Comprehensive Profiling of Mammalian Tribbles Interactomes Implicates TRIB3 in Gene Repression

Tribbles homolog 2 promotes hepatic fibrosis and hepatocarcinogenesis through phosphatase 1A‐Mediated stabilization of yes‐associated protein

(2021) Dejuan Xiang et al.   LIVER INTERNATIONAL

Kinase drug discovery 20 years after imatinib: progress and future directions

(2021) Philip Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Tribbles Pseudokinase 3 Regulation and Contribution to Cancer

(2021) Bojana Stefanovska et al.   Cancers

The Critical Role of TRIB2 in Cancer and Therapy Resistance

(2021) Victor Mayoral-Varo et al.   Cancers

Tribbles Pseudokinases in Colorectal Cancer

(2021) Bibiana I. Ferreira et al.   Cancers

The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer

(2021) Alba Orea-Soufi et al.   Cancers

KIAA1217 : A novel candidate gene associated with isolated and syndromic vertebral malformations

(2020) Noura Al Dhaheri et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ

(2020) Sha Zhou et al.   ONCOGENE

A novel tumor suppressor ZBTB1 regulates tamoxifen resistance and aerobic glycolysis through suppressing HER2 expression in breast cancer

(2020) Panhong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target

(2020) Jiao-jiao Yu et al.   Nature Communications

Fatty Acid Synthase: An Emerging Target in Cancer

(2020) Chee Wai Fhu et al.   MOLECULES

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

(2020) Parastoo Shahrouzi et al.   Cancers

The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export

(2019) Jennifer E Kung et al.   EMBO JOURNAL

Pseudokinases: a tribble‐edged sword

(2019) Laura Richmond et al.   FEBS Journal

TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription

(2019) Jin-mei Yu et al.   Nature Communications

Chk1 and 14‐3‐3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest

(2018) Ruixue Yuan et al.   EMBO JOURNAL

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

(2018) Sam A. Jamieson et al.   Science Signaling

TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis

(2018) Fang Hua et al.   GASTROENTEROLOGY

Pseudokinases: update on their functions and evaluation as new drug targets

(2017) Dominic P Byrne et al.   Future Medicinal Chemistry

Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family

(2017) Aamir Ali et al.   JOURNAL OF BIOSCIENCES

Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation

(2017) Vittoria Massafra et al.   PLoS One

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1

(2017) Izabela Durzynska et al.   STRUCTURE

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

(2017) Patrick A. Eyers et al.   TRENDS IN CELL BIOLOGY

TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT

(2017) Richard Hill et al.   Nature Communications

TRIB1 Is Regulated Post-Transcriptionally by Proteasomal and Non-Proteasomal Pathways

(2016) Sébastien Soubeyrand et al.   PLoS One

Inactivation of 3-hydroxybutyrate dehydrogenase2 delays zebrafish erythroid maturation by conferring premature mitophagy

(2016) Gangarao Davuluri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing Protein–Protein Interactions Using Mass Spectrometry: Challenges and Opportunities

(2016) Arne H. Smits et al.   TRENDS IN BIOTECHNOLOGY

Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways

(2016) Hongtao Guan et al.   Scientific Reports

Tribbles at the cross-roads...

(2015) E. Kiss-Toth et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ten things you should know about protein kinases: IUPHAR Review 14

(2015) Doriano Fabbro et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRIB2 as a biomarker for diagnosis and progression of melanoma

(2015) Richard Hill et al.   CARCINOGENESIS

Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis

(2015) Xiaolong Zhuo et al.   JOURNAL OF CELL BIOLOGY

Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins

(2015) H. Yu et al.   JOURNAL OF CELL SCIENCE

Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα

(2015) Robert C. Bauer et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase

(2015) James M. Murphy et al.   STRUCTURE

Inhibition of tribbles protein-1 attenuates radioresistance in human glioma cells

(2015) Bo Tang et al.   Scientific Reports

Transcriptional Repressor ZBTB1 Promotes Chromatin Remodeling and Translesion DNA Synthesis

(2014) Hyungjin Kim et al.   MOLECULAR CELL

Drosophila Tribbles Antagonizes Insulin Signaling-Mediated Growth and Metabolism via Interactions with Akt Kinase

(2014) Rahul Das et al.   PLoS One

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

(2014) Ryan W Serra et al.   eLife

KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions

(2013) Angelo Lupo et al.   CURRENT GENOMICS

MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1

(2013) Zhuo-Yuan Lin et al.   INTERNATIONAL JOURNAL OF CANCER

Impaired Phosphorylation and Ubiquitination by p70 S6 Kinase (p70S6K) and Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promote Tribbles Homolog 2 (TRIB2) Stability and Carcinogenic Property in Liver Cancer

(2013) Jiayi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Dissection and Stoichiometry Determination of the Human SET1/MLL Histone Methyltransferase Complexes

(2013) R. van Nuland et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Uncovering the role of p53 splice variants in human malignancy: a clinical perspective

(2013) Jean-Christophe Bourdon et al.   OncoTargets and Therapy

Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess

(2012) Jiarong Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Developmental roles of tribbles protein family members

(2012) Leonard L. Dobens et al.   DEVELOPMENTAL DYNAMICS

Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation

(2011) Takashi Yokoyama et al.   CANCER SCIENCE

A Protein Complex Network of Drosophila melanogaster

(2011) K.G. Guruharsha et al.   CELL

Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE

(2011) Qingmei Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα

(2011) K B Grandinetti et al.   ONCOGENE

Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis

(2010) T. Yokoyama et al.   BLOOD

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway

(2010) Kanako Kume et al.   GENES TO CELLS

The Role of HDAC6 in Cancer

(2010) Grace I. Aldana-Masangkay et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif

(2010) Ivan Matic et al.   MOLECULAR CELL

Tribbles-1 as a Novel Biomarker of Chronic Antibody-Mediated Rejection

(2008) J. Ashton-Chess et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY