PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation

(2009) Linda Slanec Higgins et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of peroxisome proliferator-activated receptor γ in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis

(2009) Mohit Kapoor et al.   ARTHRITIS AND RHEUMATISM

Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice

(2009) Adrienn Kis et al.   EUROPEAN JOURNAL OF HEART FAILURE

The role of plasminogen activator inhibitor 1 in renal and cardiovascular diseases

(2009) Hunjoo Ha et al.   Nature Reviews Nephrology

Transforming growth factor β as a therapeutic target in systemic sclerosis

(2009) John Varga et al.   Nature Reviews Rheumatology

Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts

(2009) X. Shi-wen et al.   RHEUMATOLOGY

Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis

(2009) Christian Beyer et al.   ARTHRITIS RESEARCH & THERAPY

Connective tissue growth factor inhibits adipocyte differentiation

(2008) Joanne T. M. Tan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-γ

(2008) Asish K Ghosh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological application of caffeine inhibits TGF-β-stimulated connective tissue growth factor expression in hepatocytes via PPARγ and SMAD2/3-dependent pathways

(2008) Olav A. Gressner et al.   JOURNAL OF HEPATOLOGY

Hair Follicle Stem Cell-Specific PPARγ Deletion Causes Scarring Alopecia

(2008) Pratima Karnik et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PPAR-γ agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-β

(2008) Toru Kawai et al.   LABORATORY INVESTIGATION

Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

(2008) Ausra Milano et al.   PLoS One

PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis

(2007) Jami E. Milam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY