The Actin Depolymerizing Factor (ADF)/Cofilin Signaling Pathway and DNA Damage Responses in Cancer

Chemotherapy in vivo against M109 murine lung carcinoma with cytochalasin B by localized, systemic, and liposomal administration

(2015) Matthew Trendowski et al.   INVESTIGATIONAL NEW DRUGS

Neuronal maturation and laminar formation in the chicken optic tectum are accompanied by the transition of phosphorylated cofilin from cytoplasm to nucleus

(2014) Lingling Li et al.   GENE EXPRESSION PATTERNS

A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy

(2014) C. Liu et al.   NUCLEIC ACIDS RESEARCH

Single-molecule imaging and kinetic analysis of cooperative cofilin–actin filament interactions

(2014) Kimihide Hayakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

Polycomb repressive complex 2 contributes to DNA double-strand break repair

(2013) Stuart Campbell et al.   CELL CYCLE

Biophysics of actin filament severing by cofilin

(2013) W. Austin Elam et al.   FEBS LETTERS

Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity

(2013) Jyh-Der Leu et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Molecular Origins of Cofilin-Linked Changes in Actin Filament Mechanics

(2013) Jun Fan et al.   JOURNAL OF MOLECULAR BIOLOGY

Push back to respond better: regulatory inhibition of the DNA double-strand break response

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functions of cofilin in cell locomotion and invasion

(2013) Jose Javier Bravo-Cordero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytochalasin B induces apoptosis through the mitochondrial apoptotic pathway in HeLa human cervical carcinoma cells

(2013) JIYOUNG HWANG et al.   ONCOLOGY REPORTS

Actin Polymerization Negatively Regulates p53 Function by Impairing Its Nuclear Import in Response to DNA Damage

(2013) Ling Wang et al.   PLoS One

Mechanisms of nuclear actin in chromatin-remodeling complexes

(2013) Prabodh Kapoor et al.   TRENDS IN CELL BIOLOGY

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Over-Expression of Cofilin-1 and Phosphoglycerate Kinase 1 in Astrocytomas Involved in Pathogenesis of Radioresistance

(2012) Hua Yan et al.   CNS Neuroscience & Therapeutics

Rad50 Zinc Hook Is Important for the Mre11 Complex to Bind Chromosomal DNA Double-stranded Breaks and Initiate Various DNA Damage Responses

(2012) Jing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cofilin nuclear–cytoplasmic shuttling affects cofilin–actin rod formation during stress

(2012) Lise Nicole Munsie et al.   JOURNAL OF CELL SCIENCE

Actin nucleators in the nucleus: an emerging theme

(2012) L. Weston et al.   JOURNAL OF CELL SCIENCE

Actin realignment and cofilin regulation are essential for barrier integrity during shear stress

(2012) Joshua B. Slee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY

(2012) J. Bradley Zuchero et al.   MOLECULAR BIOLOGY OF THE CELL

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography

(2012) Larry H. Thompson   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE2-Mediated Inhibition of Phagocytosis of Fungi

(2012) C. H. Serezani et al.   Science Signaling

A requirement for polymerized actin in DNA double-strand break repair

(2012) Christi Andrin et al.   Nucleus

Regulated expression of cofilin and the consequent regulation of p27kip1 are essential for G1 phase progression

(2011) Cheng-Han Tsai et al.   CELL CYCLE

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control

(2011) Magtouf Gatei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl

(2011) Zhihua Jiang et al.   Molecular Cancer

DNA damage and autophagy

(2011) Humberto Rodriguez-Rocha et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

BMS-690514, a VEGFR and EGFR tyrosine kinase inhibitor, shows anti-tumoural activity on non-small-cell lung cancer xenografts and induces sequence-dependent synergistic effect with radiation

(2010) Y Loriot et al.   BRITISH JOURNAL OF CANCER

Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair

(2010) Aneliya Velkova et al.   CELL CYCLE

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

(2010) Daniel R Croft et al.   CELL RESEARCH

ADF/Cofilin-Actin Rods in Neurodegenerative Diseases

(2010) J.R. Bamburg et al.   Current Alzheimer Research

Histone Post-Translational Modifications in DNA Damage Response

(2010) L. Méndez-Acuña et al.   CYTOGENETIC AND GENOME RESEARCH

Biological activities of thymosin β4 defined by active sites in short peptide sequences

(2010) Gabriel Sosne et al.   FASEB JOURNAL

The MRN complex in double-strand break repair and telomere maintenance

(2010) Brandon J. Lamarche et al.   FEBS LETTERS

Loss of Aip1 reveals a role in maintaining the actin monomer pool and an in vivo oligomer assembly pathway

(2010) Voytek Okreglak et al.   JOURNAL OF CELL BIOLOGY

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

(2010) Godelieve Smeenk et al.   JOURNAL OF CELL BIOLOGY

Histone H1 Poly[ADP]-Ribosylation Regulates the Chromatin Alterations Required for Learning Consolidation

(2010) A. Fontan-Lozano et al.   JOURNAL OF NEUROSCIENCE

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control

(2010) F-F Hsu et al.   ONCOGENE

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

(2010) A. Bensimon et al.   Science Signaling

The Cytoskeleton Protein Filamin-A Is Required for an Efficient Recombinational DNA Double Strand Break Repair

(2009) J. Yue et al.   CANCER RESEARCH

Immunotherapy of cancer

(2009) Hossein Borghaei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability

(2009) R. M. Densham et al.   MOLECULAR AND CELLULAR BIOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

(2009) Anyong Xie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

(2009) A. J. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE

Ins and outs of ADF/cofilin activity and regulation

(2008) M VANTROYS et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The human actin-related protein hArp5: Nucleo-cytoplasmic shuttling and involvement in DNA repair

(2008) Kumiko Kitayama et al.   EXPERIMENTAL CELL RESEARCH

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

(2008) Longchuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ACTIN DEPOLYMERIZING FACTOR9 controls development and gene expression in Arabidopsis

(2008) Brunilís Burgos-Rivera et al.   PLANT MOLECULAR BIOLOGY

A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a Key Effector in the Response to DNA Damage

(2008) Lina Guerra et al.   PLoS One