Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

DNA stretching induces Cas9 off-target activity

(2019) Matthew D. Newton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules

(2019) Pilar Gutierrez-Escribano et al.   Science Advances

Supercoiling DNA optically

(2019) Graeme A. King et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two distinct conformational states define the interaction of human RAD51‐ATP with single‐stranded DNA

(2018) Ineke Brouwer et al.   EMBO JOURNAL

The Initial Response of a Eukaryotic Replisome to DNA Damage

(2018) Martin R.G. Taylor et al.   MOLECULAR CELL

Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites

(2018) Kalina T Haas et al.   NUCLEIC ACIDS RESEARCH

Fluorogenic RNA Mango aptamers for imaging small non-coding RNAs in mammalian cells

(2018) Alexis Autour et al.   Nature Communications

The ATPase activity of E. coli RecA prevents accumulation of toxic complexes formed by erroneous binding to undamaged double stranded DNA

(2018) Daniil V Gataulin et al.   NUCLEIC ACIDS RESEARCH

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity

(2017) Ci Ji Lim et al.   Nature Communications

Mechanism and regulation of DNA end resection in eukaryotes

(2016) Lorraine S. Symington   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling

(2016) Martin R.G. Taylor et al.   MOLECULAR CELL

Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange

(2016) Jingfei Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange

(2016) Jingfei Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination

(2015) Martin R.G. Taylor et al.   CELL

The auxin-inducible degradation (AID) system enables versatile conditional protein depletion in C. elegans

(2015) L. Zhang et al.   DEVELOPMENT

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

(2015) Weixing Zhao et al.   MOLECULAR CELL

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

(2015) M. Raschle et al.   SCIENCE

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

(2014) Samuel H. Sternberg et al.   NATURE

Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor

(2014) Taha Shahid et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution

(2014) Andrea Candelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A toolbox for generating single-stranded DNA in optical tweezers experiments

(2013) Andrea Candelli et al.   BIOPOLYMERS

BRCA2 is epistatic to the RAD51 paralogs in response to DNA damage

(2013) Ryan B. Jensen et al.   DNA REPAIR

Rad51 Paralog Complexes BCDX2 and CX3 Act at Different Stages in the BRCA1-BRCA2-Dependent Homologous Recombination Pathway

(2012) J. Chun et al.   MOLECULAR AND CELLULAR BIOLOGY

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA

(2012) Jason C. Bell et al.   NATURE

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

(2011) Jie Liu et al.   NATURE

Germline mutations in RAD51D confer susceptibility to ovarian cancer

(2011) Chey Loveday et al.   NATURE GENETICS

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

(2010) Alfons Meindl et al.   NATURE GENETICS

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

(2010) Tina Thorslund et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

(2010) Rémi Buisson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Defective Resection at DNA Double-Strand Breaks Leads to De Novo Telomere Formation and Enhances Gene Targeting

(2010) Woo-Hyun Chung et al.   PLoS Genetics

Visualizing the Disassembly of S. cerevisiae Rad51 Nucleoprotein Filaments

(2009) Ragan B. Robertson et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules

(2009) J. Hilario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

(2008) Joost van Mameren et al.   NATURE