Why does the hemolytic activity of silica predict its pro-inflammatory activity?

Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants

(2014) Silke Neumann et al.   IMMUNOLOGY AND CELL BIOLOGY

Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation

(2014) Joyce K Thompson et al.   Particle and Fibre Toxicology

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

(2014) Paul M Peeters et al.   Particle and Fibre Toxicology

In Search of the Chemical Basis of the Hemolytic Potential of Silicas

(2013) Cristina Pavan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

(2013) Moritz Haneklaus et al.   CURRENT OPINION IN IMMUNOLOGY

Purification and sidewall functionalization of multiwalled carbon nanotubes and resulting bioactivity in two macrophage models

(2013) Raymond F. Hamilton et al.   INHALATION TOXICOLOGY

Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model

(2013) Tina M. Sager et al.   Nanotoxicology

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

(2013) Wan-Seob Cho et al.   Particle and Fibre Toxicology

Carbon in Intimate Contact with Quartz Reduces the Biological Activity of Crystalline Silica Dusts

(2012) Mara Ghiazza et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Biochemical regulation of the inflammasome

(2012) Jennifer K. Dowling et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic

(2012) Haiyuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A short history of the toxicology of inhaled particles

(2012) Ken Donaldson et al.   Particle and Fibre Toxicology

Comparison of non-crystalline silica nanoparticles in IL-1β release from macrophages

(2012) Wiggo J Sandberg et al.   Particle and Fibre Toxicology

Physicochemical Determinants in the Cellular Responses to Nanostructured Amorphous Silicas

(2012) Elena Gazzano et al.   TOXICOLOGICAL SCIENCES

Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity

(2011) Tian Yu et al.   ACS Nano

The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1β production, ROS production and endosomal rupture

(2010) Tomohiro Morishige et al.   BIOMATERIALS

Does Vitreous Silica Contradict the Toxicity of the Crystalline Silica Paradigm?

(2010) Mara Ghiazza et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

Influence of size, surface area and microporosity on thein vitrocytotoxic activity of amorphous silica nanoparticles in different cell types

(2010) Virginie Rabolli et al.   Nanotoxicology

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

(2010) Meike Winter et al.   Nanotoxicology

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The nanosilica hazard: another variable entity

(2010) Dorota Napierska et al.   Particle and Fibre Toxicology

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy of Simple Short-Term in Vitro Assays for Predicting the Potential of Metal Oxide Nanoparticles to Cause Pulmonary Inflammation

(2008) Senlin Lu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Nominal and Effective Dosimetry of Silica Nanoparticles in Cytotoxicity Assays

(2008) Dominique Lison et al.   TOXICOLOGICAL SCIENCES