Regulatory control of Sgs1 and Dna2 during eukaryotic DNA end resection

Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

(2018) Bryan A Leland et al.   eLife

A novel role of the Dna2 translocase function in DNA break resection

(2017) Adam S. Miller et al.   GENES & DEVELOPMENT

Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles

(2017) Weibin Wang et al.   GENES & DEVELOPMENT

Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection

(2017) Giordano Reginato et al.   GENES & DEVELOPMENT

The INO80 Complex Removes H2A.Z to Promote Presynaptic Filament Formation during Homologous Recombination

(2017) Claudio A. Lademann et al.   Cell Reports

Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP

(2017) James M. Daley et al.   Cell Reports

Mechanism and regulation of DNA end resection in eukaryotes

(2016) Lorraine S. Symington   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

When Genome Maintenance Goes Badly Awry

(2016) Elizabeth M. Kass et al.   MOLECULAR CELL

Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases

(2016) Cosimo Pinto et al.   eLife

Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics

(2015) Massimo Bogliolo et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Chromatin dynamics after DNA damage: The legacy of the access–repair–restore model

(2015) Sophie E. Polo et al.   DNA REPAIR

Biochemical mechanism of DSB end resection and its regulation

(2015) James M. Daley et al.   DNA REPAIR

Removal of H2A.Z by INO80 promotes homologous recombination

(2015) H. E. Alatwi et al.   EMBO REPORTS

Single-molecule visualization of RecQ helicase reveals DNA melting, nucleation, and assembly are required for processive DNA unwinding

(2015) Behzad Rad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

Meiotic Recombination: The Essence of Heredity

(2015) Neil Hunter   Cold Spring Harbor Perspectives in Biology

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Human RecQ Helicases in DNA Repair, Recombination, and Replication

(2014) Deborah L. Croteau et al.   Annual Review of Biochemistry

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

DNA double-strand break repair pathway choice and cancer

(2014) Tomas Aparicio et al.   DNA REPAIR

Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae

(2014) L. S. Symington et al.   GENETICS

DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells

(2014) Andreas Sturzenegger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection

(2014) James M. Daley et al.   NUCLEIC ACIDS RESEARCH

Transcription and Recombination: When RNA Meets DNA

(2014) A. Aguilera et al.   Cold Spring Harbor Perspectives in Biology

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

DNA Strand Exchange and RecA Homologs in Meiosis

(2014) M. Scott Brown et al.   Cold Spring Harbor Perspectives in Biology

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

DNA unwinding heterogeneity by RecBCD results from static molecules able to equilibrate

(2013) Bian Liu et al.   NATURE

Nucleosome dynamics regulates DNA processing

(2013) Nicholas L Adkins et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nucleosome Dynamics as Modular Systems that Integrate DNA Damage and Repair

(2013) C. L. Peterson et al.   Cold Spring Harbor Perspectives in Biology

Mutations Arising During Repair of Chromosome Breaks

(2012) Anna Malkova et al.   Annual Review of Genetics

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

(2012) Thomas Costelloe et al.   NATURE

The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends

(2012) Xuefeng Chen et al.   NATURE

Analysis of MRE11's function in the 5'->3' processing of DNA double-strand breaks

(2012) S. Liao et al.   NUCLEIC ACIDS RESEARCH

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

The RecQ DNA Helicases in DNA Repair

(2010) Kara A. Bernstein et al.   Annual Review of Genetics

RecQ family helicases in genome stability: Lessons from gene disruption studies in DT40 cells

(2010) Masayuki Seki et al.   CELL CYCLE

The Full-length Saccharomyces cerevisiae Sgs1 Protein Is a Vigorous DNA Helicase That Preferentially Unwinds Holliday Junctions

(2010) Petr Cejka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

DNA end resection: Many nucleases make light work

(2009) Eleni P. Mimitou et al.   DNA REPAIR

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Chromatin dynamics during repair of chromosomal DNA double-strand breaks

(2009) Manisha Sinha et al.   Epigenomics

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome

(2008) T. R. Singh et al.   GENES & DEVELOPMENT

RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability

(2008) D. Xu et al.   GENES & DEVELOPMENT

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE