Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism

CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility

(2020) Lindsay K Festa et al.   eLife

The role of NADPH oxidases in neuronal development

(2020) Aslihan Terzi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Subcutaneous Administration of AMD3100 into Mice Models of Alzheimer’s Disease Ameliorated Cognitive Impairment, Reduced Neuroinflammation, and Improved Pathophysiological Markers

(2020) Yuval Gavriel et al.   JOURNAL OF ALZHEIMERS DISEASE

Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels

(2020) Cristina Sanfilippo et al.   BRAIN RESEARCH

Anti-PrPC antibody rescues cognition and synapses in transgenic alzheimer mice

(2019) Timothy O. Cox et al.   Annals of Clinical and Translational Neurology

HIV-associated neurodegeneration: exploitation of the neuronal cytoskeleton

(2019) Erin D. Wenzel et al.   JOURNAL OF NEUROVIROLOGY

CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury

(2019) Mary T. Joy et al.   CELL

Helix-A peptide prevents gp120-mediated neuronal loss

(2019) Valeria Avdoshina et al.   Molecular Brain

Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120

(2019) Erin D. Wenzel et al.   Cell Death & Disease

Entanglement of CCR5 and Alzheimer’s Disease

(2019) Tianwen Li et al.   Frontiers in Aging Neuroscience

Oligomerization Affects the Ability of Human Cyclase-Associated Proteins 1 and 2 to Promote Actin Severing by Cofilins

(2019) Vedud Purde et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Actin dynamics in host-pathogen interaction

(2018) Theresia E. B. Stradal et al.   FEBS LETTERS

Brain ischemic insult induces cofilin rod formation leading to synaptic dysfunction in neurons

(2018) Liang Shu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders

(2018) Coral M. Capó-Vélez et al.   Scientific Reports

Cofilin Rods and Aggregates Concur with Tau Pathology and the Development of Alzheimer's Disease

(2018) Tasnim Rahman et al.   JOURNAL OF ALZHEIMERS DISEASE

Cofilin-actin rod formation in neuronal processes after brain ischemia

(2018) Seok Joon Won et al.   PLoS One

HIV Associated Neurodegenerative Disorders: A New Perspective on the Role of Lipid Rafts in Gp120-Mediated Neurotoxicity

(2018) Lisa K. Smith et al.   CURRENT HIV RESEARCH

HIV-1 Envelope Glycoproteins Induce the Production of TNF-α and IL-10 in Human Monocytes by Activating Calcium Pathway

(2018) Rémi Planès et al.   Scientific Reports

The viral protein gp120 decreases the acetylation of neuronal tubulin: potential mechanism of neurotoxicity

(2017) Valeria Avdoshina et al.   JOURNAL OF NEUROCHEMISTRY

Modulation of Chemokine Receptor Function by Cholesterol: New Prospects for Pharmacological Intervention

(2017) Daniel F. Legler et al.   MOLECULAR PHARMACOLOGY

Peptide regulation of cofilin activity in the CNS: A novel therapeutic approach for treatment of multiple neurological disorders

(2017) Alisa E. Shaw et al.   PHARMACOLOGY & THERAPEUTICS

Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module

(2017) O’Neil Wiggan et al.   Scientific Reports

Actin dynamics and cofilin-actin rods in alzheimer disease

(2016) James R. Bamburg et al.   Cytoskeleton

Immunohistochemistry for the detection of neural and inflammatory cells in equine brain tissue

(2016) Gretchen H. Delcambre et al.   PeerJ

Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers

(2015) J A Woo et al.   CELL DEATH AND DIFFERENTIATION

ADF/cofilin: a crucial regulator of synapse physiology and behavior

(2015) Marco B. Rust   CELLULAR AND MOLECULAR LIFE SCIENCES

Induction of Interleukin-1  by Human Immunodeficiency Virus-1 Viral Proteins Leads to Increased Levels of Neuronal Ferritin Heavy Chain, Synaptic Injury, and Deficits in Flexible Attention

(2015) L. Festa et al.   JOURNAL OF NEUROSCIENCE

RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction

(2015) J A Woo et al.   Cell Death & Disease

A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies

(2015) Mary E. Irwin et al.   Oncotarget

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Evidence for cFMS signaling in HIV production by brain macrophages and microglia

(2014) Lindsey Gerngross et al.   JOURNAL OF NEUROVIROLOGY

A Genetically Encoded Reporter for Real-Time Imaging of Cofilin-Actin Rods in Living Neurons

(2014) Jianjie Mi et al.   PLoS One

Role of Lipid Rafts and GM1 in the Segregation and Processing of Prion Protein

(2014) Laura Botto et al.   PLoS One

Amyloid-β and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons

(2014) Keifer P. Walsh et al.   PLoS One

Viral exploitation of actin: force-generation and scaffolding functions in viral infection

(2014) Mark Spear et al.   VIROLOGICA SINICA

PrP octarepeats region determined the interaction with caveolin-1 and phosphorylation of caveolin-1 and Fyn

(2013) Qi Shi et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Lipid Rafts in Neurodegeneration and Neuroprotection

(2013) Sandro Sonnino et al.   MOLECULAR NEUROBIOLOGY

Curcumin Protects Microglia and Primary Rat Cortical Neurons against HIV-1 gp120-Mediated Inflammation and Apoptosis

(2013) Luyan Guo et al.   PLoS One

Putative cholesterol-binding sites in human immunodeficiency virus (HIV) coreceptors CXCR4 and CCR5

(2013) Mikhail A. Zhukovsky et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

HIV: Cell Binding and Entry

(2013) C. B. Wilen et al.   Cold Spring Harbor Perspectives in Medicine

How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

(2013) Jacques Fantini et al.   Frontiers in Physiology

Both NMDA and non-NMDA receptors mediate glutamate stimulation induced cofilin rod formation in cultured hippocampal neurons

(2012) Ben Chen et al.   BRAIN RESEARCH

Incorporation of Cofilin into Rods Depends on Disulfide Intermolecular Bonds: Implications for Actin Regulation and Neurodegenerative Disease

(2012) B. W. Bernstein et al.   JOURNAL OF NEUROSCIENCE

The chemokine CXCL12 and the HIV-1 envelope protein gp120 regulate spontaneous activity of Cajal-Retzius cells in opposite directions

(2012) Ivan Marchionni et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lipid Raft Redox Signaling: Molecular Mechanisms in Health and Disease

(2011) Si Jin et al.   ANTIOXIDANTS & REDOX SIGNALING

Up-regulation of the Neuronal Nicotinic Receptor α7 by HIV Glycoprotein 120

(2011) Leomar Y. Ballester et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cofilin Aggregation Blocks Intracellular Trafficking and Induces Synaptic Loss in Hippocampal Neurons

(2011) Joseph Cichon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-κB pathway and can be silenced by gp120-specific siRNA

(2011) Ankit Shah et al.   Journal of Neuroinflammation

The Human Immunodeficiency Virus Coat Protein gp120 Promotes Forward Trafficking and Surface Clustering of NMDA Receptors in Membrane Microdomains

(2011) H. Xu et al.   JOURNAL OF NEUROSCIENCE

Neutral sphingomyelinase activation precedes NADPH oxidase-dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor-α

(2011) Brian M. Barth et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Regulation of P-glycoprotein by human immunodeficiency virus-1 in primary cultures of human fetal astrocytes

(2011) Tamima Ashraf et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation

(2011) Richard C Davis et al.   Molecular Neurodegeneration

Subversion of the actin cytoskeleton during viral infection

(2011) Matthew P. Taylor et al.   NATURE REVIEWS MICROBIOLOGY

Neurotoxicity of Human Immunodeficiency Virus-1: Viral Proteins and Axonal Transport

(2011) Italo Mocchetti et al.   NEUROTOXICITY RESEARCH

Lipid rafts: Keys to neurodegeneration

(2010) Cara-Lynne Schengrund   BRAIN RESEARCH BULLETIN

Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics

(2010) Marco B Rust et al.   EMBO JOURNAL

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity

(2010) Jiaping Gu et al.   NATURE NEUROSCIENCE

The chemokine receptor CCR5 in the central nervous system

(2010) Silvia Sorce et al.   PROGRESS IN NEUROBIOLOGY

Isolation and Characterization of Cytoplasmic Cofilin-Actin Rods

(2009) Laurie S. Minamide et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species Regulate a Slingshot-Cofilin Activation Pathway

(2009) Jun-Sub Kim et al.   MOLECULAR BIOLOGY OF THE CELL

HIV Envelope-CXCR4 Signaling Activates Cofilin to Overcome Cortical Actin Restriction in Resting CD4 T Cells

(2008) Alyson Yoder et al.   CELL

Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study

(2008) Yuntao Wu et al.   Retrovirology