Mitochondrial and Oxidative Stress-Mediated Activation of Protein Kinase D1 and Its Importance in Pancreatic Cancer

Targeting reactive oxygen species in development and progression of pancreatic cancer

(2016) Nisha Durand et al.   Expert Review of Anticancer Therapy

HSP27 Knockdown Increases Cytoplasmic p21 and Cisplatin Sensitivity in Ovarian Carcinoma Cells

(2016) Hao Lu et al.   ONCOLOGY RESEARCH

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

(2016) Geou-Yarh Liou et al.   Cell Reports

PKD1 Protein Is Involved in Reactive Oxygen Species-mediated Mitochondrial Depolarization in Cooperation with Protein Kinase Cδ (PKCδ)

(2015) Thianzhou Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular cloning, epigenetic regulation, and functional characterization ofPrkd1gene promoter in dopaminergic cell culture models of Parkinson's disease

(2015) Muhammet Ay et al.   JOURNAL OF NEUROCHEMISTRY

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

(2015) Geou-Yarh Liou et al.   Nature Communications

Mechanisms for redox-regulation of protein kinase C

(2015) Susan F. Steinberg   Frontiers in Pharmacology

Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing

(2014) J H Song et al.   ONCOGENE

Protein Kinase D1 (PKD1) Phosphorylation Promotes Dopaminergic Neuronal Survival during 6-OHDA-Induced Oxidative Stress

(2014) Arunkumar Asaithambi et al.   PLoS One

Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation

(2014) P. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Stress Induced by Inactivation of TP53INP1 Cooperates with KrasG12D to Initiate and Promote Pancreatic Carcinogenesis in the Murine Pancreas

(2013) Talal Al Saati et al.   AMERICAN JOURNAL OF PATHOLOGY

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Oncogenic K-Ras requires activation for enhanced activity

(2013) H Huang et al.   ONCOGENE

Antioxidant Status and Oxidative Stress Markers in Pancreatic Cancer and Chronic Pancreatitis

(2013) Jana Kodydkova et al.   PANCREAS

PLC , PKD1, and SSH1L Transduce RhoA Signaling to Protect Mitochondria from Oxidative Stress in the Heart

(2013) S. Y. Xiang et al.   Science Signaling

Heat Shock Proteins in the Brain: Role of Hsp70, Hsp 27, and HO-1 (Hsp32) and Their Therapeutic Potential

(2013) Frank R Sharp et al.   Translational Stroke Research

EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

(2012) Carolina Navas et al.   CANCER CELL

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Role of heat shock protein 27 in gemcitabine-resistant human pancreatic cancer: Comparative proteomic analyses

(2012) QING-HUA LIU et al.   Molecular Medicine Reports

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

(2011) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

(2011) Yumin Hu et al.   CELL RESEARCH

Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology

(2011) Ya Fu et al.   EMBO REPORTS

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Protein Kinase D Signaling: Multiple Biological Functions in Health and Disease

(2011) Enrique Rozengurt   PHYSIOLOGY

A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis in isolated rat acini

(2010) Edwin C. Thrower et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

(2010) K. B. Harikumar et al.   MOLECULAR CANCER THERAPEUTICS

Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes

(2010) S N Arun et al.   ONCOGENE

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling

(2009) C. F. Cowell et al.   JOURNAL OF CELL SCIENCE

Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot

(2009) Tim Eiseler et al.   NATURE CELL BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Protein kinase D1 mediates NF-κB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells

(2008) Jingzhen Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

PKD prevents H2O2-induced apoptosis via NF-κB and p38 MAPK in RIE-1 cells

(2008) Jun Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS