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Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223

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Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52

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Live Dynamics of 53BP1 Foci Following Simultaneous Induction of Clustered and Dispersed DNA Damage in U2OS Cells

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Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response

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Fluorescent nuclear track detectors for alpha radiation microdosimetry

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Defining the Damaged DNA Mobility Paradox as Revealed by the Study of Telomeres, DSBs, Microtubules and Motors

(2018) Karim Mekhail   Frontiers in Genetics

Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture

(2018) Sara Timm et al.   RADIOTHERAPY AND ONCOLOGY

Around and beyond 53BP1 Nuclear Bodies

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Multi-scale tracking reveals scale-dependent chromatin dynamics after DNA damage

(2017) Judith Miné-Hattab et al.   MOLECULAR BIOLOGY OF THE CELL

A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis

(2017) Markus Löbrich et al.   TRENDS IN BIOCHEMICAL SCIENCES

3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation

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Particles with similar LET values generate DNA breaks of different complexity and reparability: a high-resolution microscopy analysis of γH2AX/53BP1 foci

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Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET)

(2016) Zacharenia Nikitaki et al.   FREE RADICAL RESEARCH

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy transfer irradiation

(2016) Yvonne Lorat et al.   RADIOTHERAPY AND ONCOLOGY

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

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DNA Double-strand Break Repair in a Cellular Context

(2014) A. Shibata et al.   CLINICAL ONCOLOGY

TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO–IKK supramolecular structures

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Every laboratory with a fluorescence microscope should consider counting molecules

(2014) Valerie C. Coffman et al.   MOLECULAR BIOLOGY OF THE CELL

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

Double-strand break repair: 53BP1 comes into focus

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PCNA is efficiently loaded on the DNA recombination intermediate to modulate polymerase  ,  , and   activities

(2013) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

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Chromatin mobility is increased at sites of DNA double-strand breaks

(2012) P. M. Krawczyk et al.   JOURNAL OF CELL SCIENCE

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

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Unrepaired clustered DNA lesions induce chromosome breakage in human cells

(2011) A. Asaithamby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells

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The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

(2010) Aaron A. Goodarzi et al.   DNA REPAIR

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation

(2010) Aroumougame Asaithamby et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Delayed repair of radiation induced clustered DNA damage: Friend or foe?

(2010) Laura J. Eccles et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

(2010) Angela T. Noon et al.   NATURE CELL BIOLOGY

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Live cell imaging and systems biology

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The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Live cell microscopy analysis of radiation-induced DNA double-strand break motion

(2009) B. Jakob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of Clustered DNA Damage after High-LET Irradiation: A Review

(2008) Megumi HADA et al.   JOURNAL OF RADIATION RESEARCH