Gadolinium-based compounds induce NLRP3-dependent IL-1β production and peritoneal inflammation

Induction of a type I interferon signature in normal human monocytes by gadolinium-based contrast agents: comparison of linear and macrocyclic agents

(2013) P. J. Wermuth et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Lipopolysaccharide-Induced M2 to M1 Macrophage Transformation for IL-12p70 Production Is Blocked by Candida albicans Mediated Up-Regulation of EBI3 Expression

(2013) Xing-Feng Zheng et al.   PLoS One

Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1  and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

(2012) L. Bossaller et al.   JOURNAL OF IMMUNOLOGY

Gadolinium Compounds Signaling through TLR 4 and TLR 7 in Normal Human Macrophages: Establishment of a Proinflammatory Phenotype and Implications for the Pathogenesis of Nephrogenic Systemic Fibrosis

(2012) P. J. Wermuth et al.   JOURNAL OF IMMUNOLOGY

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis

(2011) Carol M. Artlett et al.   ARTHRITIS AND RHEUMATISM

Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion

(2011) Yohei Ikezumi et al.   HISTOPATHOLOGY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Nephrogenic systemic fibrosis: Clinicopathological definition and workup recommendations

(2011) Michael Girardi et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Persistent activation of dermal fibroblasts from patients with gadolinium-associated nephrogenic systemic fibrosis

(2010) S. Piera-Velazquez et al.   ANNALS OF THE RHEUMATIC DISEASES

Gadolinium and systemic fibrosis: guilt by association

(2010) J. Kay et al.   ANNALS OF THE RHEUMATIC DISEASES

NF B activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis

(2010) F. D. Galdo et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of interleukin-1β by interferon-γ is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production

(2010) Seth L Masters et al.   EMBO REPORTS

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Stability of Gadolinium-Based Magnetic Resonance Imaging Contrast Agents in Human Serum at 37°C

(2010) Thomas Frenzel et al.   INVESTIGATIVE RADIOLOGY

Poly(I:C) Drives Type I IFN- and TGFβ-Mediated Inflammation and Dermal Fibrosis Simulating Altered Gene Expression in Systemic Sclerosis

(2010) Giuseppina A. Farina et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Effect of Different Classes of Gadolinium-based Contrast Agents on Control and Nephrogenic Systemic Fibrosis–derived Fibroblast Proliferation

(2010) Michael Edward et al.   RADIOLOGY

Induction of the expression of profibrotic cytokines and growth factors in normal human peripheral blood monocytes by gadolinium contrast agents

(2009) Peter J. Wermuth et al.   ARTHRITIS AND RHEUMATISM

Caspase 1–independent activation of interleukin-1β in neutrophil-predominant inflammation

(2009) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates

(2009) Pablo Pelegrin et al.   EMBO JOURNAL

The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis – A mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide

(2009) T. Steger-Hartmann et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma

(2009) Nobuyo Higashi-Kuwata et al.   EXPERIMENTAL DERMATOLOGY

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Dermal Fibroblasts Promote the Migration of Dendritic Cells

(2009) Anja Saalbach et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Case 6-2008

(2008) Jonathan Kay et al.   NEW ENGLAND JOURNAL OF MEDICINE