Inhibition of Fibroblast Activation Protein Restores a Balanced Extracellular Matrix and Reduces Fibrosis in Crohn’s Disease Strictures Ex Vivo

α-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFβ activation or collagen production across multiple models of organ fibrosis

(2016) Kai-Hui Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Reversibility of Stricturing Crohnʼs Disease—Fact or Fiction?

(2016) Dominik Bettenworth et al.   INFLAMMATORY BOWEL DISEASES

Smooth Muscle Hyperplasia/Hypertrophy is the Most Prominent Histological Change in Crohn’s Fibrostenosing Bowel Strictures: A Semiquantitative Analysis by Using a Novel Histological Grading Scheme

(2016) Wenqian Chen et al.   Journal of Crohns & Colitis

European Crohn’s and Colitis Organisation Topical Review on Prediction, Diagnosis and Management of Fibrostenosing Crohn’s Disease

(2016) Florian Rieder et al.   Journal of Crohns & Colitis

3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management

(2016) Fernando Gomollón et al.   Journal of Crohns & Colitis

Specific inhibition of fibroblast activation protein (FAP)-alpha prevents tumor progression in vitro

(2015) Volker Teichgräber et al.   Advances in Medical Sciences

Pathogenic aspects and therapeutic avenues of intestinal fibrosis in Crohn's disease

(2015) F. Zorzi et al.   CLINICAL SCIENCE

ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation

(2014) Elee Shimshoni et al.   GUT

Mechanisms That Mediate the Development of Fibrosis in Patients With Crohnʼs Disease

(2014) Chao Li et al.   INFLAMMATORY BOWEL DISEASES

Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy

(2014) Elizabeth J. Hamson et al.   Proteomics Clinical Applications

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

(2013) Roosmarijn E. Vandenbroucke et al.   EMBO Molecular Medicine

Tissue Inhibitor of Metalloproteinase-3 Regulates Inflammation in Human and Mouse Intestine

(2012) Ivan Monteleone et al.   GASTROENTEROLOGY

The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells

(2012) Nick Powell et al.   IMMUNITY

Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia

(2012) Felicitas L Koller et al.   LABORATORY INVESTIGATION

TGF-β/Smad Signaling in Kidney Disease

(2012) Hui Y. Lan et al.   SEMINARS IN NEPHROLOGY

Surgery for Crohn’s disease in the era of biologicals: A reduced need or delayed verdict?

(2012) Anthony de Buck van Overstraeten   WORLD JOURNAL OF GASTROENTEROLOGY

MRI of Crohn’s disease: from imaging to pathology

(2011) Jordi Rimola et al.   ABDOMINAL IMAGING

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

(2011) Hyung-Ok Lee et al.   BMC CANCER

Correlation of MMP-3 and MMP-9 with Crohn’s Disease Activity in Children

(2011) Anna Kofla-Dlubacz et al.   DIGESTIVE DISEASES AND SCIENCES

Epidemiology and Natural History of Inflammatory Bowel Diseases

(2011) Jacques Cosnes et al.   GASTROENTEROLOGY

Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis

(2010) Jérôme Avouac et al.   ARTHRITIS AND RHEUMATISM

Fibroblast activation protein expression in Crohnʼs disease strictures

(2010) Laura Rovedatti et al.   INFLAMMATORY BOWEL DISEASES

Transforming growth factor   signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures

(2009) A Di Sabatino et al.   GUT

Impact of infliximab therapy after early endoscopic recurrence following ileocolonic resection of Crohnʼs disease: A prospective pilot study

(2009) Takayuki Yamamoto et al.   INFLAMMATORY BOWEL DISEASES

Small bowel resection rates in Crohnʼs disease and the indication for surgery over time: Experience from a large tertiary care center

(2009) Mark Lazarev et al.   INFLAMMATORY BOWEL DISEASES

Fibroblasts and myofibroblasts in wound healing: Force generation and measurement

(2009) Bin Li et al.   Journal of Tissue Viability

Prospective Study of Long-Term Results and Prognostic Factors After Conservative Surgery for Small Bowel Crohn's Disease

(2008) Gianluca M. Sampietro et al.   Clinical Gastroenterology and Hepatology

Infliximab Prevents Crohn's Disease Recurrence After Ileal Resection

(2008) Miguel Regueiro et al.   GASTROENTEROLOGY