Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 75, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mam.2020.100872
Keywords
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Funding
- Deutsche Forschungsgemeinschaft [SFB1036, SFB1118]
- Federal Ministry of Education and Research (NephrESA) [031L0191C]
- Ministry of Science, Research and the Arts (MWK) Baden-Wurttemberg (DZL TLRC-H)
- Dietmar Hopp-Stiftung
- DAAD (A New Passage to India)
- European Hematology Association (Advanced Research fellowship)
- Physician Scientist Program of the Medical Faculty Heidelberg
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Iron is an essential micronutrient and a critical cofactor for proteins involved in fundamental processes such as oxygen transport, energy production and DNA synthesis. However, iron levels need to be tightly balanced to avoid pathological consequences of iron overload or deficiency. Genetically engineered mouse models with alterations in systemic or cellular iron handling advanced our knowledge how systemic and cellular iron homeostasis is maintained. Here, we prepared a comprehensive overview of mouse models that provide insight into mechanisms of iron regulation and/or rare or frequent iron-related disorders.
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