Epithelial–mesenchymal transition in Crohn’s disease

MicroRNAs-mediated epithelial-mesenchymal transition in fibrotic diseases

(2017) Xiao-Zhou Zou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Organoid-based epithelial to mesenchymal transition (OEMT) model: from an intestinal fibrosis perspective

(2017) Soojung Hahn et al.   Scientific Reports

Improvements in the Long-Term Outcome of Crohn’s Disease Over the Past Two Decades and the Relation to Changes in Medical Management: Results from the Population-Based IBDSL Cohort

(2016) Steven F G Jeuring et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The effects of Micro-429 on inhibition of cervical cancer cells through targeting ZEB1 and CRKL

(2016) Yan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials

(2016) Nicola A Hanania et al.   Lancet Respiratory Medicine

Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD

(2016) Noam Jacob et al.   United European Gastroenterology Journal

mTOR inhibitors for medical treatment of post-transplantation encapsulating peritoneal sclerosis: a favourable single center experience

(2015) Maria Messina et al.   JOURNAL OF NEPHROLOGY

Origin of myofibroblasts and cellular events triggering fibrosis

(2015) Matthias Mack et al.   KIDNEY INTERNATIONAL

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Biologic agents for IBD: practical insights

(2015) Silvio Danese et al.   Nature Reviews Gastroenterology & Hepatology

Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis

(2014) Satish K. Madala et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeting Interleukin-13 with Tralokinumab Attenuates Lung Fibrosis and Epithelial Damage in a Humanized SCID Idiopathic Pulmonary Fibrosis Model

(2014) Lynne A. Murray et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease

(2014) Krisztina B Gecse et al.   GUT

Results of the 4th scientific workshop of the ECCO (I): Pathophysiology of intestinal fibrosis in IBD

(2014) Giovanni Latella et al.   Journal of Crohns & Colitis

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epithelial-to-mesenchymal transition in a fistula-associated anal adenocarcinoma in a patient with long-standing Crohn’s disease

(2013) Michael Scharl et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

A Role for Tumor Necrosis Factor and Bacterial Antigens in the Pathogenesis of Crohnʼs Disease–Associated Fistulae

(2013) Sandra Michaela Frei et al.   INFLAMMATORY BOWEL DISEASES

Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Utility of a bacterial infection model to study epithelial–mesenchymal transition, mesenchymal–epithelial transition or tumorigenesis

(2013) P Chandrakesan et al.   ONCOGENE

The Role for Dickkopf-Homolog-1 in the Pathogenesis of Crohn’s Disease-Associated Fistulae

(2013) Sandra Michaela Frei et al.   PLoS One

The Gut Microbiome in Intestinal Fibrosis: Environmental Protector or Provocateur?

(2013) F. Rieder   Science Translational Medicine

Colorectal Cancer and Crohn’s Colitis: Clinical Implications From 313 Surgical Patients

(2013) Stefano Scaringi et al.   WORLD JOURNAL OF SURGERY

miR-200b inhibits TGF-β1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells

(2013) Y Chen et al.   Cell Death & Disease

Keloid Disease Can Be Inhibited by Antagonizing Excessive mTOR Signaling With a Novel Dual TORC1/2 Inhibitor

(2012) Farhatullah Syed et al.   AMERICAN JOURNAL OF PATHOLOGY

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Cadherin recognition and adhesion

(2012) Deborah Leckband et al.   CURRENT OPINION IN CELL BIOLOGY

Hospitalisations and surgery in Crohn's disease

(2012) Charles N Bernstein et al.   GUT

Interleukin-13 and transforming growth factor β synergise in the pathogenesis of human intestinal fistulae

(2012) Michael Scharl et al.   GUT

Formation and migration of neural crest cells in the vertebrate embryo

(2012) Marianne E. Bronner   HISTOCHEMISTRY AND CELL BIOLOGY

miR-200b is involved in intestinal fibrosis of Crohn’s disease

(2012) YINGWEI CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

An Evidence-Based Systematic Review on Medical Therapies for Inflammatory Bowel Disease

(2011) Nicholas J Talley et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Guidelines for the management of inflammatory bowel disease in adults

(2011) C. Mowat et al.   GUT

A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis

(2011) Howard Trachtman et al.   KIDNEY INTERNATIONAL

Long-term efficacy of infliximab maintenance therapy for perianal Crohn’s disease

(2011) Motoi Uchino   WORLD JOURNAL OF GASTROENTEROLOGY

Epithelial to Mesenchymal Transition in Human Skin Wound Healing Is Induced by Tumor Necrosis Factor-α through Bone Morphogenic Protein-2

(2010) Chunli Yan et al.   AMERICAN JOURNAL OF PATHOLOGY

The Coagulation System Contributes to αVβ6 Integrin Expression and Liver Fibrosis Induced by Cholestasis

(2010) Bradley P. Sullivan et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease–antiprotease system by the mTOR inhibitor rapamycin

(2010) Bashier Osman et al.   BIOCHEMICAL PHARMACOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

(2010) Melissa G. Mendez et al.   FASEB JOURNAL

Risk Factors Associated With Progression to Intestinal Complications of Crohn's Disease in a Population-Based Cohort

(2010) Kelvin T. Thia et al.   GASTROENTEROLOGY

Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7

(2010) Y. Yin et al.   GUT

Fistula-associated anal adenocarcinoma in Crohnʼs disease

(2010) Igors Iesalnieks et al.   INFLAMMATORY BOWEL DISEASES

Potential role for SNAIL family transcription factors in the etiology of Crohnʼs disease-associated fistulae

(2010) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

Specific differences in migratory function of myofibroblasts isolated from Crohnʼs disease fistulae and strictures

(2010) Johannes K.-H. Meier et al.   INFLAMMATORY BOWEL DISEASES

Identification of Epithelial to Mesenchymal Transition as a Novel Source of Fibroblasts in Intestinal Fibrosis

(2010) Sarah N. Flier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPS-Induced Epithelial-Mesenchymal Transition of Intrahepatic Biliary Epithelial Cells

(2010) Lijin Zhao et al.   JOURNAL OF SURGICAL RESEARCH

Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-β1 in Renal Tubular Epithelial Cells

(2009) Guoping Zheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

(2009) Hervé Acloque et al.   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies

(2009) Mark WJ Ferguson et al.   LANCET

Dkk-1 Inhibits Intestinal Epithelial Cell Migration by Attenuating Directional Polarization of Leading Edge Cells

(2009) Stefan Koch et al.   MOLECULAR BIOLOGY OF THE CELL

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

(2009) Theresa Vincent et al.   NATURE CELL BIOLOGY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

Intestinal fibrosis in IBD—a dynamic, multifactorial process

(2009) Florian Rieder et al.   Nature Reviews Gastroenterology & Hepatology

A Multicenter, Randomized, Double-Blind Trial of EverolimusVersusAzathioprine and Placebo to Maintain Steroid-Induced Remission in Patients With Moderate-to-Severe Active Crohn's Disease

(2008) Walter Reinisch et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

(2008) D C O Massey et al.   GUT

Everolimus for refractory Crohnʼs disease: A case report

(2008) Jérôme Dumortier et al.   INFLAMMATORY BOWEL DISEASES

Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohnʼs disease

(2008) Frauke Bataille et al.   INFLAMMATORY BOWEL DISEASES

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE