annual Review of Biochemistry
- RAD51 Gene Family Structure and Function
- (2020) Braulio Bonilla et al. Annual Review of Genetics
- Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination
- (2020) J. Brooks Crickard et al. CELL
- The molecular basis and disease relevance of non-homologous DNA end joining
- (2020) Bailin Zhao et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break
- (2020) Andrea M. Kaminski et al. Nature Communications
- Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates
- (2020) Chaoyou Xue et al. NUCLEIC ACIDS RESEARCH
- Regulatory control of Sgs1 and Dna2 during eukaryotic DNA end resection
- (2019) Chaoyou Xue et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments
- (2019) J Brooks Crickard et al. NUCLEIC ACIDS RESEARCH
- Dynamics and selective remodeling of the DNA-binding domains of RPA
- (2019) Nilisha Pokhrel et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RPA Phosphorylation Inhibits DNA Resection
- (2019) Michael M. Soniat et al. MOLECULAR CELL
- Competing interaction partners modulate the activity of Sgs1 helicase during DNA end resection
- (2019) Kristina Kasaciunaite et al. EMBO JOURNAL
- DNA double-strand break repair-pathway choice in somatic mammalian cells
- (2019) Ralph Scully et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A modular DNA scaffold to study protein–protein interactions at single-molecule resolution
- (2019) Dorota Kostrz et al. Nature Nanotechnology
- Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates
- (2019) Chaoyou Xue et al. NUCLEIC ACIDS RESEARCH
- The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis
- (2019) Bailin Zhao et al. Nature Communications
- A Mechanism to Minimize Errors during Non-homologous End Joining
- (2019) Benjamin M. Stinson et al. MOLECULAR CELL
- DNA Repair: The Search for Homology
- (2018) James E. Haber BIOESSAYS
- Dissection of DNA double-strand-break repair using novel single-molecule forceps
- (2018) Jing L. Wang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Dissection of DNA double-strand-break repair using novel single-molecule forceps
- (2018) Jing L. Wang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Single-molecule localization microscopy as a promising tool for γH2AX/53BP1 foci exploration
- (2018) Daniel Depes et al. EUROPEAN PHYSICAL JOURNAL D
- A single XLF dimer bridges DNA ends during nonhomologous end joining
- (2018) Thomas G. W. Graham et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Recruitment of 53BP1 Proteins for DNA Repair and Persistence of Repair Clusters Differ for Cell Types as Detected by Single Molecule Localization Microscopy
- (2018) Elizaveta Bobkova et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase
- (2018) J. Brooks Crickard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human RAD52 interactions with replication protein A and the RAD51 presynaptic complex
- (2017) Chu Jian Ma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair
- (2017) Logan R. Myler et al. MOLECULAR CELL
- BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing
- (2017) Weixing Zhao et al. NATURE
- The control of DNA repair by the cell cycle
- (2017) Nicole Hustedt et al. NATURE CELL BIOLOGY
- Non-homologous DNA end joining and alternative pathways to double-strand break repair
- (2017) Howard H. Y. Chang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Sequential eviction of crowded nucleoprotein complexes by the exonuclease RecBCD molecular motor
- (2017) Tsuyoshi Terakawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining
- (2017) Michael P. Conlin et al. Cell Reports
- Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous Recombination Regulation
- (2017) Luisina De Tullio et al. Cell Reports
- Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2
- (2017) Kyle Kaniecki et al. Cell Reports
- Eukaryotic DNA Polymerases in Homologous Recombination
- (2016) Mitch McVey et al. Annual Review of Genetics
- Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency
- (2016) Howard H. Y. Chang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Two-Stage Synapsis of DNA Ends during Non-homologous End Joining
- (2016) Thomas G.W. Graham et al. MOLECULAR CELL
- Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection
- (2016) Roopesh Anand et al. MOLECULAR CELL
- Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA
- (2016) Ineke Brouwer et al. NATURE
- Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection
- (2016) Ruth M Densham et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry
- (2016) Dylan A. Reid et al. NUCLEIC ACIDS RESEARCH
- Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament
- (2016) Chu Jian Ma et al. NUCLEIC ACIDS RESEARCH
- Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins
- (2016) Logan R. Myler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination
- (2016) Jérôme Loc'h et al. STRUCTURE
- Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection
- (2016) Ruth M Densham et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex
- (2016) Fengshan Liang et al. Cell Reports
- PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF
- (2016) Satish K. Tadi et al. Cell Reports
- Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination
- (2015) Martin R.G. Taylor et al. CELL
- DNA Sequence Alignment by Microhomology Sampling during Homologous Recombination
- (2015) Zhi Qi et al. CELL
- Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
- (2015) Wenxia Jiang et al. MOLECULAR CELL
- Active displacement of RecA filaments by UvrD translocase activity
- (2015) Vessela Petrova et al. NUCLEIC ACIDS RESEARCH
- Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair
- (2015) Dylan A. Reid et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
- (2015) Nicholas Jette et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
- (2015) T. Ochi et al. SCIENCE
- Base triplet stepping by the Rad51/RecA family of recombinases
- (2015) J. Y. Lee et al. SCIENCE
- Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway
- (2015) Mengtan Xing et al. Nature Communications
- DNA double-strand break repair pathway choice and cancer
- (2014) Tomas Aparicio et al. DNA REPAIR
- Holliday junction resolution: Regulation in space and time
- (2014) Joao Matos et al. DNA REPAIR
- DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells
- (2014) Andreas Sturzenegger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Diffusion of Human Replication Protein A along Single-Stranded DNA
- (2014) Binh Nguyen et al. JOURNAL OF MOLECULAR BIOLOGY
- Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks
- (2014) Elda Cannavo et al. NATURE
- Mechanisms and principles of homology search during recombination
- (2014) Jörg Renkawitz et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Protein dynamics during presynaptic-complex assembly on individual single-stranded DNA molecules
- (2014) Bryan Gibb et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RPA antagonizes microhomology-mediated repair of DNA double-strand breaks
- (2014) Sarah K Deng et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Concentration-Dependent Exchange of Replication Protein A on Single-Stranded DNA Revealed by Single-Molecule Imaging
- (2014) Bryan Gibb et al. PLoS One
- Top3α Is Required during the Convergent Migration Step of Double Holliday Junction Dissolution
- (2014) Stefanie Hartman Chen et al. PLoS One
- The Dissolution of Double Holliday Junctions
- (2014) A. H. Bizard et al. Cold Spring Harbor Perspectives in Biology
- Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair
- (2014) A. Mehta et al. Cold Spring Harbor Perspectives in Biology
- The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining
- (2014) Crystal A. Waters et al. Nature Communications
- 53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions
- (2013) Elsa Callen et al. CELL
- Role of Replication Protein A in Double Holliday Junction Dissolution Mediated by the BLM-Topo IIIα-RMI1-RMI2 Protein Complex
- (2013) Xiaoyu Xue et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A noncatalytic function of the ligation complex during nonhomologous end joining
- (2013) Jessica Cottarel et al. JOURNAL OF CELL BIOLOGY
- Monitoring Homology Search during DNA Double-Strand Break Repair In Vivo
- (2013) Jörg Renkawitz et al. MOLECULAR CELL
- DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
- (2013) Atsushi Shibata et al. MOLECULAR CELL
- 53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection
- (2013) M. Zimmermann et al. SCIENCE
- Srs2 prevents Rad51 filament formation by repetitive motion on DNA
- (2013) Yupeng Qiu et al. Nature Communications
- The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair
- (2013) Hailong Wang et al. PLoS Genetics
- Single-Stranded DNA Curtains for Real-Time Single-Molecule Visualization of Protein–Nucleic Acid Interactions
- (2012) Bryan Gibb et al. ANALYTICAL CHEMISTRY
- Recent Advances in Magnetic Tweezers
- (2012) Iwijn De Vlaminck et al. Annual Review of Biophysics
- Photophysics of Fluorescent Probes for Single-Molecule Biophysics and Super-Resolution Imaging
- (2012) Taekjip Ha et al. Annual Review of Physical Chemistry
- XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair
- (2012) Brandi L. Mahaney et al. Biochemistry and Cell Biology
- BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair
- (2012) J. R. Chapman et al. JOURNAL OF CELL SCIENCE
- Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs
- (2012) Shruti Malu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Single-molecule analysis of DNA replication in Xenopus egg extracts
- (2012) Hasan Yardimci et al. METHODS
- How RecBCD Enzyme and Chi Promote DNA Break Repair and Recombination: a Molecular Biologist's View
- (2012) G. R. Smith MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- Activation of DSB Processing Requires Phosphorylation of CtIP by ATR
- (2012) Shaun E. Peterson et al. MOLECULAR CELL
- Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA
- (2012) Jason C. Bell et al. NATURE
- Single-molecule imaging of DNA pairing by RecA reveals a three-dimensional homology search
- (2012) Anthony L. Forget et al. NATURE
- A human XRCC4–XLF complex bridges DNA
- (2012) Sara N. Andres et al. NUCLEIC ACIDS RESEARCH
- Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining
- (2012) Pablo De Ioannes et al. Cell Reports
- RecA filament sliding on DNA facilitates homology search
- (2012) Kaushik Ragunathan et al. eLife
- Double-Strand Break End Resection and Repair Pathway Choice
- (2011) Lorraine S. Symington et al. Annual Review of Genetics
- Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination
- (2011) Shannon J. Ceballos et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- SSB Functions as a Sliding Platform that Migrates on DNA via Reptation
- (2011) Ruobo Zhou et al. CELL
- Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities
- (2011) Marek Sebesta et al. DNA REPAIR
- BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
- (2011) A. V. Nimonkar et al. GENES & DEVELOPMENT
- hSWS1·SWSAP1 Is an Evolutionarily Conserved Complex Required for Efficient Homologous Recombination Repair
- (2011) Ting Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair
- (2011) Michal Hammel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase
- (2011) Kara A. Bernstein et al. MOLECULAR BIOLOGY OF THE CELL
- Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation
- (2011) Jie Liu et al. NATURE
- Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining
- (2011) V. Ropars et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
- (2010) Michael R. Lieber Annual Review of Biochemistry
- PcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps
- (2010) Jeehae Park et al. CELL
- 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
- (2010) Samuel F. Bunting et al. CELL
- DNA end resection by CtIP and exonuclease 1 prevents genomic instability
- (2010) Wassim Eid et al. EMBO REPORTS
- Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae
- (2010) Hengyao Niu et al. NATURE
- DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2
- (2010) Petr Cejka et al. NATURE
- Single-molecule imaging reveals mechanisms of protein disruption by a DNA translocase
- (2010) Ilya J. Finkelstein et al. NATURE
- Purified human BRCA2 stimulates RAD51-mediated recombination
- (2010) Ryan B. Jensen et al. NATURE
- Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1–Top3
- (2010) Petr Cejka et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2
- (2010) Eloïse Dray et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Concentration-dependent exchange accelerates turnover of proteins bound to double-stranded DNA
- (2010) J. S. Graham et al. NUCLEIC ACIDS RESEARCH
- XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex
- (2010) Michal Hammel et al. STRUCTURE
- Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex
- (2009) Michal Hammel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4
- (2009) P.-Y. Wu et al. MOLECULAR AND CELLULAR BIOLOGY
- PCNA Is Required for Initiation of Recombination-Associated DNA Synthesis by DNA Polymerase δ
- (2009) Xuan Li et al. MOLECULAR CELL
- Srs2 Disassembles Rad51 Filaments by a Protein-Protein Interaction Triggering ATP Turnover and Dissociation of Rad51 from DNA
- (2009) Edwin Antony et al. MOLECULAR CELL
- DNA double-strand breaks: Their production, recognition, and repair in eukaryotes
- (2009) Takeo Ohnishi et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- SSB protein diffusion on single-stranded DNA stimulates RecA filament formation
- (2009) Rahul Roy et al. NATURE
- DNA Damage, Aging, and Cancer
- (2009) Jan H.J. Hoeijmakers NEW ENGLAND JOURNAL OF MEDICINE
- Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules
- (2009) J. Hilario et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanism of Eukaryotic Homologous Recombination
- (2008) Joseph San Filippo et al. Annual Review of Biochemistry
- Recent Advances in Optical Tweezers
- (2008) Jeffrey R. Moffitt et al. Annual Review of Biochemistry
- Parallel Arrays of Geometric Nanowells for Assembling Curtains of DNA with Controlled Lateral Dispersion
- (2008) Mari-Liis Visnapuu et al. LANGMUIR
- RecBCD Enzyme and the Repair of Double-Stranded DNA Breaks
- (2008) M. S. Dillingham et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- A practical guide to single-molecule FRET
- (2008) Rahul Roy et al. NATURE METHODS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search