Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration

PLPP/CIN-mediated NF2-serine 10 dephosphorylation regulates F-actin stability and Mdm2 degradation in an activity-dependent manner

(2021) Ji-Eun Kim et al.   Cell Death & Disease

The human O-GlcNAcome database and meta-analysis

(2021) Eugenia Wulff-Fuentes et al.   Scientific Data

O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis

(2021) Jinsu Park et al.   Science Advances

Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks

(2021) Markku Hakala et al.   NATURE CELL BIOLOGY

Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism

(2021) Lisa K. Smith et al.   PLoS One

Redox Regulation of the Actin Cytoskeleton in Cell Migration and Adhesion: On the Way to a Spatiotemporal View

(2021) Emre Balta et al.   Frontiers in Cell and Developmental Biology

Role of Small GTPase RhoA in DNA Damage Response

(2021) Chibin Cheng et al.   Biomolecules

Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease

(2021) Shun-Fat Lau et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cholesterol‐recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: The case of TRKB

(2021) Cecilia Cannarozzo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neddylation is required for presynaptic clustering of mGlu7 and maturation of presynaptic terminals

(2021) Minji Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Pharmacological blockers of CCR5 and CXCR4 improve recovery after traumatic brain injury

(2021) Yael Friedman-Levi et al.   EXPERIMENTAL NEUROLOGY

Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke

(2021) Zhuoran Wang et al.   EXPERIMENTAL NEUROLOGY

Targeting neddylation E2s: a novel therapeutic strategy in cancer

(2021) Yi-Chao Zheng et al.   Journal of Hematology & Oncology

Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function

(2021) Felix Schneider et al.   PROGRESS IN NEUROBIOLOGY

Profilin2 regulates actin rod assembly in neuronal cells

(2021) Lisa Marie Walter et al.   Scientific Reports

Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling

(2021) Junchen Chen et al.   Cell Reports

Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories

(2021) Camille Cuveillier et al.   Frontiers in Molecular Neuroscience

Mitochondrial Dynamics: A Key Role in Neurodegeneration and a Potential Target for Neurodegenerative Disease

(2021) Danying Yang et al.   Frontiers in Neuroscience

Deletion of the Actin-Associated Tropomyosin Tpm3 Leads to Reduced Cell Complexity in Cultured Hippocampal Neurons—New Insights into the Role of the C-Terminal Region of Tpm3.1

(2021) Tamara Tomanić et al.   Cells

Advances in Cancer Treatment by Targeting the Neddylation Pathway

(2021) Wenbin Gai et al.   Frontiers in Cell and Developmental Biology

New Insights into Cellular Functions of Nuclear Actin

(2021) Malgorzata Kloc et al.   Biology-Basel

Putting the axonal periodic scaffold in order

(2021) Christophe Leterrier   CURRENT OPINION IN NEUROBIOLOGY

Interactions of Amyloid-β with Membrane Proteins

(2021) Benita Wiatrak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sleep deprivation reduces the density of individual spine subtypes in a branch‐specific fashion in CA1 neurons

(2021) Youri G. Bolsius et al.   JOURNAL OF SLEEP RESEARCH

Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo

(2021) Souvarish Sarkar et al.   Molecular Neurodegeneration

Reactive Oxygen Species Mediate Activity-Regulated Dendritic Plasticity Through NADPH Oxidase and Aquaporin Regulation

(2021) Serene Dhawan et al.   Frontiers in Cellular Neuroscience

Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene

(2021) Linda S. Forero-Quintero et al.   Nature Communications

Different translation dynamics of β- and γ-actin regulates cell migration

(2021) Pavan Vedula et al.   eLife

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

(2021) François-Xavier Cantrelle et al.   Frontiers in Molecular Neuroscience

Post-translational Modifications of the Protein Termini

(2021) Li Chen et al.   Frontiers in Cell and Developmental Biology

Remodeling of Intracellular Ca2+ Homeostasis in Rat Hippocampal Neurons Aged In Vitro

(2020) Maria Calvo-Rodriguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics

(2020) Annette M. Vogl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CofActor: A light- and stress-gated optogenetic clustering tool to study disease-associated cytoskeletal dynamics in living cells

(2020) Fatema B Salem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamics of actin network turnover is self-organized by a growth-depletion feedback

(2020) P. Bleicher et al.   Scientific Reports

Cofilin dysregulation alters actin turnover in frataxin-deficient neurons

(2020) Diana C. Muñoz-Lasso et al.   Scientific Reports

The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction

(2020) Ana Rita Costa et al.   eLife

Targeting Rho GTPase Signaling Networks in Cancer

(2020) Natasha S. Clayton et al.   Frontiers in Cell and Developmental Biology

Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer’s Disease with APP Osaka Mutation

(2020) Hiroyuki Shimada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion

(2020) Nadia Efimova et al.   JOURNAL OF CELL BIOLOGY

Modifications to cytoskeleton-associated proteins in dendritic spines underlie the adaptive plasticity involved in long term reference memory

(2020) David González-Tapia et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Cofilin Inhibition by Limk1 Reduces Rod Formation and Cell Apoptosis after Ischemic Stroke

(2020) Bin Chen et al.   NEUROSCIENCE

Insights into the evolution of regulated actin dynamics via characterization of primitive gelsolin/cofilin proteins from Asgard archaea

(2020) Caner Akıl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration

(2020) Anjali Bisaria et al.   SCIENCE

Neuronal activity remodels the F-actin based submembrane lattice in dendrites but not axons of hippocampal neurons

(2020) Flavie Lavoie-Cardinal et al.   Scientific Reports

SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation

(2020) Cenxiao Fang et al.   Autophagy

Kill one or kill the many: interplay between mitophagy and apoptosis

(2020) Simone Wanderoy et al.   BIOLOGICAL CHEMISTRY

Postmitotic expansion of cell nuclei requires nuclear actin filament bundling by α‐actinin 4

(2020) Sylvia Krippner et al.   EMBO REPORTS

Subcutaneous Administration of AMD3100 into Mice Models of Alzheimer’s Disease Ameliorated Cognitive Impairment, Reduced Neuroinflammation, and Improved Pathophysiological Markers

(2020) Yuval Gavriel et al.   JOURNAL OF ALZHEIMERS DISEASE

Lysine acetylation of cytoskeletal proteins: Emergence of an actin code

(2020) Mu A et al.   JOURNAL OF CELL BIOLOGY

Profilin’s affinity for formin regulates the availability of filament ends for actin monomer binding

(2020) Mark E. Zweifel et al.   JOURNAL OF MOLECULAR BIOLOGY

Lamin A/C deficiency enables increased myosin-II bipolar filament ensembles that promote divergent actomyosin network anomalies through self-organization

(2020) O’Neil Wiggan et al.   MOLECULAR BIOLOGY OF THE CELL

Acetylation and Deacetylation of DNA Repair Proteins in Cancers

(2020) Shiqin Li et al.   Frontiers in Oncology

Forces to Drive Neuronal Migration Steps

(2020) Takunori Minegishi et al.   Frontiers in Cell and Developmental Biology

Phosphorylation-dependent regulation of SPOP by LIMK2 promotes castration-resistant prostate cancer

(2020) Kumar Nikhil et al.   BRITISH JOURNAL OF CANCER

Twinfilin bypasses assembly conditions and actin filament aging to drive barbed end depolymerization

(2020) Shashank Shekhar et al.   JOURNAL OF CELL BIOLOGY

Chemokine Receptors CC Chemokine Receptor 5 and C-X-C Motif Chemokine Receptor 4 Are New Therapeutic Targets for Brain Recovery after Traumatic Brain Injury

(2020) Sigal Liraz-Zaltsman et al.   JOURNAL OF NEUROTRAUMA

α-Actinin-4 Promotes the Progression of Prostate Cancer Through the Akt/GSK-3β/β-Catenin Signaling Pathway

(2020) Sungyeon Park et al.   Frontiers in Cell and Developmental Biology

Actin dynamics in the growth cone: a key player in axon regeneration

(2020) Sérgio Carvalho Leite et al.   CURRENT OPINION IN NEUROBIOLOGY

CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury

(2019) Mary T. Joy et al.   CELL

Targeting ROCK/LIMK/cofilin signaling pathway in cancer

(2019) Mee-Hyun Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Actin–tropomyosin distribution in non-muscle cells

(2019) Dietmar J. Manstein et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

O-GlcNAcylation of Amyloid-β Protein Precursor by Insulin Signaling Reduces Amyloid-β Production

(2019) Oh Hoon Kwon et al.   JOURNAL OF ALZHEIMERS DISEASE

Actin(g) on mitochondria – a role for cofilin1 in neuronal cell death pathways

(2019) Lena Hoffmann et al.   BIOLOGICAL CHEMISTRY

Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors

(2019) Tak Shun Fung et al.   JOURNAL OF CELL SCIENCE

ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS

(2019) Andrea Tedeschi et al.   NEURON

Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking

(2019) Anna Kruyer et al.   PLoS One

Membrane-associated periodic skeleton is a signaling platform for RTK transactivation in neurons

(2019) Ruobo Zhou et al.   SCIENCE

Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain

(2019) Elizabeth G. Wheatley et al.   CURRENT BIOLOGY

Oligomerization Affects the Ability of Human Cyclase-Associated Proteins 1 and 2 to Promote Actin Severing by Cofilins

(2019) Vedud Purde et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer’s Disease

(2019) David E. Kang et al.   JOURNAL OF ALZHEIMERS DISEASE

Impact of the actin cytoskeleton on cell development and function mediated via tropomyosin isoforms

(2019) Edna C. Hardeman et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics

(2019) Ying Wang et al.   Nature Communications

NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase

(2019) Yung-Lin Hsieh et al.   Cell Reports

Role of ACTN4 in Tumorigenesis, Metastasis, and EMT

(2019) Dmitri Tentler et al.   Cells

Profilin as a dual regulator of actin and microtubule dynamics

(2019) Rita Pinto‐Costa et al.   Cytoskeleton

Profilin2a‐phosphorylation as a regulatory mechanism for actin dynamics

(2019) Lisa Marie Walter et al.   FASEB JOURNAL

Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself

(2019) Mu A et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrastructure of the axonal periodic scaffold reveals a braid-like organization of actin rings

(2019) Stéphane Vassilopoulos et al.   Nature Communications

A new bioluminescence-based tool for modulating target proteins in live cells

(2019) Tetsuya Ishimoto et al.   Scientific Reports

INO80 and SWR1 complexes: the non-identical twins of chromatin remodelling

(2019) Oliver Willhoft et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

SIRT2 reduces actin polymerization and cell migration through deacetylation and degradation of HSP90

(2018) Jung Sun Min et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton

(2018) Joyce C.M. Meiring et al.   CURRENT BIOLOGY

Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation

(2018) Maria Chatzifrangkeskou et al.   HUMAN MOLECULAR GENETICS

Brain ischemic insult induces cofilin rod formation leading to synaptic dysfunction in neurons

(2018) Liang Shu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Species-Specific Functions of Twinfilin in Actin Filament Depolymerization

(2018) Denise M. Hilton et al.   JOURNAL OF MOLECULAR BIOLOGY

α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

(2018) Dalila G. Ordonez et al.   NEURON

Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin

(2018) Hiroaki Mizuno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein

(2018) Michael Schnoor et al.   TRENDS IN CELL BIOLOGY

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model

(2018) Sheng-Jun Fan et al.   Cell Death & Disease

Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation

(2018) Yue Zhang et al.   Cell Death & Disease

Structural basis of actin monomer re-charging by cyclase-associated protein

(2018) Tommi Kotila et al.   Nature Communications

Structural basis for cofilin binding and actin filament disassembly

(2018) Kotaro Tanaka et al.   Nature Communications

Cofilin Rods and Aggregates Concur with Tau Pathology and the Development of Alzheimer's Disease

(2018) Tasnim Rahman et al.   JOURNAL OF ALZHEIMERS DISEASE

Cofilin-actin rod formation in neuronal processes after brain ischemia

(2018) Seok Joon Won et al.   PLoS One

A Serine/Threonine Kinase 16-Based Phospho-Proteomics Screen Identifies WD Repeat Protein-1 As A Regulator Of Constitutive Secretion

(2018) Alfonso López-Coral et al.   Scientific Reports

HIV Associated Neurodegenerative Disorders: A New Perspective on the Role of Lipid Rafts in Gp120-Mediated Neurotoxicity

(2018) Lisa K. Smith et al.   CURRENT HIV RESEARCH

Processive flow by biased polymerization mediates the slow axonal transport of actin

(2018) Nilaj Chakrabarty et al.   JOURNAL OF CELL BIOLOGY

Real-Time Single-Molecule Kinetic Analyses of AIP1-Enhanced Actin Filament Severing in the Presence of Cofilin

(2018) Kimihide Hayakawa et al.   JOURNAL OF MOLECULAR BIOLOGY

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

(2018) Renaud Prudent et al.   PLoS One

Shootin1b Mediates a Mechanical Clutch to Produce Force for Neuronal Migration

(2018) Takunori Minegishi et al.   Cell Reports

Actinin-1 and actinin-4 play essential but distinct roles in invadopodia formation by carcinoma cells

(2017) Hideki Yamaguchi et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease spinal muscular atrophy (SMA)

(2017) Sebastian Rademacher et al.   HUMAN MOLECULAR GENETICS

It takes a village to raise a branch: Cellular mechanisms of the initiation of axon collateral branches

(2017) Lorena Armijo-Weingart et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A transient pool of nuclear F-actin at mitotic exit controls chromatin organization

(2017) Christian Baarlink et al.   NATURE CELL BIOLOGY

Peptide regulation of cofilin activity in the CNS: A novel therapeutic approach for treatment of multiple neurological disorders

(2017) Alisa E. Shaw et al.   PHARMACOLOGY & THERAPEUTICS

Structural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neurons

(2017) Boran Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin Waves Do Not Boost Neurite Outgrowth in the Early Stages of Neuron Maturation

(2017) Simone Mortal et al.   Frontiers in Cellular Neuroscience

Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission

(2017) Katharina Rehklau et al.   Cell Death & Disease

Catastrophic disassembly of actin filaments via Mical-mediated oxidation

(2017) Elena E. Grintsevich et al.   Nature Communications

Actin-Interacting Protein 1 Contributes to Intranuclear Rod Assembly in Dictyostelium discoideum

(2017) Hellen C. Ishikawa-Ankerhold et al.   Scientific Reports

Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module

(2017) O’Neil Wiggan et al.   Scientific Reports

Diverse functions of homologous actin isoforms are defined by their nucleotide, rather than their amino acid sequence

(2017) Pavan Vedula et al.   eLife

The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling Modules

(2017) Rafael Linden   Frontiers in Molecular Neuroscience

Mitochondrial and Oxidative Stress-Mediated Activation of Protein Kinase D1 and Its Importance in Pancreatic Cancer

(2017) Heike Döppler et al.   Frontiers in Oncology

Mapping Cofilin-Actin Rods in Stressed Hippocampal Slices and the Role of cdc42 in Amyloid-β-Induced Rods

(2017) Richard C. Davis et al.   JOURNAL OF ALZHEIMERS DISEASE

Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation

(2017) Tian Liu et al.   Scientific Reports

Maraviroc-intensified combined antiretroviral therapy improves cognition in virally suppressed HIV-associated neurocognitive disorder

(2016) Thomas M. Gates et al.   AIDS

Emerging roles for motor proteins in progenitor cell behavior and neuronal migration during brain development

(2016) Tiago J. Dantas et al.   Cytoskeleton

Partial Amelioration of Synaptic and Cognitive Deficits by Inhibiting Cofilin Dephosphorylation in an Animal Model of Alzheimer’s Disease

(2016) Yulei Deng et al.   JOURNAL OF ALZHEIMERS DISEASE

Nanoscopic compartmentalization of membrane protein motion at the axon initial segment

(2016) David Albrecht et al.   JOURNAL OF CELL BIOLOGY

Cellular functions of the ADF/cofilin family at a glance

(2016) Georgios Kanellos et al.   JOURNAL OF CELL SCIENCE

Regulators of actin filament barbed ends at a glance

(2016) Shashank Shekhar et al.   JOURNAL OF CELL SCIENCE

Actin filaments as dynamic reservoirs for Drp1 recruitment

(2016) Anna L. Hatch et al.   MOLECULAR BIOLOGY OF THE CELL

Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2

(2016) Atul Kumar et al.   Frontiers in Cellular Neuroscience

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

(2016) Andrew S. Moore et al.   Nature Communications

Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation

(2016) Amy M Winans et al.   eLife

Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1

(2016) Robbert Havekes et al.   eLife

Erratum: Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers

(2015) J A Woo et al.   CELL DEATH AND DIFFERENTIATION

Regulation of ECM degradation and axon guidance by growth cone invadosomes

(2015) M. Santiago-Medina et al.   DEVELOPMENT

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Cytokine-induced macropinocytosis in macrophages is regulated by 14-3-3ζ through its interaction with serine-phosphorylated coronin 1

(2015) Somdeb BoseDasgupta et al.   FEBS Journal

The Actin Depolymerizing Factor (ADF)/Cofilin Signaling Pathway and DNA Damage Responses in Cancer

(2015) Chun-Yuan Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility

(2015) Michael Howell et al.   JOURNAL OF CELL BIOLOGY

Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators

(2015) J. Dopie et al.   JOURNAL OF CELL SCIENCE

Cofilin-2 Phosphorylation and Sequestration in Myocardial Aggregates

(2015) Khaushik Subramanian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition

(2015) Annette M Vogl et al.   NATURE NEUROSCIENCE

Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels

(2015) Violaine Delorme-Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connecting the dots between tau dysfunction and neurodegeneration

(2015) Bess Frost et al.   TRENDS IN CELL BIOLOGY

RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction

(2015) J A Woo et al.   Cell Death & Disease

HDAC6 and RhoA are novel players in Abeta-driven disruption of neuronal polarity

(2015) Hanako Tsushima et al.   Nature Communications

Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity

(2015) Joju George et al.   eLife

ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and Exocytosis

(2014) Michael Wolf et al.   CEREBRAL CORTEX

Taurine chloramine-induced inactivation of cofilin protein through methionine oxidation

(2014) Shen Luo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

Structure and Mechanism of Mouse Cyclase-associated Protein (CAP1) in Regulating Actin Dynamics

(2014) Silvia Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A systematic nomenclature for mammalian tropomyosin isoforms

(2014) Michael A. Geeves et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Cofilin Inhibition Restores Neuronal Cell Death in Oxygen–Glucose Deprivation Model of Ischemia

(2014) Anusha Madineni et al.   MOLECULAR NEUROBIOLOGY

The neurobiological basis of cognitive impairment in Parkinson's disease

(2014) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Cryo-EM reveals different coronin binding modes for ADP– and ADP–BeFx actin filaments

(2014) Peng Ge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea

(2014) Sharolyn V. Kawakami-Schulz et al.   PHYSIOLOGICAL GENOMICS

A Genetically Encoded Reporter for Real-Time Imaging of Cofilin-Actin Rods in Living Neurons

(2014) Jianjie Mi et al.   PLoS One

Amyloid-β and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons

(2014) Keifer P. Walsh et al.   PLoS One

Protein Kinase D Isoforms Differentially Modulate Cofilin-Driven Directed Cell Migration

(2014) Heike Döppler et al.   PLoS One

Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin

(2014) J. D. Winkelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase D-mediated phosphorylation at Ser99regulates localization of p21-activated kinase 4

(2013) Ligia I. Bastea et al.   BIOCHEMICAL JOURNAL

Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells

(2013) Lubna H Tahtamouni et al.   BMC CELL BIOLOGY

Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target

(2013) Mads Gabrielsen et al.   Cell Communication and Signaling

GMF Severs Actin-Arp2/3 Complex Branch Junctions by a Cofilin-like Mechanism

(2013) Casey A. Ydenberg et al.   CURRENT BIOLOGY

O-GlcNAcylation of Cofilin Promotes Breast Cancer Cell Invasion

(2013) Xun Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronophin Dimerization Is Required for Proper Positioning of Its Substrate Specificity Loop

(2013) Christian Kestler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of cofilin-actin rods following cucurbitacin-B-induced actin aggregation depends on slingshot homolog 1-mediated cofilin hyperactivation

(2013) Yan-Ting Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Actin Polymerization Negatively Regulates p53 Function by Impairing Its Nuclear Import in Response to DNA Damage

(2013) Ling Wang et al.   PLoS One

Promiscuous Alzheimer's Amyloid: Yet Another Partner

(2013) I. Benilova et al.   SCIENCE

Molecular Cooperativity of Drebrin1-300 Binding and Structural Remodeling of F-Actin

(2012) Shivani Sharma et al.   BIOPHYSICAL JOURNAL

Both NMDA and non-NMDA receptors mediate glutamate stimulation induced cofilin rod formation in cultured hippocampal neurons

(2012) Ben Chen et al.   BRAIN RESEARCH

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation

(2012) Kensaku Mizuno   CELLULAR SIGNALLING

Septin-Driven Coordination of Actin and Microtubule Remodeling Regulates the Collateral Branching of Axons

(2012) Jianli Hu et al.   CURRENT BIOLOGY

Post-translational modification and regulation of actin

(2012) Jonathan R Terman et al.   CURRENT OPINION IN CELL BIOLOGY

ADF/Cofilin Regulates Actomyosin Assembly through Competitive Inhibition of Myosin II Binding to F-Actin

(2012) O'Neil Wiggan et al.   DEVELOPMENTAL CELL

Cofilin nuclear–cytoplasmic shuttling affects cofilin–actin rod formation during stress

(2012) Lise Nicole Munsie et al.   JOURNAL OF CELL SCIENCE

LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy

(2012) E. O. Johnson et al.   JOURNAL OF CELL SCIENCE

Incorporation of Cofilin into Rods Depends on Disulfide Intermolecular Bonds: Implications for Actin Regulation and Neurodegenerative Disease

(2012) B. W. Bernstein et al.   JOURNAL OF NEUROSCIENCE

Nerve Growth Factor-Induced Formation of Axonal Filopodia and Collateral Branches Involves the Intra-Axonal Synthesis of Regulators of the Actin-Nucleating Arp2/3 Complex

(2012) M. Spillane et al.   JOURNAL OF NEUROSCIENCE

Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release

(2012) Megumi Sakuma et al.   MOLECULAR BIOLOGY OF THE CELL

Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin

(2012) Faisal Chaudhry et al.   MOLECULAR BIOLOGY OF THE CELL

ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain

(2012) Kevin C. Flynn et al.   NEURON

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

Active maintenance of nuclear actin by importin 9 supports transcription

(2012) J. Dopie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

(2012) K. Xu et al.   SCIENCE

How cholesterol regulates endothelial biomechanics

(2012) Zhongkui Hong et al.   Frontiers in Physiology

A Molecular Pathway for Myosin II Recruitment to Stress Fibers

(2011) Sari Tojkander et al.   CURRENT BIOLOGY

Actin Depolymerization-Based Force Retracts the Cell Rear in Polarizing and Migrating Cells

(2011) Tayamika Mseka et al.   CURRENT BIOLOGY

Cofilin Tunes the Nucleotide State of Actin Filaments and Severs at Bare and Decorated Segment Boundaries

(2011) Cristian Suarez et al.   CURRENT BIOLOGY

Actin-depolymerizing factor homology domain: A conserved fold performing diverse roles in cytoskeletal dynamics

(2011) Minna Poukkula et al.   Cytoskeleton

NADPH-oxidase activation and cognition in Alzheimer disease progression

(2011) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease

(2011) Lise Munsie et al.   HUMAN MOLECULAR GENETICS

Protein Kinase D Regulates Cofilin Activity through p21-activated Kinase 4

(2011) Samantha J. Spratley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cofilin Aggregation Blocks Intracellular Trafficking and Induces Synaptic Loss in Hippocampal Neurons

(2011) Joseph Cichon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cofilin activation mediates Bax translocation to mitochondria during excitotoxic neuronal death

(2011) Inmaculada Posadas et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation

(2011) Richard C Davis et al.   Molecular Neurodegeneration

Rapid Changes in Phospho-MAP/Tau Epitopes during Neuronal Stress: Cofilin-Actin Rods Primarily Recruit Microtubule Binding Domain Epitopes

(2011) Ineka T. Whiteman et al.   PLoS One

Direct Redox Regulation of F-Actin Assembly and Disassembly by Mical

(2011) R.-J. Hung et al.   SCIENCE

Unraveling the enigma: progress towards understanding the coronin family of actin regulators

(2011) Keefe T. Chan et al.   TRENDS IN CELL BIOLOGY

Filopodia initiation

(2011) Changsong Yang et al.   Cell Adhesion & Migration

Signal transduction in neurons: effects of cellular prion protein on fyn kinase and ERK1/2 kinase

(2011) Vittorio Tomasi   Immunity & Ageing

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

GMF is an evolutionarily developed Adf/cofilin-super family protein involved in the Arp2/3 complex-mediated organization of the actin cytoskeleton

(2010) Kentaro Nakano et al.   Cytoskeleton

Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1

(2010) Bonnie M. Marsick et al.   Developmental Neurobiology

Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics

(2010) Marco B Rust et al.   EMBO JOURNAL

A Pathogenic Relationship Between a Regulator of the Actin Cytoskeleton and Serum Response Factor

(2010) Angela M. Verdoni et al.   GENETICS

The Actin-binding Protein, Actinin Alpha 4 (ACTN4), Is a Nuclear Receptor Coactivator that Promotes Proliferation of MCF-7 Breast Cancer Cells

(2010) Simran Khurana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Mical links semaphorins to F-actin disassembly

(2010) Ruei-Jiun Hung et al.   NATURE

ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity

(2010) Jiaping Gu et al.   NATURE NEUROSCIENCE

ADF/Cofilin: a functional node in cell biology

(2010) Barbara W. Bernstein et al.   TRENDS IN CELL BIOLOGY

Growth cone-like waves transport actin and promote axonogenesis and neurite branching

(2009) Kevin C. Flynn et al.   Developmental Neurobiology

Isolation and Characterization of Cytoplasmic Cofilin-Actin Rods

(2009) Laurie S. Minamide et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis

(2009) H. Takahashi et al.   JOURNAL OF CELL SCIENCE

Activated Actin-Depolymerizing Factor/Cofilin Sequesters Phosphorylated Microtubule-Associated Protein during the Assembly of Alzheimer-Like Neuritic Cytoskeletal Striations

(2009) I. T. Whiteman et al.   JOURNAL OF NEUROSCIENCE

Reactive Oxygen Species Regulate a Slingshot-Cofilin Activation Pathway

(2009) Jun-Sub Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Coronin Switches Roles in Actin Disassembly Depending on the Nucleotide State of Actin

(2009) Meghal Gandhi et al.   MOLECULAR CELL

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin

(2009) Fábio Klamt et al.   NATURE CELL BIOLOGY

Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin–proteasome pathway

(2009) Y Yoo et al.   ONCOGENE

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Chronophin Mediates an ATP-Sensing Mechanism for Cofilin Dephosphorylation and Neuronal Cofilin-Actin Rod Formation

(2008) Timothy Y. Huang et al.   DEVELOPMENTAL CELL

Mitochondrial shuttling of CAP1 promotes actin- and cofilin-dependent apoptosis

(2008) C. Wang et al.   JOURNAL OF CELL SCIENCE

Essential Phosphatases and a Phospho-Degron Are Critical for Regulation of SRC-3/AIB1 Coactivator Function and Turnover

(2008) Chao Li et al.   MOLECULAR CELL

Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis

(2008) Sara Geraldo et al.   NATURE CELL BIOLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Effect of destrin mutations on the gene expression profile in vivo

(2008) Angela M. Verdoni et al.   PHYSIOLOGICAL GENOMICS