DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation

DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing

(2021) Chaoyou Xue et al.   TRENDS IN GENETICS

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib

(2020) Greta Bagnolini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy

(2020) Jac A. Nickoloff et al.   Genes

Biomarker-Guided Development of DNA Repair Inhibitors

(2020) James M. Cleary et al.   MOLECULAR CELL

CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection

(2020) Ilaria Ceppi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair

(2020) Qin Zhou et al.   Nature Communications

Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining

(2020) Klaudia Szymonowicz et al.   Cells

Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination

(2020) J. Brooks Crickard et al.   CELL

The MRE11 complex: A versatile toolkit for the repair of broken DNA

(2020) Giordano Reginato et al.   DNA REPAIR

Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features

(2020) Md Fazlul Karim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining

(2020) J. A. Kamp et al.   Nature Communications

DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage

(2020) Thom G. A. Reuvers et al.   Cancers

Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells

(2020) Stefan J. Roobol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The molecular basis and disease relevance of non-homologous DNA end joining

(2020) Bailin Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylated CtIP bridges DNA to promote annealing of broken ends

(2020) Robin Öz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Determinant of DNA Repair Pathway Choices in Ionising Radiation-Induced DNA Double-Strand Breaks

(2020) Lei Zhao et al.   Biomed Research International

Carbon Ion Radiobiology

(2020) Walter Tinganelli et al.   Cancers

TRF2-independent chromosome end protection during pluripotency

(2020) Phil Ruis et al.   NATURE

Roadmap: proton therapy physics and biology

(2020) Harald Paganetti et al.   PHYSICS IN MEDICINE AND BIOLOGY

Hyperthermia: The Optimal Treatment to Overcome Radiation Resistant Hypoxia

(2019) Pernille Elming et al.   Cancers

On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation

(2019) Nathalie van den Tempel et al.   Cancers

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

(2019) Kyosuke Nakamura et al.   NATURE CELL BIOLOGY

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation

(2019) Dali Zong et al.   MOLECULAR CELL

Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage

(2019) Rachel J. Carter et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Shieldin – the protector of DNA ends

(2019) Dheva Setiaputra et al.   EMBO REPORTS

Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiation

(2019) Anne-Catherine Wéra et al.   CELL CYCLE

Relative Biological Effect/Linear Energy Transfer in Proton Beam Therapy: A Primer

(2019) S.L. Gulliford et al.   CLINICAL ONCOLOGY

The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair

(2019) Eirini Terpsi Vitti et al.   Cancers

Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death

(2019) Scott J. Bright et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Modelling variable proton relative biological effectiveness for treatment planning

(2019) Aimee McNamara et al.   BRITISH JOURNAL OF RADIOLOGY

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

(2019) Elsa Callen et al.   MOLECULAR CELL

Genetic determinants of cellular addiction to DNA polymerase theta

(2019) Wanjuan Feng et al.   Nature Communications

MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

(2019) Israel Salguero et al.   Nature Communications

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

(2019) Jacqueline H. L. Fok et al.   Nature Communications

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

(2019) Frederick W. Goldberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52

(2019) Emil Mladenov et al.   NUCLEIC ACIDS RESEARCH

BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

(2018) Chaoyang Sun et al.   CANCER CELL

H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2

(2018) Marco Simonetta et al.   CELL CYCLE

Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response

(2018) Rachel J. Carter et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Repair of DNA double-strand breaks by mammalian alternative end-joining pathways

(2018) Annahita Sallmyr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homologous recombination and the repair of DNA double-strand breaks

(2018) William Douglass Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microhomology-mediated end joining: Good, bad and ugly

(2018) Ja-Hwan Seol et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions

(2018) Nadish Goyal et al.   Nature Communications

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells

(2018) Marco Barazas et al.   Cell Reports

Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest

(2018) José Reyes et al.   MOLECULAR CELL

53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

(2018) Zachary Mirman et al.   NATURE

Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture

(2018) Sara Timm et al.   RADIOTHERAPY AND ONCOLOGY

Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons

(2018) Sebastian Oeck et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Report of a National Cancer Institute special panel: Characterization of the physical parameters of particle beams for biological research

(2018) Marco Durante et al.   MEDICAL PHYSICS

State-of-the-art strategies for targeting the DNA damage response in cancer

(2018) Patrick G. Pilié et al.   Nature Reviews Clinical Oncology

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Damage in Stem Cells

(2017) Ilio Vitale et al.   MOLECULAR CELL

The control of DNA repair by the cell cycle

(2017) Nicole Hustedt et al.   NATURE CELL BIOLOGY

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of the elementary structural units of the DNA damage response

(2017) Francesco Natale et al.   Nature Communications

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination

(2017) Nathalie van den Tempel et al.   Oncotarget

Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP

(2017) James M. Daley et al.   Cell Reports

BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation

(2017) Mayu Isono et al.   Cell Reports

Particles with similar LET values generate DNA breaks of different complexity and reparability: a high-resolution microscopy analysis of γH2AX/53BP1 foci

(2017) Lucie Jezkova et al.   Nanoscale

A novel small molecule inhibitor of the DNA repair protein Ku70/80

(2016) Eric Weterings et al.   DNA REPAIR

Superresolution light microscopy shows nanostructure of carbon ion radiation-induced DNA double-strand break repair foci

(2016) Ramon Lopez Perez et al.   FASEB JOURNAL

The In Vitro Response of Tissue Stem Cells to Irradiation With Different Linear Energy Transfers

(2016) Peter W. Nagle et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection

(2016) Roopesh Anand et al.   MOLECULAR CELL

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair

(2016) Shuren Liao et al.   NUCLEIC ACIDS RESEARCH

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation

(2016) A. Kanakkanthara et al.   SCIENCE

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Potentiation of Peptide Receptor Radionuclide Therapy by the PARP Inhibitor Olaparib

(2016) Julie Nonnekens et al.   Theranostics

Nanoscale analysis of clustered DNA damage after high-LET irradiation by quantitative electron microscopy – The heavy burden to repair

(2015) Yvonne Lorat et al.   DNA REPAIR

The Ku heterodimer: Function in DNA repair and beyond

(2015) Victoria L. Fell et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

The physics of proton therapy

(2015) Wayne D Newhauser et al.   PHYSICS IN MEDICINE AND BIOLOGY

Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells

(2015) Hongyu Ma et al.   Radiation Oncology

The Major DNA Repair Pathway after Both Proton and Carbon-Ion Radiation is NHEJ, but the HR Pathway is More Relevant in Carbon Ions

(2015) Ariungerel Gerelchuluun et al.   RADIATION RESEARCH

Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation

(2015) Andrea O. Fontana et al.   RADIOTHERAPY AND ONCOLOGY

DNA end resection is needed for the repair of complex lesions in G1-phase human cells

(2014) Nicole B Averbeck et al.   CELL CYCLE

BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells

(2014) Marcel Reuter et al.   JOURNAL OF CELL BIOLOGY

Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer

(2014) Harald Paganetti   PHYSICS IN MEDICINE AND BIOLOGY

A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

(2014) Fei Huang et al.   PLoS One

The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold

(2013) Alexander Loewer et al.   BMC BIOLOGY

The complexity of DNA double strand breaks is a critical factor enhancing end-resection

(2013) Hirohiko Yajima et al.   DNA REPAIR

Deficiency in Homologous Recombination Renders Mammalian Cells More Sensitive to Proton Versus Photon Irradiation

(2013) Nicole Grosse et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Double strand break repair functions of histone H2AX

(2013) Ralph Scully et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction and Repair of Clustered DNA Lesions: What Do We Know So Far?

(2013) Alexandros G. Georgakilas et al.   RADIATION RESEARCH

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

(2013) Hailong Wang et al.   PLoS Genetics

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining

(2012) Judith W.J. Bergs et al.   DNA REPAIR

Inhibition of Homologous Recombination in Human Cells by Targeting RAD51 Recombinase

(2012) Fei Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modelling of the oxygen enhancement ratio for ion beam radiation therapy

(2011) Tatiana Wenzl et al.   PHYSICS IN MEDICINE AND BIOLOGY

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

(2011) P. M. Krawczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks

(2010) Elisia D. Tichy et al.   STEM CELLS AND DEVELOPMENT

Tumor Hypoxia as a Modifier of DNA Strand Break and Cross-Link Repair

(2009) Norman Chan et al.   CURRENT MOLECULAR MEDICINE

Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance

(2008) N. Chan et al.   CANCER RESEARCH

Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks

(2008) C.A. Bañuelos et al.   DNA REPAIR

Quality control of DNA break metabolism: in the ‘end’, it's a good thing

(2008) Roland Kanaar et al.   EMBO JOURNAL

Human Embryonic Stem Cells Have Enhanced Repair of Multiple Forms of DNA Damage

(2008) Scott Maynard et al.   STEM CELLS