Impaired Phosphorylation and Ubiquitination by p70 S6 Kinase (p70S6K) and Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promote Tribbles Homolog 2 (TRIB2) Stability and Carcinogenic Property in Liver Cancer

Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer

(2013) Jiayi Wang et al.   HEPATOLOGY

Reprogramming of the MicroRNA Transcriptome Mediates Resistance to Rapamycin

(2013) Hana Totary-Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIB2 Acts Downstream of Wnt/TCF in Liver Cancer Cells to Regulate YAP and C/EBPα Function

(2013) Jiayi Wang et al.   MOLECULAR CELL

PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies

(2013) Akio Iwanami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL

(2012) Maura M. Hannon et al.   BRITISH JOURNAL OF HAEMATOLOGY

The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing

(2012) Yu-Ling Chen et al.   JOURNAL OF PATHOLOGY

Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells

(2011) Ping Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The E3 Ligase Smurf1 Regulates Wolfram Syndrome Protein Stability at the Endoplasmic Reticulum

(2011) Xing Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα

(2011) K B Grandinetti et al.   ONCOGENE

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT

(2011) S M Soond et al.   ONCOGENE

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

(2010) K. Keeshan et al.   BLOOD

Smad Ubiquitylation Regulatory Factor 1/2 (Smurf1/2) Promotes p53 Degradation by Stabilizing the E3 Ligase MDM2

(2010) Jing Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells

(2010) F Zanella et al.   ONCOGENE

Rapamycin Response in Tumorigenic and Non-Tumorigenic Hepatic Cell Lines

(2009) Rosa H. Jimenez et al.   PLoS One

Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1

(2008) Kefeng Lu et al.   NATURE CELL BIOLOGY