The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair

Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage

(2019) Rachel J. Carter et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes

(2018) Lepakshi Ranjha et al.   CHROMOSOMA

Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response

(2018) Rachel J. Carter et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Toward A variable RBE for proton beam therapy

(2018) Henning Willers et al.   RADIOTHERAPY AND ONCOLOGY

Determination of the proton RBE in the rat spinal cord: Is there an increase towards the end of the spread-out Bragg peak?

(2018) Maria Saager et al.   RADIOTHERAPY AND ONCOLOGY

In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density

(2018) N. T. Henthorn et al.   Scientific Reports

Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons

(2018) Sebastian Oeck et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Radiation-induced clustered DNA lesions: Repair and mutagenesis

(2017) Evelyne Sage et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis

(2017) Ifigeneia Mavragani et al.   Cancers

Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions

(2016) Otilija D Keta et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Variations in the Processing of DNA Double-Strand Breaks Along 60-MeV Therapeutic Proton Beams

(2016) Pankaj Chaudhary et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Base Excision Repair, a Pathway Regulated by Posttranslational Modifications

(2016) Rachel J. Carter et al.   MOLECULAR AND CELLULAR BIOLOGY

Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing Radiation

(2016) Xurui Zhang et al.   PLoS One

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

(2016) Jessica S. Brown et al.   Cancer Discovery

Calculating Variations in Biological Effectiveness for a 62 MeV Proton Beam

(2016) Mario Pietro Carante et al.   Frontiers in Oncology

Lung Cancer Cell Line Screen Links Fanconi Anemia/BRCA Pathway Defects to Increased Relative Biological Effectiveness of Proton Radiation

(2015) Qi Liu et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The physics of proton therapy

(2015) Wayne D Newhauser et al.   PHYSICS IN MEDICINE AND BIOLOGY

The Major DNA Repair Pathway after Both Proton and Carbon-Ion Radiation is NHEJ, but the HR Pathway is More Relevant in Carbon Ions

(2015) Ariungerel Gerelchuluun et al.   RADIATION RESEARCH

Spectrum of Radiation-Induced Clustered Non-DSB Damage – A Monte Carlo Track Structure Modeling and Calculations

(2015) Ritsuko Watanabe et al.   RADIATION RESEARCH

Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation

(2015) Andrea O. Fontana et al.   RADIOTHERAPY AND ONCOLOGY

Proton beam radiation induces DNA damage and cell apoptosis in glioma stem cells through reactive oxygen species

(2015) R. Alan Mitteer et al.   Scientific Reports

Proton Radiobiology

(2015) Francesco Tommasino et al.   Cancers

Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment

(2014) Pankaj Chaudhary et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Enhanced radiobiological effects at the distal end of a clinical proton beam: in vitro study

(2014) Yoshitaka Matsumoto et al.   JOURNAL OF RADIATION RESEARCH

Direct evaluation of radiobiological parameters from clinical data in the case of ion beam therapy: an alternative approach to the relative biological effectiveness

(2014) A Cometto et al.   PHYSICS IN MEDICINE AND BIOLOGY

Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer

(2014) Harald Paganetti   PHYSICS IN MEDICINE AND BIOLOGY

The Effects of Ultra-High Dose Rate Proton Irradiation on Growth Delay in the Treatment of Human Tumor Xenografts in Nude Mice

(2014) O. Zlobinskaya et al.   RADIATION RESEARCH

Biological Consequences of Radiation-induced DNA Damage: Relevance to Radiotherapy

(2013) M.E. Lomax et al.   CLINICAL ONCOLOGY

Induction and Persistence of Large γH2AX Foci by High Linear Energy Transfer Radiation in DNA-Dependent protein kinase–Deficient Cells

(2013) Candelaria Bracalente et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Deficiency in Homologous Recombination Renders Mammalian Cells More Sensitive to Proton Versus Photon Irradiation

(2013) Nicole Grosse et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Therapy-Resistant Cancer Stem Cells Have Differing Sensitivity to Photon versus Proton Beam Radiation

(2013) Xiaochun Zhang et al.   Journal of Thoracic Oncology

Charged particle therapy—optimization, challenges and future directions

(2013) Jay S. Loeffler et al.   Nature Reviews Clinical Oncology

Biological Effects of Proton Radiation: What We Know and Don't Know

(2013) Swati Girdhani et al.   RADIATION RESEARCH

Induction and Repair of Clustered DNA Lesions: What Do We Know So Far?

(2013) Alexandros G. Georgakilas et al.   RADIATION RESEARCH

Biological Considerations When Comparing Proton Therapy With Photon Therapy

(2013) Harald Paganetti et al.   SEMINARS IN RADIATION ONCOLOGY

Variations in the RBE for Cell Killing Along the Depth-Dose Profile of a Modulated Proton Therapy Beam

(2012) Richard. A. Britten et al.   RADIATION RESEARCH

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

(2011) Zhiyong Mao et al.   CELL CYCLE

Simulation of DNA damage clustering after proton irradiation using an adapted DBSCAN algorithm

(2011) Ziad Francis et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

(2011) A. Asaithamby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of in situ DNA double-strand breaks and apoptosis by 200 MeV protons and 10 MV X-rays in human tumour cell lines

(2010) Ariungerel Gerelchuluun et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Radiobiological Characterization of Two Therapeutic Proton Beams With Different Initial Energy Spectra Used at the Institut Curie Proton Therapy Center in Orsay

(2010) Valentin Calugaru et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Delayed repair of radiation induced clustered DNA damage: Friend or foe?

(2010) Laura J. Eccles et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Clustered DNA lesion repair in eukaryotes: Relevance to mutagenesis and cell survival

(2010) Evelyne Sage et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Charged particles in radiation oncology

(2009) Marco Durante et al.   Nature Reviews Clinical Oncology