Chronically Elevating Circulating Ketones Can Reduce Cardiac Inflammation and Blunt the Development of Heart Failure

Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure

(2020) Nikole J. Byrne et al.   Circulation-Heart Failure

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling

(2019) Takeshi Suetomi et al.   CIRCULATION

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome

(2019) Maria Consiglia Trotta et al.   PLoS One

Cardiovascular Effects of Treatment with the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients

(2019) Roni Nielsen et al.   CIRCULATION

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

α1-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation

(2019) Jun-zhou Xin et al.   ACTA PHARMACOLOGICA SINICA

The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury

(2018) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Plasma levels of heart failure biomarkers are primarily a reflection of extracardiac production

(2018) Weijie Du et al.   Theranostics

Cardioprotective Effects of CYP-Derived Epoxy Metabolites of Docosahexaenoic Acid Involve Limiting NLRP3 Inflammasome Activation

(2018) Ahmed M. Darwesh et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension

(2018) Saroj Chakraborty et al.   Cell Reports

Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses

(2017) Takehiko Yamanashi et al.   Scientific Reports

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

(2017) Emily L. Goldberg et al.   Cell Reports

Ketone Body Infusion With 3‐Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study

(2017) Lars C. Gormsen et al.   Journal of the American Heart Association

Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes

(2016) Pete J. Cox et al.   Cell Metabolism

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

(2016) Kenneth C. Bedi et al.   CIRCULATION

The Failing Heart Relies on Ketone Bodies as a Fuel

(2016) Gregory Aubert et al.   CIRCULATION

Novel ketone diet enhances physical and cognitive performance

(2016) Andrew J. Murray et al.   FASEB JOURNAL

β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation

(2016) Ha Ram Bae et al.   Oncotarget

The Importance of NLRP3 Inflammasome in Heart Failure

(2015) Brittany Butts et al.   JOURNAL OF CARDIAC FAILURE

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Metabolomic Fingerprint of Heart Failure with Preserved Ejection Fraction

(2015) Beshay N. Zordoky et al.   PLoS One

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

�-Hydroxybutyrate Activates the NF-κB Signaling Pathway to Promote the Expression of Pro-Inflammatory Factors in Calf Hepatocytes

(2014) Xiaoxia Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression

(2014) Willeke M.C. Jong et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

BHBA Suppresses LPS-Induced Inflammation in BV-2 Cells by Inhibiting NF-κB Activation

(2014) Shou-Peng Fu et al.   MEDIATORS OF INFLAMMATION

1H-NMR-Based Metabolic Analysis of Human Serum Reveals Novel Markers of Myocardial Energy Expenditure in Heart Failure Patients

(2014) Zhiyong Du et al.   PLoS One

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation

(2012) David G. Cotter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Urinary ketone is associated with the heart failure severity

(2012) Ji Hyung Chung et al.   CLINICAL BIOCHEMISTRY

Fibrosis and heart failure

(2012) Ana Maria Segura et al.   HEART FAILURE REVIEWS

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Obligate Role for Ketone Body Oxidation in Neonatal Metabolic Homeostasis

(2011) David G. Cotter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart

(2010) E. E. Creemers et al.   CARDIOVASCULAR RESEARCH

Inflammatory Biomarkers in Heart Failure Revisited: Much More than Innocent Bystanders

(2009) Stephan von Haehling et al.   Heart Failure Clinics

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

(2008) Marwan Maalouf et al.   BRAIN RESEARCH REVIEWS

Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: An independent predictor of mortality

(2008) S. Frantz et al.   EUROPEAN JOURNAL OF HEART FAILURE