Autophagy in α-Synucleinopathies—An Overstrained System

Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes

(2021) C. Alexander Boecker et al.   CURRENT BIOLOGY

Parkinson’s Disease: A Prionopathy?

(2021) Sarah Vascellari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploring the Role of Autophagy Dysfunction in Neurodegenerative Disorders

(2021) Tarapati Rana et al.   MOLECULAR NEUROBIOLOGY

Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice

(2021) Francois Singh et al.   eLife

The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?

(2021) Adina N. MacMahon Copas et al.   Frontiers in Neurology

Autophagy in Parkinson's Disease

(2020) Xu Hou et al.   JOURNAL OF MOLECULAR BIOLOGY

Synucleinphagy: a microglial “community cleanup program” for neuroprotection

(2020) Insup Choi et al.   Autophagy

A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function

(2020) Ciaran P. A. Doherty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Generation of a human induced pluripotent stem cell line derived from a Parkinson's disease patient carrying SNCA duplication

(2020) Hidefumi Suzuki et al.   Stem Cell Research

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

(2020) Insup Choi et al.   Nature Communications

Using High-Content Screening to Generate Single-Cell Gene-Corrected Patient-Derived iPS Clones Reveals Excess Alpha-Synuclein with Familial Parkinson’s Disease Point Mutation A30P

(2020) Peter Barbuti et al.   Cells

A30P mutant α-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons

(2019) Zhinian Lei et al.   Cell Death & Disease

Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines

(2019) Amanda L. Woerman et al.   ACTA NEUROPATHOLOGICA

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

(2019) Panagiota Mavroeidi et al.   ACTA NEUROPATHOLOGICA

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Autophagy dysfunction in peripheral blood mononuclear cells of Parkinson’s disease patients

(2019) Nikolaos Papagiannakis et al.   NEUROSCIENCE LETTERS

Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

(2018) Lisa Fellner et al.   BMC NEUROSCIENCE

BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic NeuronsIn Vivoand in Human Induced Pluripotent and Neural Stem Cells

(2018) Vukasin M. Jovanovic et al.   JOURNAL OF NEUROSCIENCE

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease

(2018) Yasuo Miki et al.   NEUROBIOLOGY OF AGING

Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

(2018) Briana R. De Miranda et al.   NEUROBIOLOGY OF DISEASE

Deregulation of autophagy and vesicle trafficking in Parkinson’s disease

(2018) Patricia Sheehan et al.   NEUROSCIENCE LETTERS

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

(2018) Seiji Kaji et al.   Stem Cell Reports

Mitochondrial Dysfunction and Mitophagy Defect Triggered by Heterozygous GBA Mutations

(2018) Hongyu Li et al.   Autophagy

Cerebrospinal Fluid Levels of Autophagy-related Proteins Represent Potentially Novel Biomarkers of Early-Stage Parkinson’s Disease

(2018) Jinyoung Youn et al.   Scientific Reports

Emerging Treatment Approaches for Parkinson’s Disease

(2018) Thomas B. Stoker et al.   Frontiers in Neuroscience

Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy

(2018) Giacomo Monzio Compagnoni et al.   Stem Cell Reports

Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons

(2017) Sabrina M Heman-Ackah et al.   HUMAN MOLECULAR GENETICS

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Non-motor features of Parkinson disease

(2017) Anthony H.V. Schapira et al.   NATURE REVIEWS NEUROSCIENCE

Diagnosis and management of dementia with Lewy bodies

(2017) Ian G. McKeith et al.   NEUROLOGY

α-Synuclein: Multiple System Atrophy Prions

(2017) Amanda L. Woerman et al.   Cold Spring Harbor Perspectives in Medicine

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy

(2017) Chuan-Ying Xu et al.   Frontiers in Aging Neuroscience

MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy

(2017) Elvira Valera et al.   Frontiers in Molecular Neuroscience

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7

(2016) Bao Wang et al.   Autophagy

Beclin1 and HMGB1 ameliorate the α-synuclein-mediated autophagy inhibition in PC12 cells

(2016) Kaihua Wang et al.   Diagnostic Pathology

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies

(2016) Maria Xilouri et al.   MOVEMENT DISORDERS

Glia and alpha-synuclein in neurodegeneration: A complex interaction

(2016) Dominik Brück et al.   NEUROBIOLOGY OF DISEASE

Role of Chaperone-Mediated Autophagy Dysfunctions in the Pathogenesis of Parkinson’s Disease

(2016) Gessica Sala et al.   Frontiers in Molecular Neuroscience

Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy

(2016) Sangwook Park et al.   PLoS One

Alteration of Upstream Autophagy-Related Proteins (ULK1, ULK2, Beclin1, VPS34 and AMBRA1) in Lewy Body Disease

(2015) Yasuo Miki et al.   BRAIN PATHOLOGY

Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla

(2015) E. E. Benarroch et al.   CLINICAL AUTONOMIC RESEARCH

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

(2015) Anastasia G. Henry et al.   HUMAN MOLECULAR GENETICS

Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells

(2015) Katharina Pukaß et al.   JOURNAL OF NEUROCHEMISTRY

 -Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2

(2015) L. R. Kett et al.   JOURNAL OF NEUROSCIENCE

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for  -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

(2015) F.-L. Tang et al.   JOURNAL OF NEUROSCIENCE

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease

(2015) Karen E. Murphy et al.   MOVEMENT DISORDERS

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells

(2015) L M A Oliveira et al.   Cell Death & Disease

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models

(2015) Mehdi Djelloul et al.   Stem Cell Reports

Autophagy in neuronal cells: general principles and physiological and pathological functions

(2014) Markus Damme et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein mRNA expression in oligodendrocytes in MSA

(2014) Yasmine T. Asi et al.   GLIA

Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells

(2014) Benjamin Ettle et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease

(2014) Lucilla Parnetti et al.   MOVEMENT DISORDERS

Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease

(2013) Gessica Sala et al.   BRAIN RESEARCH

Roadmap to Cellular Reprogramming – Manipulating Transcriptional Networks with DNA, RNA, Proteins and Small Molecules

(2013) P. Worsdorfer et al.   CURRENT MOLECULAR MEDICINE

Alpha-synuclein and protein degradation pathways in Parkinson's disease: A pathological feed-back loop

(2013) Marta Martinez-Vicente et al.   EXPERIMENTAL NEUROLOGY

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

(2013) Claudia Manzoni et al.   FASEB JOURNAL

Alpha-synuclein transfers from neurons to oligodendrocytes

(2013) Juan F. Reyes et al.   GLIA

Oxidative Stress Promotes Uptake, Accumulation, and Oligomerization of Extracellular α-Synuclein in Oligodendrocytes

(2013) Katharina Pukaß et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

α-Synucleinopathy phenotypes

(2013) Heather McCann et al.   PARKINSONISM & RELATED DISORDERS

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease

(2013) L Alvarez-Erviti et al.   Cell Death & Disease

Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy

(2012) Nadia Stefanova et al.   ACTA NEUROPATHOLOGICA

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

(2012) Matthew E. Gegg et al.   ANNALS OF NEUROLOGY

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Involvement of Macroautophagy in Multiple System Atrophy and Protein Aggregate Formation in Oligodendrocytes

(2012) Lisa Schwarz et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Deficiency of ATP13A2 Leads to Lysosomal Dysfunction,  -Synuclein Accumulation, and Neurotoxicity

(2012) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

(2012) L. G. Friedman et al.   JOURNAL OF NEUROSCIENCE

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

(2012) Masatoshi Konno et al.   Molecular Neurodegeneration

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Alteration of autophagosomal proteins in the brain of multiple system atrophy

(2012) Kunikazu Tanji et al.   NEUROBIOLOGY OF DISEASE

Neuronal to oligodendroglial alpha-synuclein redistribution in a double transgenic model of multiple system atrophy

(2012) Edward Rockenstein et al.   NEUROREPORT

Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies

(2012) Haya Kisos et al.   PLoS One

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

(2012) B. Dehay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in Dementias

(2011) Christine Lund Kragh et al.   BRAIN PATHOLOGY

Altered expression of autophagic genes in the peripheral leukocytes of patients with sporadic Parkinson's disease

(2011) Guanghua Wu et al.   BRAIN RESEARCH

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies

(2011) Shinji Higashi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

Glia: Initiators and progressors of pathology in Parkinson's disease

(2011) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease

(2011) Kunikazu Tanji et al.   NEUROBIOLOGY OF DISEASE

Extensive distribution of glial cytoplasmic inclusions in an autopsied case of multiple system atrophy with a prolonged 18-year clinical course

(2011) Kenta Masui et al.   NEUROPATHOLOGY

Immunohistochemical localization of aggresomal proteins in glial cytoplasmic inclusions in multiple system atrophy

(2011) Y. Chiba et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

(2011) Michael J. Devine et al.   Nature Communications

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

Single Molecule Characterization of α-Synuclein in Aggregation-Prone States

(2010) Adam J. Trexler et al.   BIOPHYSICAL JOURNAL

Cytoprotective roles for autophagy

(2010) Kevin Moreau et al.   CURRENT OPINION IN CELL BIOLOGY

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

The role of alpha-synuclein in neurotransmission and synaptic plasticity

(2010) Furong Cheng et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein

(2009) Wai Haung Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein

(2009) Sharareh Emadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy

(2009) Q. Yang et al.   SCIENCE

Multiple system atrophy: A primary oligodendrogliopathy

(2008) Gregor K. Wenning et al.   ANNALS OF NEUROLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Non-motor symptoms in Parkinson’s disease

(2008) W. Poewe   EUROPEAN JOURNAL OF NEUROLOGY

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

(2008) Marta Martinez-Vicente et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain