Iron Metabolism in Pancreatic Beta-Cell Function and Dysfunction

The Pancreatic β-Cell: The Perfect Redox System

(2021) Petr Ježek et al.   Antioxidants

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

(2020) Ross A. Weber et al.   MOLECULAR CELL

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

(2020) Maria C. Ferreira dos Santos et al.   Nature Communications

Identification of Frataxin as a regulator of ferroptosis

(2020) Jing Du et al.   Redox Biology

Shaping Pancreatic β-Cell Differentiation and Functioning: The Influence of Mechanotransduction

(2020) Galli Alessandra et al.   Cells

Genetic and Clinical Heterogeneity in Thirteen New Cases with Aceruloplasminemia. Atypical Anemia as a Clue for an Early Diagnosis

(2020) Marc Vila Cuenca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention

(2020) Andrew Tsatsanis et al.   MOLECULAR PSYCHIATRY

Regulation of iron homeostasis: Lessons from mouse models

(2020) Sandro Altamura et al.   MOLECULAR ASPECTS OF MEDICINE

Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta-cells

(2020) C. Berthault et al.   Molecular Metabolism

Proteomic Analysis Reveals a Mitochondrial Remodeling of βTC3 Cells in Response to Nanotopography

(2020) Elisa Maffioli et al.   Frontiers in Cell and Developmental Biology

Human islet amyloid polypeptide (hIAPP) - a curse in type II diabetes mellitus: insights from structure and toxicity studies

(2020) Ajit Kumar Bishoyi et al.   BIOLOGICAL CHEMISTRY

Regulatory Connections between Iron and Glucose Metabolism

(2020) Carine Fillebeen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes

(2020) Dan Li et al.   Nutrients

Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux

(2019) Adrienne C. Dlouhy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferroptosis as a novel therapeutic target for Friedreich's ataxia

(2019) M. Grazia Cotticelli et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic β-cell dysfunction

(2019) Tingting Shu et al.   Endocrine Connections

Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis

(2019) Yvette C. Wong et al.   TRENDS IN CELL BIOLOGY

Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis

(2019) Andrew Tsatsanis et al.   NEUROCHEMICAL RESEARCH

Transferrin receptor 1 overexpression is associated with tumor dedifferentiation and acts as a potential prognostic indicator of hepatocellular carcinoma

(2019) Makiko Adachi et al.   HISTOPATHOLOGY

Concise Review: Beta-Cell Dedifferentiation in Type 2 Diabetes

(2019) Shimon Efrat   STEM CELLS

The zinc transporter Zip14 (SLC39a14) affects Beta-cell Function: Proteomics, Gene expression, and Insulin secretion studies in INS-1E cells

(2019) Trine Maxel et al.   Scientific Reports

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

Circadian clock gene NPAS2 promotes reprogramming of glucose metabolism in hepatocellular carcinoma cells

(2019) Peng Yuan et al.   CANCER LETTERS

Association between the ferritin level and risk of gestational diabetes mellitus: A meta‐analysis of observational studies

(2019) Ce Sun et al.   Journal of Diabetes Investigation

Metabolic activation-driven mitochondrial hyperpolarization predicts insulin secretion in human pancreatic beta-cells

(2018) Akos A. Gerencser   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells

(2018) Moon-Suhn Ryu et al.   BLOOD CELLS MOLECULES AND DISEASES

Link of impaired metal ion homeostasis to mitochondrial dysfunction in neurons

(2018) Eunju Nam et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Clock genes alterations and endocrine disorders

(2018) Anna Angelousi et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Glucolipotoxic conditions induce β-cell iron import, cytosolic ROS formation and apoptosis

(2018) Jakob Bondo Hansen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

Ferroptosis-inducing agents compromise in vitro human islet viability and function

(2018) Antonio Bruni et al.   Cell Death & Disease

A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese

(2018) Natascha A. Wolff  et al.   Scientific Reports

Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans

(2018) Alessandra Galli et al.   Scientific Reports

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells

(2018) Philip Seibler et al.   BRAIN

DMT1 and iron transport

(2018) Izumi Yanatori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα-dependent manner

(2018) Luqing Zhao et al.   FASEB JOURNAL

The ins and outs of iron: Escorting iron through the mammalian cytosol

(2018) Caroline C. Philpott et al.   FREE RADICAL BIOLOGY AND MEDICINE

Circadian clocks and insulin resistance

(2018) Dirk Jan Stenvers et al.   Nature Reviews Endocrinology

Systematic review and meta-analysis to determine the impact of iron depletion in dysmetabolic iron overload syndrome and non-alcoholic fatty liver disease

(2017) Arvind R. Murali et al.   HEPATOLOGY RESEARCH

Endoplasmic reticulum–mitochondria junction is required for iron homeostasis

(2017) Yong Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

(2017) Moon-Suhn Ryu et al.   JOURNAL OF CLINICAL INVESTIGATION

Uncoupled iron homeostasis in type 2 diabetes mellitus

(2017) Sandro Altamura et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hepcidin links gluco-toxicity to pancreatic beta cell dysfunction by inhibiting Pdx-1 expression

(2017) Xuhua Mao et al.   Endocrine Connections

Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress

(2016) Marie Balslev Backe et al.   Annual Review of Nutrition

Molecular mechanisms of ROS production and oxidative stress in diabetes

(2016) P. Newsholme et al.   BIOCHEMICAL JOURNAL

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Mitochondrial iron overload: causes and consequences

(2016) Tracey A Rouault   CURRENT OPINION IN GENETICS & DEVELOPMENT

Iron: how much is too much?

(2016) Aidan McElduff   DIABETOLOGIA

A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort

(2016) Shristi Rawal et al.   DIABETOLOGIA

Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression

(2016) Fumiyasu Okazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2

(2016) Izumi Yanatori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosome–mitochondria interactions are modulated by iron release from transferrin

(2016) Anupam Das et al.   JOURNAL OF CELL BIOLOGY

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity

(2016) Jack T. Rogers et al.   JOURNAL OF NEUROCHEMISTRY

Fe–oxy adducts of heme–Aβ and heme–hIAPP complexes: intermediates in ROS generation

(2016) Manas Seal et al.   Metallomics

Pica as a manifestation of iron deficiency

(2016) Caterina Borgna-Pignatti et al.   Expert Review of Hematology

Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in insulin insensitivity of mammalian cells

(2015) Chih-Hao Wang et al.   Annals of the New York Academy of Sciences

Weaning Triggers a Maturation Step of Pancreatic β Cells

(2015) Miri Stolovich-Rain et al.   DEVELOPMENTAL CELL

Correction: Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptorsmographic and Clinico-Epidemiological Features of Dengue Fever in Faisalabad, Pakistan

(2015) Paola Llanos et al.   PLoS One

Pancreatic   cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

(2015) M. Perelis et al.   SCIENCE

Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients

(2014) John B. Porter et al.   BRITISH JOURNAL OF HAEMATOLOGY

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

(2014) R. C. McCarthy et al.   EMBO REPORTS

Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1)

(2014) Natascha A. Wolff et al.   FASEB JOURNAL

Sideroblastic Anemia

(2014) Sylvia S. Bottomley et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Pleiotropic actions of iron balance in diabetes mellitus

(2014) Xinhui Wang et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Iron and Diabetes Risk

(2013) Judith A. Simcox et al.   Cell Metabolism

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+homeostasis

(2013) Sandra E. Wiley et al.   EMBO Molecular Medicine

Heme Bound Amylin: Spectroscopic Characterization, Reactivity, and Relevance to Type 2 Diabetes

(2013) Soumya Mukherjee et al.   INORGANIC CHEMISTRY

Each Member of the Poly-r(C)-binding Protein 1 (PCBP) Family Exhibits Iron Chaperone Activity toward Ferritin

(2013) Sebastien Leidgens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Nuclear Factor-κB Activation in Pancreatic β-Cells Has a Protective Effect on Allogeneic Pancreatic Islet Graft Survival

(2013) Roy Eldor et al.   PLoS One

The potential role of glutamate in the current diabetes epidemic

(2012) Alberto M. Davalli et al.   ACTA DIABETOLOGICA

Mammalian iron metabolism and its control by iron regulatory proteins

(2012) Cole P. Anderson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines

(2012) Jakob Bondo Hansen et al.   Cell Metabolism

Evidence for a Role of Frataxin in Pancreatic Islets Isolated from Multi-Organ Donors with and Without Type 2 Diabetes Mellitus

(2012) S. Del Guerra et al.   HORMONE AND METABOLIC RESEARCH

NADPH Inhibits [2Fe-2S] Cluster Protein Transfer from Diabetes Drug Target MitoNEET to an Apo-acceptor Protein

(2012) John A. Zuris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations

(2012) Elmar Aigner et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Increased Serum Hepcidin Levels in Subjects with the Metabolic Syndrome: A Population Study

(2012) Nicola Martinelli et al.   PLoS One

The long history of iron in the Universe and in health and disease

(2011) Alex D. Sheftel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2

(2011) Anjali Nandal et al.   Cell Metabolism

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

(2011) Christine A. Robson-Doucette et al.   DIABETES

The Glial Glutamate Transporter 1 (GLT1) Is Expressed by Pancreatic β-Cells and Prevents Glutamate-induced β-Cell Death

(2011) Eliana S. Di Cairano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein

(2011) John A. Zuris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

To determine the possible roles of two essential trace elements and ascorbic acid concerning amyloidal beta-sheet formation in diabetes mellitus

(2011) Seyyed Mehdi Mirhashemi   Scientific Research and Essays

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic β-cells

(2009) David M. Hudson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanisms of Pancreatic β-Cell Growth and Regeneration: Studies on Rat Insulinoma Cells

(2009) J. Høiriis Nielsen   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2

(2009) Andrea R. Conlan et al.   JOURNAL OF MOLECULAR BIOLOGY

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of iron in type 2 diabetes in humans

(2008) Swapnil N. Rajpathak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES

Pancreatic β-cells express hepcidin, an iron-uptake regulatory peptide

(2008) Hasan Kulaksiz et al.   JOURNAL OF ENDOCRINOLOGY

Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2

(2008) P. N. Paradkar et al.   MOLECULAR AND CELLULAR BIOLOGY

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(2008) Hani Jouihan et al.   MOLECULAR MEDICINE