Anaemia, iron homeostasis and pulmonary hypertension: a review

Iron replacement in inflammatory bowel diseases: an evolving scenario

(2019) Fabiana Busti et al.   Internal and Emergency Medicine

Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice

(2019) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rats with Human Mutation of NFU1 Develop Pulmonary Hypertension

(2019) Maki Niihori et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

(2018) Yuichi Tamura et al.   JOURNAL OF CLINICAL INVESTIGATION

The crucial impact of iron deficiency definition for the course of precapillary pulmonary hypertension

(2018) Thomas Sonnweber et al.   PLoS One

The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells

(2018) Latha Ramakrishnan et al.   Scientific Reports

Anemia of inflammation

(2018) Guenter Weiss et al.   BLOOD

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

(2018) Marc Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Clinical management of iron deficiency anemia in adults: Systemic review on advances in diagnosis and treatment

(2017) Lucia De Franceschi et al.   European Journal of Internal Medicine

Iron Deficiency in COPD Associates with Increased Pulmonary Artery Pressure Estimated by Echocardiography

(2017) Louis L. Plesner et al.   Heart Lung and Circulation

Dietary iron loading negatively affects liver mitochondrial function

(2017) Chiara Volani et al.   Metallomics

“Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels

(2017) Manfred Nairz et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genetics of Pulmonary Arterial Hypertension

(2017) Joshua Chew et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

(2017) Liam A. Hurst et al.   Nature Communications

Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study

(2017) Christopher J Rhodes et al.   Lancet Respiratory Medicine

Global Pulmonary Vascular Remodeling in Pulmonary Hypertension Associated With Heart Failure and Preserved or Reduced Ejection Fraction

(2017) Ahmed U. Fayyaz et al.   CIRCULATION

A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension

(2016) Lai-Ming Yung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hepcidin in the diagnosis of iron disorders

(2016) D. Girelli et al.   BLOOD

Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2αCLINICAL PERSPECTIVE

(2016) Zhiyu Dai et al.   CIRCULATION

Reduction in mitochondrial iron alleviates cardiac damage during injury

(2016) H.-C. Chang et al.   EMBO Molecular Medicine

Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension

(2016) Aurélien Parpaleix et al.   EUROPEAN RESPIRATORY JOURNAL

Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension

(2016) Christophe Guignabert et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical iron deficiency disturbs normal human responses to hypoxia

(2016) Matthew C. Frise et al.   JOURNAL OF CLINICAL INVESTIGATION

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

(2016) Samira Lakhal-Littleton et al.   eLife

A global view of pulmonary hypertension

(2016) Marius M Hoeper et al.   Lancet Respiratory Medicine

Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex

(2015) Morane Le Hiress et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine

(2015) T. Bishop et al.   CIRCULATION RESEARCH

The Iron age of host-microbe interactions

(2015) M. P. Soares et al.   EMBO REPORTS

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension

(2015) Takahiro Hashimoto-Kataoka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anemia of Chronic Disorders: New Diagnostic Tools and New Treatment Strategies

(2015) Guenter Weiss   SEMINARS IN HEMATOLOGY

Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans

(2015) Thomas C. Darton et al.   PLoS Neglected Tropical Diseases

Intravenous Iron Therapy in Patients with Idiopathic Pulmonary Arterial Hypertension and Iron Deficiency

(2015) Gerrina Ruiter et al.   Pulmonary Circulation

Immune Dysregulation and Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2014) Alice Huertas et al.   CIRCULATION

Microvascular disease in chronic thromboembolic pulmonary hypertension: a role for pulmonary veins and systemic vasculature

(2014) P. Dorfmuller et al.   EUROPEAN RESPIRATORY JOURNAL

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

(2014) Thomas Sonnweber et al.   GUT

Ferric carboxymaltose improves exercise capacity and quality of life in patients with pulmonary arterial hypertension and iron deficiency: A pilot study

(2014) Thomas Viethen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension

(2014) Hirofumi Sawada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

A systematic analysis of global anemia burden from 1990 to 2010

(2013) N. J. Kassebaum et al.   BLOOD

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

Prevalence and Risk Factors for Pulmonary Arterial Hypertension in a Large Group of β-Thalassemia Patients Using Right Heart Catheterization

(2013) Giorgio Derchi et al.   CIRCULATION

The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: Insights into the potential of various iron therapies to induce oxidative and nitrosative stress

(2013) Taija S. Koskenkorva-Frank et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron Deficiency in Patients With Idiopathic Pulmonary Arterial Hypertension

(2013) Vanessa P.M. van Empel et al.   Heart Lung and Circulation

Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension

(2013) G. Ruiter et al.   RHEUMATOLOGY

Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia

(2012) David B. Bregman et al.   AMERICAN JOURNAL OF HEMATOLOGY

Iron Deficiency: What Are the Future Trends in Diagnostics and Therapeutics?

(2012) C. Brugnara et al.   CLINICAL CHEMISTRY

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

(2012) Qingdu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

High Levels of Zinc-Protoporphyrin Identify Iron Metabolic Abnormalities in Pulmonary Arterial Hypertension

(2011) Ilka Decker et al.   CTS-Clinical and Translational Science

Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo

(2011) I. Theurl et al.   HAEMATOLOGICA

Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension

(2011) Christopher J. Rhodes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension

(2011) E. Soon et al.   THORAX

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

(2010) Stephen L. Archer et al.   CIRCULATION

Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

(2010) Elaine Soon et al.   CIRCULATION

Iron deficiency is common in idiopathic pulmonary arterial hypertension

(2010) G. Ruiter et al.   EUROPEAN RESPIRATORY JOURNAL

Impact of iron treatment on immune effector function and cellular iron status of circulating monocytes in dialysis patients

(2010) T. Sonnweber et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review

(2009) G. Kovacs et al.   EUROPEAN RESPIRATORY JOURNAL

Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension

(2009) Thomas G. Smith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency

(2009) Stefan D. Anker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Pulmonary Hypertension

(2008) Christopher F. Barnett et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

(2008) Thomas G. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON