Pyroptosis: Mechanisms and Links with Fibrosis

GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy

(2021) Yinshuang Li et al.   CELL DEATH AND DIFFERENTIATION

Myeloid Ikaros–SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver

(2021) Kentaro Kadono et al.   JOURNAL OF HEPATOLOGY

Programming inflammatory cell death for therapy

(2021) Shelbi Christgen et al.   PHARMACOLOGY & THERAPEUTICS

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Gasdermins deliver a deadly punch to cancer

(2020) Cheng Shen et al.   CELL RESEARCH

Lytic cell death in metabolic liver disease

(2020) Jérémie Gautheron et al.   JOURNAL OF HEPATOLOGY

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection

(2020) Wenbiao Wang et al.   PLoS Pathogens

Chronically Elevating Circulating Ketones Can Reduce Cardiac Inflammation and Blunt the Development of Heart Failure

(2020) Nikole J. Byrne et al.   Circulation-Heart Failure

Pyroptosis Takes Aim at Neurodevelopment

(2020) Jaeda C. Coutinho-Budd et al.   DEVELOPMENTAL CELL

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

(2020) Susanne Gaul et al.   JOURNAL OF HEPATOLOGY

The activation of IL-17 signaling pathway promotes pyroptosis in pneumonia-induced sepsis

(2020) Li-Li Li et al.   Annals of Translational Medicine

Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy

(2020) Qian Cheng et al.   ACTA PHARMACOLOGICA SINICA

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition

(2020) Wanfeng Xu et al.   Cell Metabolism

Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

(2020) Eun Hee Koh et al.   GUT

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling

(2019) Takeshi Suetomi et al.   CIRCULATION

ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination

(2019) Guangming Ren et al.   EMBO JOURNAL

p300 Acetyltransferase Is a Cytoplasm‐to‐Nucleus Shuttle for SMAD2/3 and TAZ Nuclear Transport in Transforming Growth Factor β–Stimulated Hepatic Stellate Cells

(2019) Yuanguo Wang et al.   HEPATOLOGY

NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice

(2019) Haining Wang et al.   LIFE SCIENCES

The role of inflammasomes in kidney disease

(2019) Takanori Komada et al.   Nature Reviews Nephrology

Specific Inhibition of the NLRP3 Inflammasome as an Anti-Inflammatory Strategy in Cystic Fibrosis

(2019) Oliver J McElvaney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cystic Fibrosis Lung Disease and Immunometabolism: Targeting the NLRP3 Inflammasome

(2019) André M. Cantin   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury

(2019) Carolina Jimenez Calvente et al.   MOLECULAR THERAPY

Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial

(2019) Piero Ruscitti et al.   PLOS MEDICINE

GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation

(2019) Soo Jung Cho et al.   THORAX

Autophagy Attenuates Angiotensin II-Induced Pulmonary Fibrosis by Inhibiting Redox Imbalance-Mediated NOD-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation

(2018) Ying Meng et al.   ANTIOXIDANTS & REDOX SIGNALING

The use of interleukin 1 receptor antagonist (anakinra) in Kawasaki disease: A retrospective cases series

(2018) Isabelle Kone-Paut et al.   AUTOIMMUNITY REVIEWS

NLRP3 Inflammasome Activation Contributes to Mechanical Stretch–Induced Endothelial-Mesenchymal Transition and Pulmonary Fibrosis

(2018) Zhou Lv et al.   CRITICAL CARE MEDICINE

NLRC5 deficiency ameliorates diabetic nephropathy through alleviating inflammation

(2018) Peipei Luan et al.   FASEB JOURNAL

Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice

(2018) Cynthia Lebeaupin et al.   HEPATOLOGY

Ginsenoside 25-OCH3-PPD Promotes Activity of LXRs To Ameliorate P2X7R-Mediated NLRP3 Inflammasome in the Development of Hepatic Fibrosis

(2018) Xin Han et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

(2018) Shouya Feng et al.   JOURNAL OF MOLECULAR BIOLOGY

Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD

(2018) Takanori Komada et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury

(2018) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Fluorofenidone attenuates interleukin-1β production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction

(2018) Linfeng Zheng et al.   NEPHROLOGY

FUNDC1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation

(2018) Wenhui Li et al.   HEPATOLOGY

NLRP3 inflammasome activation in hepatic stellate cells induces murine liver fibrosis

(2018) Maria Eugenia Inzaugarat et al.   HEPATOLOGY

Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis and inflammation in mice

(2018) Aditya Ambade et al.   HEPATOLOGY

Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

(2018) Wu Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The role of mitochondria in NLRP3 inflammasome activation

(2018) Qiuyun Liu et al.   MOLECULAR IMMUNOLOGY

Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation

(2018) Kristina Scheibe et al.   GASTROENTEROLOGY

IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult

(2017) Han Xiao et al.   EUROPEAN HEART JOURNAL

Hepatitis C virus-induced CCL5 secretion from macrophages activates hepatic stellate cells

(2017) Reina Sasaki et al.   HEPATOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis

(2017) Hsi-Hua Chi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Inflammasomes in Liver Fibrosis

(2017) Fernando Alegre et al.   SEMINARS IN LIVER DISEASE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Repetitive Dosing of Fumed Silica Leads to Profibrogenic Effects through Unique Structure–Activity Relationships and Biopersistence in the Lung

(2016) Bingbing Sun et al.   ACS Nano

Angiotensin-(1–7) Improves Liver Fibrosis by Regulating the NLRP3 Inflammasome via Redox Balance Modulation

(2016) Shuang-Ming Cai et al.   ANTIOXIDANTS & REDOX SIGNALING

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung

(2016) Ismini Lasithiotaki et al.   EUROPEAN RESPIRATORY JOURNAL

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

(2016) Isis Ludwig-Portugall et al.   KIDNEY INTERNATIONAL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Molecular Activation of the NLRP3 Inflammasome in Fibrosis: Common Threads Linking Divergent Fibrogenic Diseases

(2015) Carol M. Artlett et al.   ANTIOXIDANTS & REDOX SIGNALING

The Angiotensin-Converting Enzyme 2/Angiotensin (1–7)/Mas Axis Protects Against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-Derived ROS-Mediated RhoA/Rho Kinase Pathway

(2015) Ying Meng et al.   ANTIOXIDANTS & REDOX SIGNALING

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis

(2015) Beatriz Lozano-Ruiz et al.   JOURNAL OF HEPATOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes

(2015) Bingbing Sun et al.   Small

Gadolinium-based compounds induce NLRP3-dependent IL-1β production and peritoneal inflammation

(2014) Christian Schmidt-Lauber et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflammasomes in Respiratory Disease

(2014) Guy G. Brusselle et al.   CHEST

The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance

(2014) P. C. M. van Poppel et al.   DIABETES OBESITY & METABOLISM

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

(2014) Salik Hussain et al.   Particle and Fibre Toxicology

Why does the hemolytic activity of silica predict its pro-inflammatory activity?

(2014) Cristina Pavan et al.   Particle and Fibre Toxicology

Nlrp3 Prevents Early Renal Interstitial Edema and Vascular Permeability in Unilateral Ureteral Obstruction

(2014) Wilco P. Pulskens et al.   PLoS One

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice

(2013) Samuele De Minicis et al.   HEPATOLOGY

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status

(2013) Yuko Nishi et al.   KIDNEY INTERNATIONAL

Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation

(2013) Pieter J. Bakker et al.   KIDNEY INTERNATIONAL

Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells

(2013) Jedd M Hillegass et al.   Particle and Fibre Toxicology

Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention

(2013) Livingston Van De Water et al.   Advances in Wound Care

Recognition of Bacteria by Inflammasomes

(2012) Jakob von Moltke et al.   Annual Review of Immunology

Elovl6 promotes nonalcoholic steatohepatitis

(2012) Takashi Matsuzaka et al.   HEPATOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasomes in wound healing and fibrosis

(2012) Carol M Artlett   JOURNAL OF PATHOLOGY

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Mechanisms of cerebrovascular protection: oestrogen, inflammation and mitochondria

(2010) S. P. Duckles et al.   Acta Physiologica

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Effects of interleukin-18 on cardiac fibroblast function and gene expression

(2010) Charity Fix et al.   CYTOKINE

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis

(2009) Fiona Oakley et al.   GASTROENTEROLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY