Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

Glia and alpha-synuclein in neurodegeneration: A complex interaction

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Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells

(2015) Katharina Pukaß et al.   JOURNAL OF NEUROCHEMISTRY

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models

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Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesis

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Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

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Oxidative stress and autophagy: the clash between damage and metabolic needs

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Alpha-synuclein mRNA expression in oligodendrocytes in MSA

(2014) Yasmine T. Asi et al.   GLIA

Towards translational therapies for multiple system atrophy

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Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration

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Alpha-synuclein and protein degradation pathways in Parkinson's disease: A pathological feed-back loop

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Alpha-synuclein transfers from neurons to oligodendrocytes

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Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy

(2012) Nadia Stefanova et al.   ACTA NEUROPATHOLOGICA

Autophagy and pancreatitis

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Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway

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Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Involvement of Macroautophagy in Multiple System Atrophy and Protein Aggregate Formation in Oligodendrocytes

(2012) Lisa Schwarz et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Role of Glia in Alpha-Synucleinopathies

(2012) Lisa Fellner et al.   MOLECULAR NEUROBIOLOGY

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

(2012) Masatoshi Konno et al.   Molecular Neurodegeneration

Alteration of autophagosomal proteins in the brain of multiple system atrophy

(2012) Kunikazu Tanji et al.   NEUROBIOLOGY OF DISEASE

Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies

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Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts

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Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

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The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Autophagic pathways in Parkinson disease and related disorders

(2011) Maria Xilouri et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

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Extensive distribution of glial cytoplasmic inclusions in an autopsied case of multiple system atrophy with a prolonged 18-year clinical course

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Neuropathology in Parkinson’s disease with mild cognitive impairment

(2010) Kurt A. Jellinger   ACTA NEUROPATHOLOGICA

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

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Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

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SNCAvariants are associated with increased risk for multiple system atrophy

(2009) Sonja W. Scholz et al.   ANNALS OF NEUROLOGY

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Genetic Variants of the α-Synuclein Gene SNCA Are Associated with Multiple System Atrophy

(2009) Ammar Al-Chalabi et al.   PLoS One

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple system atrophy: A primary oligodendrogliopathy

(2008) Gregor K. Wenning et al.   ANNALS OF NEUROLOGY

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY