Tribbles Pseudokinase 3 Regulation and Contribution to Cancer

Rapalog-mediated repression of Tribbles pseudokinase 3 regulates pre-mRNA splicing

(2020) Bojana Stefanovska et al.   CANCER RESEARCH

Activation of Wnt/β-catenin pathway causes insulin resistance and increases lipogenesis in HepG2 cells via regulation of endoplasmic reticulum stress

(2020) Zili Lei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIB3 destabilizes tumor suppressor PPARα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia

(2020) Xu Luo et al.   LIFE SCIENCES

Excised linear introns regulate growth in yeast

(2019) Jeffrey T. Morgan et al.   NATURE

Intron RNA sequences help yeast cells to survive starvation

(2019) Samantha R. Edwards et al.   NATURE

TRB3 interacts with ERK and JNK and contributes to the proliferation, apoptosis, and migration of lung adenocarcinoma cells

(2019) Xiaopei Cao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis

(2018) Fang Hua et al.   GASTROENTEROLOGY

Intron retention as a component of regulated gene expression programs

(2017) Aishwarya G. Jacob et al.   HUMAN GENETICS

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

(2017) Patrick A. Eyers et al.   TRENDS IN CELL BIOLOGY

Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer

(2016) J Izrailit et al.   ONCOGENE

The TRIB3-SQSTM1 interaction mediates metabolic stress-promoted tumorigenesis and progression via suppressing autophagic and proteasomal degradation

(2015) Fang Hua et al.   Autophagy

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

(2015) Fiona P. Bailey et al.   BIOCHEMICAL JOURNAL

TRIB3 enhances cell viability during glucose deprivation in HEK293-derived cells by upregulating IGFBP2, a novel nutrient deficiency survival factor

(2015) Tiit Örd et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting unfolded protein response in cancer and diabetes

(2015) S. Mkrtchian   ENDOCRINE-RELATED CANCER

Smyd1 Facilitates Heart Development by Antagonizing Oxidative and ER Stress Responses

(2015) Tara L. Rasmussen et al.   PLoS One

Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase

(2015) James M. Murphy et al.   STRUCTURE

TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

(2015) Fang Hua et al.   Nature Communications

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

(2015) C. Swanton et al.   Cancer Discovery

Rapamycin-binding FKBP25 associates with diverse proteins that form large intracellular entities

(2014) Andrzej Galat et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation

(2014) M Salazar et al.   CELL DEATH AND DIFFERENTIATION

Tribbles Homolog 3 Attenuates Mammalian Target of Rapamycin Complex-2 Signaling and Inflammation in the Diabetic Kidney

(2014) E. Borsting et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TRIB3 alters endoplasmic reticulum stress-induced β-cell apoptosis via the NF-κB pathway

(2014) Ni Fang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Integrated Analysis of Copy Number Variation and Genome-Wide Expression Profiling in Colorectal Cancer Tissues

(2014) Nur Zarina Ali Hassan et al.   PLoS One

A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons

(2013) N Zareen et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity

(2013) T. Geng et al.   DIABETOLOGIA

Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer

(2013) Lenora W. M. Loo et al.   GENES CHROMOSOMES & CANCER

Knockdown of TRB3 induces apoptosis in human lung adenocarcinoma cells through regulation of Notch 1 expression

(2013) HUI ZHOU et al.   Molecular Medicine Reports

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGF  pathways as fundamental Notch regulators in breast cancer

(2013) J. Izrailit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mammalian Tribbles Homolog TRIB3, Glucose Homeostasis, and Cardiovascular Diseases

(2012) Sabrina Prudente et al.   ENDOCRINE REVIEWS

Human Tribbles 3 Protects Nuclear DNA from Cytidine Deamination by APOBEC3A

(2012) Marie-Ming Aynaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-Inducible Caspase Substrate TRB3 Promotes Nuclear Translocation of Procaspase-3

(2012) Kouhei Shimizu et al.   PLoS One

Regulation of TRIB3 mRNA and Protein in Breast Cancer

(2012) Marloes Wennemers et al.   PLoS One

TRB3 interacts with SMAD3 promoting tumor cell migration and invasion

(2011) F. Hua et al.   JOURNAL OF CELL SCIENCE

Everolimus for Advanced Pancreatic Neuroendocrine Tumors

(2011) James C. Yao et al.   NEW ENGLAND JOURNAL OF MEDICINE

TRB3 overexpression due to endoplasmic reticulum stress inhibits AKT kinase activation of tongue squamous cell carcinoma

(2011) Jing Zhang et al.   ORAL ONCOLOGY

Differential ability of Tribbles family members to promote degradation of C/EBP  and induce acute myelogenous leukemia

(2010) P. H. Dedhia et al.   BLOOD

An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-κB activation and cytokine levels

(2010) Shane P. Duggan et al.   CARCINOGENESIS

The Amiloride Derivative Phenamil Attenuates Pulmonary Vascular Remodeling by Activating NFAT and the Bone Morphogenetic Protein Signaling Pathway

(2010) M. C. Chan et al.   MOLECULAR AND CELLULAR BIOLOGY

Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance

(2009) Jiarong Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Abnormal expression of TRIB3 in colorectal cancer: a novel marker for prognosis

(2009) N Miyoshi et al.   BRITISH JOURNAL OF CANCER

E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3

(2008) Ying Zhou et al.   CELLULAR SIGNALLING

TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ transcriptional activity

(2008) Yu Takahashi et al.   JOURNAL OF LIPID RESEARCH

Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-κB and ATF4

(2008) T Rzymski et al.   ONCOGENE