NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

(2021) Suowen Xu et al.   PHARMACOLOGICAL REVIEWS

Role of the Nucleotide-Binding Domain-Like Receptor Protein 3 Inflammasome in the Endothelial Dysfunction of Early Sepsis

(2020) Minghao Luo et al.   INFLAMMATION

NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture

(2020) Denise C. Cornelius et al.   PLoS One

The NLRP3 Inflammasome Role in the Pathogenesis of Pregnancy Induced Hypertension and Preeclampsia

(2020) Maciej W. Socha et al.   Cells

Preeclampsia—Pathophysiology and Clinical Presentations

(2020) Christopher W. Ives et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Preeclampsia

(2019) Sarosh Rana et al.   CIRCULATION RESEARCH

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

(2019) Ram Kuwar et al.   Journal of Neuroinflammation

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pre-eclampsia: pathophysiology and clinical implications

(2019) Graham J Burton et al.   BMJ-British Medical Journal

Development of the human placenta

(2019) Margherita Y. Turco et al.   DEVELOPMENT

Inflammasomes: Their Role in Normal and Complicated Pregnancies

(2019) Nardhy Gomez-Lopez et al.   JOURNAL OF IMMUNOLOGY

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors

(2019) Shi-Bin Cheng et al.   Cell Death & Disease

NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus

(2019) Nathanne Santos Ferreira et al.   Cells

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

The NLRP3 rs10754558 polymorphism is a risk factor for preeclampsia in a Chinese Han population

(2018) Longqiang Xu et al.   Journal of Maternal-Fetal & Neonatal Medicine

Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

(2018) Jacob Fulp et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

(2018) Carlo Marchetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts

(2017) Kazuhiro Tamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Advanced glycation end products regulate interleukin-1β production in human placenta

(2017) Kotomi SENO et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia

(2017) Ingrid C.Weel et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The NLRP3 inflammasome in acute myocardial infarction

(2017) Stefano Toldo et al.   Nature Reviews Cardiology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oridonin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-induced RAW264.7 cells and acute lung injury

(2017) Gan Zhao et al.   Oncotarget

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

(2016) Michael J. Primiano et al.   JOURNAL OF IMMUNOLOGY

Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1–Dependent Pathway: Implications for Fetal Growth Restriction

(2016) Marie-Eve Brien et al.   JOURNAL OF IMMUNOLOGY

Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction

(2016) Yang Chen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Pre-eclampsia

(2016) Ben W J Mol et al.   LANCET

SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells

(2016) Yanxiang Li et al.   MOLECULAR IMMUNOLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Caveolae: A Role in Endothelial Inflammation and Mechanotransduction?

(2016) Waled A. Shihata et al.   Frontiers in Physiology

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Coronary Endothelial Dysfunction Induced by Nucleotide Oligomerization Domain-Like Receptor Protein with Pyrin Domain Containing 3 Inflammasome Activation During Hypercholesterolemia: Beyond Inflammation

(2015) Yang Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia

(2015) Dania A. Shah et al.   BIOCHEMICAL PHARMACOLOGY

Serum levels of endocan correlate with the presence and severity of pre-eclampsia

(2015) Muzaffer Cakmak et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Severe preeclampsia: Association of genes polymorphisms and maternal cytokines production in Brazilian population

(2015) Melina B. Pinheiro et al.   CYTOKINE

NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy

(2015) Koumei Shirasuna et al.   ENDOCRINOLOGY

Pregnancy-Induced hypertension

(2015) Evangelia Kintiraki et al.   Hormones-International Journal of Endocrinology and Metabolism

Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse

(2015) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1

(2015) Yang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Tranilast: A review of its therapeutic applications

(2015) Sara Darakhshan et al.   PHARMACOLOGICAL RESEARCH

Molecular mechanisms of maternal vascular dysfunction in preeclampsia

(2015) Styliani Goulopoulou et al.   TRENDS IN MOLECULAR MEDICINE

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Endogenous and Uric Acid-Induced Activation of NLRP3 Inflammasome in Pregnant Women with Preeclampsia

(2015) Mariana Leticia Matias et al.   PLoS One

NLRP1L155H Polymorphism is a Risk Factor for Preeclampsia Development

(2014) Alessandra Pontillo et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Endothelial dysfunction

(2014) Zhen Chen et al.   CURRENT OPINION IN LIPIDOLOGY

How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1

(2014) Peter A. Keyel   CYTOKINE

Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells

(2014) Liang-Mou Kuo et al.   MOLECULES

Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC

(2014) Koumei Shirasuna et al.   Nanotoxicology

The classification, diagnosis and management of the hypertensive disorders of pregnancy: A revised statement from the ISSHP

(2014) A.L. Tranquilli et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome

(2013) Wen Liu et al.   BIOCHEMICAL PHARMACOLOGY

A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse

(2013) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Vascular Dysfunction in Preeclampsia

(2013) Lesley J. Brennan et al.   MICROCIRCULATION

Identification of interleukin-1 beta, but no other inflammatory proteins, as an early onset pre-eclampsia biomarker in first trimester serum by bead-based multiplexed immunoassays

(2013) Jacqueline E. Siljee et al.   PRENATAL DIAGNOSIS

Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer

(2013) A D'Anneo et al.   Cell Death & Disease

The elevation in circulating anti-angiogenic factors is independent of markers of neutrophil activation in preeclampsia

(2012) Wenda Ramma et al.   ANGIOGENESIS

Uric Acid Induces Trophoblast IL-1β Production Via the Inflammasome: Implications for the Pathogenesis of Preeclampsia

(2011) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Monocytic microparticles activate endothelial cells in an IL-1 -dependent manner

(2011) J.-G. Wang et al.   BLOOD

Mechanisms and Potential Therapies for Preeclampsia

(2011) Eric M. George et al.   CURRENT HYPERTENSION REPORTS

Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1

(2011) M. Maroso et al.   JOURNAL OF INTERNAL MEDICINE

Measurement of spiral artery jets: general principles and differences observed in small-for-gestational-age pregnancies

(2011) S. L. Collins et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia

(2010) F Xie et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Randomized controlled trial design in rheumatoid arthritis: the past decade

(2009) Vibeke Strand et al.   ARTHRITIS RESEARCH & THERAPY

A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate

(2008) Roberto Romero et al.   Journal of Maternal-Fetal & Neonatal Medicine