Review
Immunology
Ting-Ting Chen, Feng Xiao, Nan Li, Shan Shan, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Wei Wei, Wu-Yi Sun
Summary: Fibrosis, the final stage of chronic inflammation, remains poorly understood in terms of its molecular mechanisms. The inflammasome, a protein complex key to host immunity, has been found to play a crucial role in regulating cytokine responses and potentially serving as novel targets for antifibrotic therapies.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Medicinal
Yan Jiao, Jinshan Nan, Bo Mu, Yun Zhang, Nenghua Zhou, Shunhua Yang, Shanshan Zhang, Wanting Lin, Falu Wang, Anjie Xia, Zhixing Cao, Pei Chen, Zhiling Pan, Guifeng Lin, Shulei Pan, Huachao Bin, Linli Li, Shengyong Yang
Summary: By screening against NLRP3-dependent pyroptosis, a novel compound J114 was discovered, which displayed significant inhibitory activity against human cell pyroptosis and showed distinct differences from existing pyroptosis inhibitors. Further studies revealed that J114 inhibited inflammasome activation by disrupting the interaction between NLRP3 or AIM2 and the adaptor protein ASC.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Virology
Hannah L. Wallace, Rodney S. Russell
Summary: It is well-known that viruses can activate various inflammasomes, leading to programmed cell death and release of inflammatory cytokines. Traditionally, RNA viruses were thought to activate NLRP3 inflammasomes, while DNA viruses activate AIM2 inflammasomes. However, recent research suggests that viruses can activate multiple inflammasome sensors simultaneously.
Article
Microbiology
Bangzuo Ning, Jingjing Shen, Fanglin Liu, Hemin Zhang, Xin Jiang
Summary: Current strategies for treating drug-resistant tuberculosis are limited in effectiveness and have undesirable side effects. Therefore, research on new treatments, including innovative medications, is required. Host-directed therapy (HDT) has emerged as a viable strategy for enhancing protective immunity against infections. In this study, baicalein, derived from Scutellariae radix, was found to inhibit pyroptosis in Mycobacterium tuberculosis-infected macrophages and promote autophagy, suggesting its potential as a new adjunctive HDT drug.
MICROBIOLOGY SPECTRUM
(2023)
Review
Immunology
Jiwen Fan, Meng Ren, Binay Kumar Adhikari, Haodong Wang, Yuquan He
Summary: Cardiac fibrosis has detrimental effects on cardiovascular health, but there is currently no targeted therapy available. Inflammation plays a crucial role in the development of cardiac fibrosis, and the NLRP3 inflammasome is closely linked with innate immunity. Understanding the role of the inflammasome in cardiac fibrosis could lead to novel strategies for prevention and treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Virology
Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
Summary: AIM2 is a cytosolic DNA sensor that plays a critical role in innate immune responses against invading pathogens. VP22, a virion tegument protein of HSV-1, has been found to inhibit AIM2 inflammasome activation by preventing AIM2 oligomerization. This study highlights the importance of VP22's DNA binding activity in inhibiting AIM2 inflammasome activation in HSV-1-infected cells.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yongzhen Mo, Yumin Wang, Shuai Zhang, Fang Xiong, Qijia Yan, Xianjie Jiang, Xiangying Deng, Yian Wang, Chunmei Fan, Le Tang, Shanshan Zhang, Zhaojian Gong, Fuyan Wang, Qianjin Liao, Can Guo, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong
Summary: Our study revealed that a novel circRNA, circRNF13, plays a crucial role in NPC development through the circRNF13-SUMO2-GLUT1 axis. CircRNF13 inhibits NPC proliferation and metastasis by activating SUMO2 and regulating the AMPK-mTOR pathway to inhibit glycolysis. This research provides a theoretical basis for further understanding NPC pathogenesis and developing targeted therapies.
Article
Cell Biology
Claudia Feriotti, Joana Sa-Pessoa, Ricardo Calderon-Gonzalez, Lili Gu, Brenda Morris, Ryoichi Sugisawa, Jose L. Insua, Michael Carty, Amy Dumigan, Rebecca J. Ingram, Adrien Kissenpfening, Andrew G. Bowie, Jose A. Bengoechea
Summary: Klebsiella pneumoniae uses SARM1 protein to counteract host immunity and regulate inflammation and MAP kinase activation. Inhibiting SARM1 may be beneficial for treating Klebsiella infections.
Article
Multidisciplinary Sciences
Dong Wang, Junwei Zou, Jun Dai, Zhengwu Cheng
Summary: The study revealed that AIM2 expression was significantly down-regulated in gastric cancer tissues, associated with tumor size, lymph node metastasis, tumor staging, and poor prognosis in patients. Knockdown of AIM2 promoted cellular proliferation and migration, while overexpression had the opposite effect. Mechanistically, AIM2 was found to regulate the AKT signaling pathway, indicating a potential new target for gastric cancer treatment.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Han Wang, Zongwen Liang, Yanling Gou, Zhi Li, Yingying Cao, Na Jiao, Jiahuan Tan, Yangyang Yu, Zongfeng Zhang
Summary: The m6A methylation mechanism of FTO plays an important role in regulating the development of endometriosis. FTO downregulation in endometriotic stromal cells leads to decreased ATG5 expression, which in turn affects glycolysis, proliferation, and metastasis through the ATG5/PKM2 pathway.
CELLULAR SIGNALLING
(2022)
Article
Dermatology
Tianyu Cao, Xu Yuan, Hui Fang, Jiaoling Chen, Ke Xue, Zhiguo Li, Erle Dang, Gang Wang, Shuai Shao
Summary: This study demonstrates that NETs can activate the AIM2 inflammasome in keratinocytes through the p38-MAPK signaling pathway, promoting the production of IL-1 beta and IFN-gamma. This finding reveals the regulatory roles of NETs in psoriasis and suggests that they might be a potential target for psoriasis therapy.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Yong Wu, Huan Yang, Ming Cheng, Jialin Shi, Weichen Zhang, Shaojun Liu, Minmin Zhang
Summary: This study aimed to investigate the mechanism of action of the calpain inhibitor calpeptin in acute kidney injury. The results showed that calpeptin improved renal functional deterioration and attenuated pathological structure damage in an IR injury-induced AKI mouse model. Mechanistically, calpeptin suppressed the activation of the AIM2 inflammasome and increased Klotho protein levels.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Wei Wang, Yue Zhang, Wenhui Huang, Yafei Yuan, Qiaohui Hong, Zhanzhan Xie, Lijuan Li, Yixin Chen, Xu Li, Ying Meng
Summary: In this study, it was found that ALA can attenuate TGF-beta 1-induced fibroblast activation by regulating aerobic glycolysis and mitophagy. ALA reduces glycolysis by downregulating HK2 and PFKFB3 expression, which leads to decreased fibroblast activation. ALA also inhibits TGF-beta 1-induced mitophagy, further preventing the enhancement of glycolysis. Animal experiments also showed that ALA reverses the effects of bleomycin on HK2, PFKFB3, LC3, Parkin, and fibroblast activation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Qi Yuan, Jie Zhang, Yu Liu, Haiqiang Chen, Haiyang Liu, Jinyan Wang, Meng Niu, Lingling Hou, Zhenlong Wu, Zhinan Chen, Jinhua Zhang
Summary: MyD88 in myofibroblasts plays a critical role in promoting hepatocellular carcinoma by affecting aerobic glycolysis in cancer cells. MyD88 deficiency in myofibroblasts attenuates liver fibrosis and liver cancer tissue. Mechanistically, MyD88 signaling in myofibroblasts increases the secretion of CCL20, which promotes aerobic glycolysis in cancer cells. This process is dependent on the CCR6 receptor and ERK/PKM2 signaling.
JOURNAL OF PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Yujie Zhu, Mingchao Zhang, Weiran Wang, Shuang Qu, Minghui Liu, Weiwei Rong, Wenwen Yang, Hongwei Liang, Caihong Zeng, Xiaodong Zhu, Limin Li, Zhihong Liu, Ke Zen
Summary: Reduction of renal tubular cell PNPT1 causes renal tubular translation arrest and atrophy, which leads to tubular injury. Increasing PNPT1 expression can alleviate tubular injury.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Ermias Jirru, Stefi Lee, Rebecca Harris, Jianjun Yang, Soo Jung Cho, Heather Stout-Delgado
Article
Respiratory System
Soo Jung Cho, Kyung Sook Hong, Edward Schenck, Stefi Lee, Rebecca Harris, Jianjun Yang, Augustine M. K. Choi, Heather Stout-Delgado
Summary: In this study, the impact of chronological aging on tryptophan metabolism in response to influenza infection was investigated. The findings suggest that older individuals exhibit decreased tryptophan metabolism in response to influenza, leading to increased inflammation and reduced regulatory responses. Treatment with a mitochondrial targeted antioxidant improved mitochondrial function and restored tryptophan metabolism in aged mice, offering a potential therapeutic approach to enhance immunometabolic responses in this population.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Rebecca Harris, Jianjun Yang, Kassandra Pagan, Soo Jung Cho, Heather Stout-Delgado
Summary: Influenza infection can lead to acute pneumonia in individuals over 65 years of age, with dysregulated activation of key signaling pathways in the aged lung contributing to increased lung inflammation and morbidity. Significant changes in genes associated with TLR and RIG-I signaling were detected in aged murine lung in response to H1N1 or H3N2 infection within the first seven days. The study results expand the current understanding of age-associated changes in antiviral signaling in the lung.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kyung Sook Hong, Kassandra Pagan, William Whalen, Rebecca Harris, Jianjun Yang, Heather Stout-Delgado, Soo Jung Cho
Summary: Influenza infection induces lung epithelial cell death through suppressed glutathione metabolism, leading to inflammation and injury, which contributes to increased morbidity and mortality.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Seung Min Baik, Jin Park, Tae Yoon Kim, Kyung Sook Hong
Summary: This study analyzed the results of apnea tests performed in a South Korean institution and found that a short-term apnea test protocol is effective for organ preservation for donation.
Article
Medicine, General & Internal
Seung-Min Baik, Miae Lee, Kyung-Sook Hong, Dong-Jin Park
Summary: This study aims to develop machine-learning models to predict COVID-19 mortality and identify key features. The results showed that the deep-learning model performed better, but the ensemble model combining DL and ML had the best performance. Additionally, the Shapley Additive exPlanations method was used to extract feature importance.
Article
Critical Care Medicine
Seung Min Baik, Jin Park, Tae Yoon Kim, Se Hong Choi, Kyung Sook Hong
Summary: This study investigated the effectiveness of presepsin as a sepsis biomarker and found that presepsin can serve as an effective predictor of sepsis-induced mortality and as an evaluation tool for treatment effectiveness.
ACUTE AND CRITICAL CARE
(2022)
Article
Cell Biology
Soo Jung Cho, Alexander Pronko, Jianjun Yang, Kassandra Pagan, Heather Stout-Delgado
Summary: This study investigates the role of Ch25h in modulating innate immune responses by macrophages during Streptococcus pneumoniae infection. The findings demonstrate the important role of Ch25h in regulating the production of inflammatory cytokines and bacterial clearance in the lung.
Meeting Abstract
Critical Care Medicine
Kyung Sook Hong, Seung Min Baik, Tae Yoon Kim
CRITICAL CARE MEDICINE
(2023)
Article
Surgery
Seung Min Baik, Jin Park, Tae Yoon Kim, Jung Hwa Lee, Kyung Sook Hong
Summary: This study retrospectively analyzed medical records of 442 patients and found that 50% of patients who were not brain-dead but discontinued life-sustaining treatment were eligible for organ donation. However, patients and caregivers were unaware of this option due to current legal restrictions on discussing such donations.
ANNALS OF TRANSPLANTATION
(2021)
Article
Respiratory System
Edward J. Schenck, Katherine L. Hoffman, Clara Oromendia, Elizabeth Sanchez, Eli J. Finkelsztein, Kyung Sook Hong, Joseph Kabariti, Lisa K. Torres, John S. Harrington, Ilias I. Siempos, Augustine M. K. Choi, Thomas R. Campion
Summary: Using physiologic and statistical substitution methods improved the total SOFA score's ability to discriminate mortality compared with the missing-as-normal technique. Treating missing data as normal may result in underreporting the severity of illness. The simplicity of a direct oxygen saturation as measured by pulse oximetry/FIO2 ratio-modified SOFA technique makes it an attractive choice for electronic health record-based research.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Meeting Abstract
Immunology
Heather W. Stout-Delgado, Rebecca Harris, Jianjun Yang, Kyung Sook Hong, Soo Jung Cho
JOURNAL OF IMMUNOLOGY
(2020)
Article
Critical Care Medicine
Seo In Lee, Kyung Sook Hong, Jin Park, Young-Joo Lee
ACUTE AND CRITICAL CARE
(2020)