A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization

Published 2017 View Full Article

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Title
A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization
Authors
Keywords
chimeric antigen receptor, affinity, CD38, multiple myeloma, scFV, CAR design, off-target effects
Journal
MOLECULAR THERAPY
Volume 25, Issue 8, Pages 1946-1958
Publisher
Elsevier BV
Online
2017-05-13
DOI
10.1016/j.ymthe.2017.04.024

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