Fluorofenidone attenuates interleukin-1β production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction

The intersection of cell death and inflammasome activation

(2016) James E. Vince et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fluorofenidone attenuates pulmonary inflammation and fibrosisviainhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88/NF-κB pathway

(2016) Cheng Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation

(2015) Prajwal Gurung et al.   AMERICAN JOURNAL OF PATHOLOGY

The Protective Mechanism of Fluorofenidone in Renal Interstitial Inflammation and Fibrosis

(2015) Yiting Tang et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice

(2015) Hiroyuki Kadoya et al.   FASEB JOURNAL

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

Fluorofenidone inhibits macrophage IL-1β production by suppressing inflammasome activity

(2015) Miaomiao Lu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ghrelin Attenuates Renal Fibrosis and Inflammation of Obstructive Nephropathy

(2015) Guang-Xi Sun et al.   JOURNAL OF UROLOGY

Fluorofenidone protects against renal fibrosis by inhibiting STAT3 tyrosine phosphorylation

(2015) Juan Tang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

(2015) Chul-Su Yang et al.   Nature Communications

Inflammatory processes in renal fibrosis

(2014) Xiao-Ming Meng et al.   Nature Reviews Nephrology

Nlrp3 Prevents Early Renal Interstitial Edema and Vascular Permeability in Unilateral Ureteral Obstruction

(2014) Wilco P. Pulskens et al.   PLoS One

Fluorofenidone Offers Improved Renoprotection at Early Interventions during the Course of Diabetic Nephropathy in db/db Mice via Multiple Pathways

(2014) Xuan Xiong et al.   PLoS One

CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction

(2014) Sayaka Ito et al.   ARTHRITIS RESEARCH & THERAPY

Fluorofenidone attenuates hepatic fibrosis by suppressing the proliferation and activation of hepatic stellate cells

(2013) Yu Peng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways

(2013) Yu Peng et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Fluorofenidone Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Via Restoring Caveolin 1 Expression and Inhibiting Mitogen-Activated Protein Kinase Signaling Pathway

(2012) Jie Meng et al.   SHOCK

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

A clinical perspective of IL-1β as the gatekeeper of inflammation

(2011) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Fluorofenidone inhibits Ang II-induced apoptosis of renal tubular cells through blockage of the Fas/FasL pathway

(2011) Wang-bin Ning et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fluorofenidone attenuates renal interstitial fibrosis in the rat model of obstructive nephropathy

(2011) Bing-xin Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Fluorofenidone protects mice from lethal endotoxemia through the inhibition of TNF-α and IL-1β release

(2010) Yiting Tang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanistic connection between inflammation and fibrosis

(2010) Soo Bong Lee et al.   KIDNEY INTERNATIONAL