The Determinant of DNA Repair Pathway Choices in Ionising Radiation-Induced DNA Double-Strand Breaks

Generalized Multi-Hit Model of Radiation-Induced Cell Survival with a Closed-Form Solution: An Alternative Method for Determining Isoeffect Doses in Practical Radiotherapy

(2020) Lei Zhao et al.   RADIATION RESEARCH

A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair

(2019) Eva Bártová et al.   Aging-US

Shieldin – the protector of DNA ends

(2019) Dheva Setiaputra et al.   EMBO REPORTS

The role of RNA and RNA-related proteins in the regulation of DNA double strand break repair pathway choice

(2019) Sonia Jimeno et al.   DNA REPAIR

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Life or Death after a Break: What Determines the Choice?

(2019) Lenno Krenning et al.   MOLECULAR CELL

The DNA damage response to transcription stress

(2019) Hannes Lans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fitting the Generalized Target Model to Cell Survival Data of Proton Radiation Reveals Dose-Dependent RBE and Inspires an Alternative Method to Estimate RBE in High-Dose Regions

(2019) Lei Zhao et al.   RADIATION RESEARCH

The Role of Noncoding RNAs in Double-Strand Break Repair

(2019) Nathalie Durut et al.   Frontiers in Plant Science

Nanoscopic analysis of 53BP1, BRCA1 and Rad51 reveals new insights in temporal progression of DNA-repair and pathway choice

(2019) Benjamin Schwarz et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer

(2019) George Iliakis et al.   Cancers

A Mechanism to Minimize Errors during Non-homologous End Joining

(2019) Benjamin M. Stinson et al.   MOLECULAR CELL

Identification of potential radiation-responsive biomarkers based on human orthologous genes with possible roles in DNA repair pathways by comparison between Arabidopsis thaliana and homo sapiens

(2019) Lei Zhao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

(2018) Rajat Gupta et al.   CELL

Repeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements

(2018) Carlos Mendez-Dorantes et al.   GENES & DEVELOPMENT

Repair of DNA double-strand breaks by mammalian alternative end-joining pathways

(2018) Annahita Sallmyr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How cells ensure correct repair of DNA double-strand breaks

(2018) Joonyoung Her et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic View and Genetic Control of DNA Recombination during Meiosis

(2018) Marie-Claude Marsolier-Kergoat et al.   MOLECULAR CELL

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

(2018) Harveer Dev et al.   NATURE CELL BIOLOGY

Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

(2018) Takaaki Yasuhara et al.   CELL

A novel multitarget model of radiation-induced cell killing based on the Gaussian distribution

(2017) Lei Zhao et al.   JOURNAL OF THEORETICAL BIOLOGY

Regulation of repair pathway choice at two-ended DNA double-strand breaks

(2017) Atsushi Shibata   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The control of DNA repair by the cell cycle

(2017) Nicole Hustedt et al.   NATURE CELL BIOLOGY

Charged-particle therapy in cancer: clinical uses and future perspectives

(2017) Marco Durante et al.   Nature Reviews Clinical Oncology

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual loss of human POLQ and LIG4 abolishes random integration

(2017) Shinta Saito et al.   Nature Communications

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bridging Plant and Human Radiation Response and DNA Repair through an In Silico Approach

(2017) Zacharenia Nikitaki et al.   Cancers

Chromatin organization revealed by nanostructure of irradiation induced γH2AX, 53BP1 and Rad51 foci

(2017) Judith Reindl et al.   Scientific Reports

Specialization of CDK regulation under DNA damage

(2016) Annika K. Weimer et al.   CELL CYCLE

Nuclear compartmentalization of DNA repair

(2016) Alkmini Kalousi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Radiosensitivity and relative biological effectiveness based on a generalized target model

(2016) Lei Zhao et al.   JOURNAL OF RADIATION RESEARCH

Two-Stage Synapsis of DNA Ends during Non-homologous End Joining

(2016) Thomas G.W. Graham et al.   MOLECULAR CELL

A role for human homologous recombination factors in suppressing microhomology-mediated end joining

(2016) Sara Ahrabi et al.   NUCLEIC ACIDS RESEARCH

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Understanding Cancer Development Processes after HZE-Particle Exposure: Roles of ROS, DNA Damage Repair and Inflammation

(2015) D. M. Sridharan et al.   RADIATION RESEARCH

A generalized target theory and its applications

(2015) Lei Zhao et al.   Scientific Reports

Nuclear position dictates DNA repair pathway choice

(2014) Charlène Lemaître et al.   GENES & DEVELOPMENT

Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

(2014) Hind Ghezraoui et al.   MOLECULAR CELL

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

(2014) Nozomi Tomimatsu et al.   Nature Communications

Ionizing Radiation-Induced DNA Damage, Response, and Repair

(2013) Wil L. Santivasi et al.   ANTIOXIDANTS & REDOX SIGNALING

Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation

(2013) Janapriya Saha et al.   DNA REPAIR

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice

(2013) A. Schipler et al.   NUCLEIC ACIDS RESEARCH

The Efficiency of Homologous Recombination and Non-Homologous End Joining Systems in Repairing Double-Strand Breaks during Cell Cycle Progression

(2013) Leonardo Bee et al.   PLoS One

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up

(2013) Julien Vignard et al.   RADIOTHERAPY AND ONCOLOGY

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

(2012) J. R. Chapman et al.   JOURNAL OF CELL SCIENCE

Increased Artemis levels confer radioresistance to both high and low LET radiation exposures

(2012) Deepa M Sridharan et al.   Radiation Oncology

Modeling Cell Survival after Photon Irradiation Based on Double-Strand Break Clustering in Megabase Pair Chromatin Loops

(2012) Thomas Friedrich et al.   RADIATION RESEARCH

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

(2011) Edouard I. Azzam et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

(2011) A. Asaithamby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heavy-ion tumor therapy: Physical and radiobiological benefits

(2010) Dieter Schardt et al.   REVIEWS OF MODERN PHYSICS

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Cellular responses to DNA double-strand breaks after low-dose γ-irradiation

(2009) Aroumougame Asaithamby et al.   NUCLEIC ACIDS RESEARCH

Homologous Recombination Contributes to the Repair of DNA Double-Strand Breaks Induced by High-Energy Iron Ions

(2009) Faria Zafar et al.   RADIATION RESEARCH

The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation

(2008) Hongyan Wang et al.   DNA REPAIR

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes

(2008) E. Rothenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA