Article
Biochemistry & Molecular Biology
Simona Pergolizzi, Alessio Alesci, Antonio Centofanti, Marialuisa Aragona, Socrate Pallio, Ludovico Magaudda, Giuseppina Cutroneo, Eugenia Rita Lauriano
Summary: Crohn's disease is a chronic intestinal inflammation that is associated with inflammatory bowel disease. Intestinal 5-HT signaling is linked to patients with inflammatory bowel disease. Our study reveals the correlation between different types of intestinal cells in maintaining the inflammatory state in Crohn's disease.
Review
Pharmacology & Pharmacy
Dulce C. Macias-Ceja, Maria D. Barrachina, Dolores Ortiz-Masia
Summary: Chronic inflammation is associated with excessive deposition of extracellular matrix and leads to fibrosis. Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD), and deregulated autophagy is linked to fibrosis progression. Understanding the role of autophagy in fibrosis may provide new targets for antifibrotic therapy. This review focuses on the relevance of autophagy in fibrosis, with a special emphasis on IBD-related fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Aito Ueno, Humberto B. Jijon, Richard Peng, Steven Sparksman, Barbara Mainoli, Alexis Filyk, Yan Li, Stephanie Wilson, Kerri Novak, Remo Panaccione, Simon Hirota, Antoine Dufour, Cathy Lu, Paul L. Beck
Summary: This study provides evidence supporting a potential role of fibrocytes in collagen deposition in Crohn's disease strictures and suggests that fibrocyte numbers may predict the need for therapy escalation.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Engineering, Biomedical
Jingbo Zhao, Donghua Liao, Rune Wilkens, Klaus Krogh, Henning Glerup, Hans Gregersen
Summary: This study aimed to quantify the mechanical properties of intestinal stenosis in CD patients and found that the changes in mechanical properties were mainly associated with chronic inflammation, fibrosis, and collagen fraction.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Valentina Garlatti, Sara Lovisa, Silvio Danese, Stefania Vetrano
Summary: Inflammatory Bowel Disease (IBD) is a chronic and relapsing intestinal disease characterized by fibrosis leading to narrowing and closure of the intestine. Integrins play a crucial role in the treatment of IBD by regulating immune cell function and extracellular matrix signaling. Understanding integrin signaling in the context of IBD may provide insights into mechanisms of matrix remodeling independent of inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Claudia Veltkamp, Shuai Lan, Eleni Korompoki, Karl-Heinz Weiss, Hartmut Schmidt, Helmut K. Seitz
Summary: IBD patients often develop liver problems such as hepatic steatosis and fibrosis. Factors associated with hepatic steatosis include age, BMI, disease duration, and specific serum activities. Hepatic fibrosis is more common in CD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Giovanni Cirillo, Flor Negrete-Diaz, Daniela Yucuma, Assunta Virtuoso, Sohaib Ali Korai, Ciro De Luca, Eugenijus Kaniusas, Michele Papa, Fivos Panetsos
Summary: This paper provides a comprehensive overview of the pathogenesis and therapeutic approaches for inflammatory bowel diseases. The interaction between the enteric and central nervous systems and the role of the vagus nerve in autoimmune diseases are highlighted. Neuroprosthetic stimulation of the vagus nerve, particularly transcutaneous stimulation of the auricular branch, has been suggested as a potential therapeutic approach for controlling intestinal inflammation.
Article
Chemistry, Analytical
Baolan Lu, Jinjiang Lin, Jinfang Du, Shaofu He, Qinghua Cao, Li Huang, Ren Mao, Canhui Sun, Ziping Li, Shiting Feng, Xuehua Li
Summary: Native T-1 mapping shows promise as an imaging biomarker for assessing fibrosis severity in Crohn's disease, but its diagnostic performance is not superior to MTI.
Article
Gastroenterology & Hepatology
Giorgos Bamias, Theresa T. Pizarro, Fabio Cominelli
Summary: This review describes the cellular and molecular immunological mechanisms of intestinal fibrosis in IBD, with a particular focus on animal models of intestinal fibrosis. Based on this research, potential future targets for antifibrotic therapies for IBD patients can be identified.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ayaha Yamamoto, Hitomi Morioki, Takafumi Nakae, Yoshiaki Miyake, Takeo Harada, Shunsuke Noda, Sayuri Mitsuoka, Kotaro Matsumoto, Masashi Tomimatsu, Soshi Kanemoto, Shota Tanaka, Makiko Maeda, Simon J. Conway, Kazunori Imaizumi, Yasushi Fujio, Masanori Obana
Summary: The study identified that OASIS in myofibroblasts promotes kidney fibrosis, partially through increased Bst2 expression. Systemic genetic knockout of OASIS reduces myofibroblast proliferation and systemic anti-Bst2 blocking antibody approach attenuates kidney fibrosis in normal mice after UUO.
Article
Cell Biology
Michael P. Czubryt, Taben M. Hale
Summary: Cardiac fibrosis is a characteristic of end-stage heart disease, but there are no approved therapies directly targeting the extracellular matrix. Research on cardiac fibroblasts is hindered by the lack of a clear marker.
CELLULAR SIGNALLING
(2021)
Article
Biotechnology & Applied Microbiology
Yameng Cao, Kai Cheng, Mei Yang, Zhichao Deng, Yana Ma, Xiangji Yan, Yuanyuan Zhang, Zhenzhen Jia, Jun Wang, Kangsheng Tu, Jie Liang, Mingzhen Zhang
Summary: In this study, dextran-coated cerium oxide nanozyme was synthesized and shown to have therapeutic potential for inflammatory bowel disease (IBD) by alleviating oxidative stress and reducing fibrosis. The nanozyme efficiently scavenged reactive oxide species and downregulated pro-inflammatory cytokines, as well as suppressed fibrosis-related gene expression. Additionally, it could be used as a CT contrast agent for noninvasive gastrointestinal tract imaging.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Florian N. Loch, Carsten Kamphues, Katharina Beyer, Christian Schineis, Patrick Asbach, Rolf Reiter, Ingolf Sack, Juergen Braun
Summary: MRE can be used to assess the viscoelastic properties of healthy and CD-affected ileum. The results showed that the penetration rate was lower, and the damping ratio and viscosity parameter were higher in CD-affected tissue compared to healthy tissue. There was no significant difference in shear wave speed between healthy and diseased tissue.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Gastroenterology & Hepatology
Bo Shen
Summary: Endoscopic therapy has become the main treatment for inflammatory bowel diseases and associated complications, such as strictures, fistulas, abscesses, bleeding lesions, and polyps. The development of interventional IBD is supported by a better understanding of the disease process, advancements in endoscopic technology, and the training of next-generation specialists.
GASTROENTEROLOGY REPORT
(2022)
Review
Immunology
Kentaro Iwata, Yohei Mikami, Motohiko Kato, Naohisa Yahagi, Takanori Kanai
Summary: Gastrointestinal fibrosis is a condition of accumulated biological entropy caused by dysregulated tissue repair response, often seen in cases of acute or chronic inflammation in the gastrointestinal tract, particularly in patients with Crohn's disease. Current understanding of the pathogenesis of gastrointestinal fibrosis is limited, highlighting the need for further development of prevention and treatment strategies.
INFLAMMATION AND REGENERATION
(2021)
Review
Gastroenterology & Hepatology
Calen A. Steiner, Jeffrey A. Berinstein, Jeremy Louissaint, Peter D. R. Higgins, Jason R. Spence, Carol Shannon, Cathy Lu, Ryan W. Stidham, Joel G. Fletcher, David H. Bruining, Brian G. Feagan, Vipul Jairath, Mark E. Baker, Dominik Bettenworth, Florian Rieder
Summary: This comprehensive systematic review examines biomarkers for predicting and diagnosing Crohn's disease-associated strictures. Thirty-five potential biomarkers were identified across three groups, including promising markers such as cartilage oligomeric matrix protein and hepatocyte growth factor activator. However, limitations exist, including the lack of standardized definition for stricturing disease and incomplete knowledge of their operating properties.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Laura A. Johnson, Eva S. Rodansky, Anhdao Tran, Stephen G. Collins, Kathryn A. Eaton, Benjamin Malamet, Calen A. Steiner, Sha Huang, Jason R. Spence, Peter D. R. Higgins
Summary: Intestinal fibrosis is a common complication of Crohn's disease with no effective therapies, but targeting the Bcl-2 pathway with ABT-263 shows potential for reducing fibrosis. This study suggests BH-3 mimetics could be a novel antifibrotic therapeutic approach for Crohn's disease.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Pediatrics
Nadeen Abu-Ata, Jonathan R. Dillman, Jonathan M. Rubin, Margaret H. Collins, Laura A. Johnson, Rebecca S. Imbus, Erin L. Bonkowski, Lee A. Denson, Peter D. R. Higgins
Summary: Ultrasound shear wave elastography can evaluate the relationship between bowel wall stiffness and intestinal fibrosis and smooth muscle hypertrophy in surgically resected ileal strictures from pediatric Crohn disease patients.
PEDIATRIC RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Arthur J. Kastl, Kimberly N. Weaver, Xian Zhang, Jennifer A. Strople, Jeremy Adler, Marla C. Dubinsky, Athos Bousvaros, Runa Watkins, Xiangfeng Dai, Wenli Chen, Raymond K. Cross, Peter D. R. Higgins, Ryan C. Ungaro, Meenakshi Bewtra, Emanuelle A. Bellaguarda, Francis A. Farraye, Kelly Y. Chun, Michael Zikry, Manory Fernando, Monique Bastidas, Cristian G. Hernandez, Riley G. Craig, Margie E. Boccieri, Anne Firestine, Millie D. Long, Michael D. Kappelman
Summary: Children with IBD show a robust immune response to COVID-19 vaccination with low adverse events, providing a high level of reassurance to the medical community and patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Letter
Gastroenterology & Hepatology
Kira L. Newman, Kara Jencks, Victor Chedid, Sonali Paul, Peter D. R. Higgins, Sunanda Kane, Millie Long
Article
Gastroenterology & Hepatology
Julian Panes, Edward Loftus, Peter D. R. Higgins, James O. Lindsay, Wen Zhou, Xuan Yao, Dapo Ilo, Charles Phillips, Jacinda Tran, Yuri Sanchez Gonzalez, Severine Vermeire
Summary: The study evaluated the benefits of UPA on the HRQoL of patients with ulcerative colitis, and found that UPA treatment significantly improved patients' quality of life.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Immunology
Jeffrey A. Berinstein, Calen A. Steiner, Samara Rifkin, D. Alexander Perry, Dejan Micic, Daniel Shirley, Peter D. R. Higgins, Vincent B. Young, Allen Lee, Krishna Rao
Summary: By developing and validating a model to predict the risk of complications from CDI, this study demonstrates that it is possible to accurately estimate the risk of CDI complications. The model performed well in a large and diverse population, but showed poorer performance in non-White patients.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Review
Gastroenterology & Hepatology
Elliot M. Berinstein, Jessica L. Sheehan, Janson Jacob, Calen A. Steiner, Ryan W. Stidham, Carol Shannon, Shrinivas Bishu, Jacob Levine, Shirley A. Cohen-Mekelburg, Akbar K. Waljee, Peter D. R. Higgins, Jeffrey A. Berinstein
Summary: Dual targeted therapy is a promising approach for improving the treatment of inflammatory bowel disease in patients who do not respond well to targeted monotherapy. However, more research is needed to confirm its effectiveness and identify the patients who would benefit the most from this treatment.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Remo Panaccione, Eric B. Collins, Gil Y. Melmed, Severine Vermeire, Silvio Danese, Peter D. R. Higgins, Christina S. Kwon, Wen Zhou, Dapo Ilo, Dolly Sharma, Yuri Sanchez Gonzalez, Si-Tien Wang
Summary: Indirect evidence suggests that Upadacitinib may be more effective than other advanced therapies in achieving clinical response, clinical remission, and endoscopic response in patients with moderately to severely active ulcerative colitis over a one-year period, with similar safety profiles across different therapies.
CROHNS & COLITIS 360
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Edward Barnes, Parakkal Deepak, Poonam Beniwal-Patel, Laura Raffals, Maia Kayal, Marla C. Dubinsky, Shannon Chang, Peter D. Higgins, Yue Jiang, Raymond Cross, Millie Long, Hans Herfarth
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Severine Vermeire, Silvio Danese, Wen Zhou, Justin Klaff, Dapo Ilo, Xuan Yao, Gweneth Levy, Peter D. Higgins, Edward V. Loftus, Remo Panaccione
Meeting Abstract
Gastroenterology & Hepatology
Remo Panaccione, Eric B. Collins, Gil Melmed, Severine Vermeire, Silvio Danese, Peter D. Higgins, Wert Zhou, Dapo Ilo, Dolly Sharma, Yuri Sanchez Gonzalez, Si-Tien Wang
Meeting Abstract
Gastroenterology & Hepatology
Remo Panaccione, Anita Afzali, David Hudesman, Garrett Lawlor, Mark T. Osterman, Devrim Eren, Arteid Memaj, Miguel D. Regueiro, Subrata Ghosh
Meeting Abstract
Gastroenterology & Hepatology
S. Vermeire, S. Danese, W. Zhou, J. Klaff, D. Ilo, X. Yao, G. Levy, P. D. R. Higgins, E. V. Loftus-, R. Panaccione
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
R. Panaccione, E. B. Collins, G. Y. Melmed, S. Vermeire, S. Danese, P. D. R. Higgins, W. Zhou, D. Ilo, D. Sharma, Y. Sanchez Gonzalez, S. T. Wang
JOURNAL OF CROHNS & COLITIS
(2022)