Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1

(2018) Kurt A. Jellinger   JOURNAL OF ALZHEIMERS DISEASE

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death

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ELISA method to detect α-synuclein oligomers in cell and animal models

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Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents

(2018) Nicole K. Polinski et al.   Journal of Parkinsons Disease

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

(2018) Seiji Kaji et al.   Stem Cell Reports

Precise Cerebral Vascular Atlas in Stereotaxic Coordinates of Whole Mouse Brain

(2017) Benyi Xiong et al.   Frontiers in Neuroanatomy

α-Synuclein: Multiple System Atrophy Prions

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Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss

(2017) Jessica Grigoletto et al.   Acta Neuropathologica Communications

α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy

(2016) Benjamin Ettle et al.   ACTA NEUROPATHOLOGICA

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

(2016) Nolwen L. Rey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intraventricular injections of mesenchymal stem cells activate endogenous functional remyelination in a chronic demyelinating murine model

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Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells

(2015) Katharina Pukaß et al.   JOURNAL OF NEUROCHEMISTRY

The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions

(2015) Rowan Radford et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

Multiple-System Atrophy

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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

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Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases

(2015) Ronald Melki   Journal of Parkinsons Disease

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models

(2015) Mehdi Djelloul et al.   Stem Cell Reports

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

(2015) Maria E. Bernis et al.   Acta Neuropathologica Communications

Alpha-synuclein mRNA expression in oligodendrocytes in MSA

(2014) Yasmine T. Asi et al.   GLIA

Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells

(2014) Benjamin Ettle et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy

(2014) Anthony S Don et al.   Acta Neuropathologica Communications

Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy

(2014) Kiyobumi Ota et al.   Acta Neuropathologica Communications

Exploring Myelin Dysfunction in Multiple System Atrophy

(2014) Joanna H. Wong et al.   Experimental Neurobiology

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration

(2013) Maria Xilouri et al.   BRAIN

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Alpha-synuclein transfers from neurons to oligodendrocytes

(2013) Juan F. Reyes et al.   GLIA

Oxidative Stress Promotes Uptake, Accumulation, and Oligomerization of Extracellular α-Synuclein in Oligodendrocytes

(2013) Katharina Pukaß et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Conformational templating of α-synuclein aggregates in neuronal-glial cultures

(2013) Amanda N Sacino et al.   Molecular Neurodegeneration

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

(2012) Masatoshi Konno et al.   Molecular Neurodegeneration

Neuronal to oligodendroglial alpha-synuclein redistribution in a double transgenic model of multiple system atrophy

(2012) Edward Rockenstein et al.   NEUROREPORT

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo

(2012) Elodie Angot et al.   PLoS One

Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies

(2012) Haya Kisos et al.   PLoS One

Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system

(2011) Maria Xilouri et al.   HUMAN MOLECULAR GENETICS

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Pseudohyperphosphorylation Causing AD-like Changes in Tau Has Significant Effects on Its Polymerization

(2009) Qian Sun et al.   BIOCHEMISTRY

α-Synuclein Aggregation and Ser-129 Phosphorylation-dependent Cell Death in Oligodendroglial Cells

(2009) Christine L. Kragh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inducible over-expression of wild type α-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death

(2009) Kostas Vekrellis et al.   JOURNAL OF NEUROCHEMISTRY

Structural Properties of Pore-Forming Oligomers of α-Synuclein

(2009) Hai-Young Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of α-synuclein in an aggregation prone state

(2009) Min-Kyu Cho et al.   PROTEIN SCIENCE

Multiple system atrophy: A primary oligodendrogliopathy

(2008) Gregor K. Wenning et al.   ANNALS OF NEUROLOGY

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY