Involvement of cytosolic and mitochondrial iron in iron overload cardiomyopathy: an update

Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice

(2017) Juthamas Khamseekaew et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cardiac complications in beta-thalassemia: From mice to men

(2017) Sirinart Kumfu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A combination of an iron chelator with an antioxidant exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice

(2017) Sirinart Kumfu et al.   FREE RADICAL RESEARCH

Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress

(2017) Subhash K. Das et al.   Journal of the American Heart Association

Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine

(2017) Suwakon Wongjaikam et al.   Scientific Reports

Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia

(2017) Laurence H. Jackson et al.   Scientific Reports

Longitudinal changes of endocrine and bone disease in adults with β-thalassemia major receiving different iron chelators over 5 years

(2016) Maurizio Poggi et al.   ANNALS OF HEMATOLOGY

Getting to the “Heart” of Cardiac Disease by Decreasing Mitochondrial Iron

(2016) Hsiang-Chun Chang et al.   CIRCULATION RESEARCH

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia

(2016) S. Chiang et al.   CLINICAL SCIENCE

Reduction in mitochondrial iron alleviates cardiac damage during injury

(2016) H.-C. Chang et al.   EMBO Molecular Medicine

Dual T-type and L-type calcium channel blocker exerts beneficial effects in attenuating cardiovascular dysfunction in iron-overloaded thalassaemic mice

(2016) Sirinart Kumfu et al.   EXPERIMENTAL PHYSIOLOGY

In vivo behavior of NTBI revealed by automated quantification system

(2016) Satoshi Ito et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors

(2016) Adisak Tantiworawit et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Clinical Experience With Deferiprone Treatment for Friedreich Ataxia

(2016) Sandra Elincx-Benizri et al.   JOURNAL OF CHILD NEUROLOGY

Early Cardiac Involvement and Risk Factors for the Development of Arrhythmia in Patients With β-Thalassemia Major

(2016) Ahmad A. Hamed et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload

(2016) Jirapas Sripetchwandee et al.   NEUROSCIENCE

Severe cardiac iron toxicity in two adults with sickle cell disease

(2016) Hellen Oduor et al.   TRANSFUSION

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

(2016) Samira Lakhal-Littleton et al.   eLife

Combined Iron Chelator and Antioxidant Exerted Greater Efficacy on Cardioprotection Than Monotherapy in Iron-Overloaded Rats

(2016) Suwakon Wongjaikam et al.   PLoS One

Heart Rate Variability for Early Detection of Cardiac Iron Deposition in Patients with Transfusion-Dependent Thalassemia

(2016) Suchaya Silvilairat et al.   PLoS One

A 5-year follow-up in deferasirox treatment: improvement of cardiac and hepatic iron overload and amelioration in cardiac function in thalassemia major patients

(2015) E. Cassinerio et al.   ANNALS OF HEMATOLOGY

Experimental animal model to study iron overload and iron chelation and review of other such models

(2015) Khushnooma Italia et al.   BLOOD CELLS MOLECULES AND DISEASES

Current and future treatment strategies for iron overload cardiomyopathy

(2015) Suwakon Wongjaikam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Iron and oxidative stress in cardiomyopathy in thalassemia

(2015) Vasilios Berdoukas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic iron overload in rats increases vascular reactivity by increasing oxidative stress and reducing nitric oxide bioavailability

(2015) Vinicius Bermond Marques et al.   LIFE SCIENCES

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy

(2015) Subhash K. Das et al.   Scientific Reports

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

(2015) Wenjing Xu et al.   Cell Reports

Mitoferrin-2 (MFRN2) Regulates the Electrogenic Mitochondrial Calcium Uniporter and Interacts Physically with MCU

(2015) Anna-Liisa Nieminen et al.   BIOPHYSICAL JOURNAL

Heart Rate Variability as an Alternative Indicator for Identifying Cardiac Iron Status in Non-Transfusion Dependent Thalassemia Patients

(2015) Karn Wijarnpreecha et al.   PLoS One

Continuing Treatment with Salvia miltiorrhiza Injection Attenuates Myocardial Fibrosis in Chronic Iron-Overloaded Mice

(2015) Ying Zhang et al.   PLoS One

A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in  -thalassemia major (CORDELIA)

(2014) D. J. Pennell et al.   BLOOD

mRNA regulation of cardiac iron transporters and ferritin subunits in a mouse model of iron overload

(2014) Casey J. Brewer et al.   EXPERIMENTAL HEMATOLOGY

The Pathophysiology of Transfusional Iron Overload

(2014) John B. Porter et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron

(2014) Tomáš Šimůnek et al.   Pharmacological Reports

Combined Therapy of Iron Chelator and Antioxidant Completely Restores Brain Dysfunction Induced by Iron Toxicity

(2014) Jirapas Sripetchwandee et al.   PLoS One

The role of iron in anthracycline cardiotoxicity

(2014) Elena Gammella et al.   Frontiers in Pharmacology

Blockade of mitochondrial calcium uniporter prevents cardiac mitochondrial dysfunction caused by iron overload

(2013) J. Sripetchwandee et al.   Acta Physiologica

Amlodipine Reduces Cardiac Iron Overload in Patients with Thalassemia Major: A Pilot Trial

(2013) Juliano Lara Fernandes et al.   AMERICAN JOURNAL OF MEDICINE

Sustained Ventricular Tachycardia in a Patient with Thalassemia Major

(2013) Nermin Bayar et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice

(2013) Chia-Yu Wang et al.   HEPATOLOGY

Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload

(2013) Jirapas Sripetchwandee et al.   LIFE SCIENCES

Verapamil reverses cardiac iron overload in streptozocin-induced diabetic rats

(2013) Hong-li Shan et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Sex differences and steroid modulation of cardiac iron in a mouse model of iron overload

(2013) Casey Brewer et al.   Translational Research

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

(2013) Virapong Prachayasittikul et al.   Drug Design Development and Therapy

Downregulation of vitamin C transporter SVCT-2 in doxorubicin-induced cardiomyocyte injury

(2012) Ana R. Ludke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial calcium uniporter blocker prevents cardiac mitochondrial dysfunction induced by iron overload in thalassemic mice

(2012) Sirinart Kumfu et al.   BIOMETALS

How I treat transfusional iron overload

(2012) A. V. Hoffbrand et al.   BLOOD

Ferric iron uptake into cardiomyocytes of β-thalassemic mice is not through calcium channels

(2012) Sirinart Kumfu et al.   DRUG AND CHEMICAL TOXICOLOGY

T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice

(2012) Sirinart Kumfu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export

(2012) Y. Ichikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron Overload Cardiomyopathy in Clinical Practice

(2011) Dimitrios T. Kremastinos et al.   CIRCULATION

Iron Overload Decreases Ca V 1.3-Dependent L-Type Ca 2+ Currents Leading to Bradycardia, Altered Electrical Conduction, and Atrial Fibrillation

(2011) Robert A. Rose et al.   Circulation-Arrhythmia and Electrophysiology

Establishment of Secondary Iron Overloaded Mouse Model: Evaluation of Cardiac Function and Analysis According to Iron Concentration

(2011) Se Na Moon et al.   PEDIATRIC CARDIOLOGY

Deferasirox-current knowledge and future challenges

(2010) John B. Porter   Annals of the New York Academy of Sciences

Deferiprone

(2010) Antonio Piga et al.   Annals of the New York Academy of Sciences

Pathogenesis and management of iron toxicity in thalassemia

(2010) Chaim Hershko   Annals of the New York Academy of Sciences

Monitoring the efficiency of iron chelation therapy: the potential of nontransferrin-bound iron

(2010) R.C. Hider et al.   Annals of the New York Academy of Sciences

Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich’s Ataxia

(2010) Daniel Velasco-Sánchez et al.   CEREBELLUM

T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice

(2010) Sirinart Kumfu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Deferasirox, deferiprone and desferrioxamine treatment in thalassemia major patients: cardiac iron and function comparison determined by quantitative magnetic resonance imaging

(2010) A. Pepe et al.   HAEMATOLOGICA

Novel mechanism of fetal hepatocyte injury in congenital alloimmune hepatitis involves the terminal complement cascade

(2010) Xiaomin Pan et al.   HEPATOLOGY

Electrocardiographic markers for the early detection of cardiac disease in patients with beta-thalassemia major

(2010) Kemal Nisli et al.   Jornal de Pediatria

Reversal of Cardiac Iron Loading and Dysfunction in Thalassemic Mice by Curcuminoids

(2010) C. Thephinlap et al.   Medicinal Chemistry

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interdependence of cardiac iron and calcium in a murine model of iron overload

(2010) Maya Otto-Duessel et al.   Translational Research

Efficacy of deferasirox in reducing and preventing cardiac iron overload in  -thalassemia

(2009) D. J. Pennell et al.   BLOOD

A Case of Iron Overload Cardiomyopathy

(2009) Kazuro Sugishita et al.   International Heart Journal

High nontransferrin bound iron levels and heart disease in thalassemia major

(2008) Antonio Piga et al.   AMERICAN JOURNAL OF HEMATOLOGY

Ventricular late potentials among thalassemia patients

(2008) Hussain Isma'eel et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Vitamins E and C in the Prevention of Cardiovascular Disease in Men

(2008) Howard D. Sesso   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mitochondrial DNA Damage in Iron Overload

(2008) Xueshan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deferiprone Does Not Protect against Chronic Anthracycline Cardiotoxicity in Vivo

(2008) O. Popelova et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2

(2008) P. N. Paradkar et al.   MOLECULAR AND CELLULAR BIOLOGY

Iron-Overload–Related Disease inHFEHereditary Hemochromatosis

(2008) Katrina J. Allen et al.   NEW ENGLAND JOURNAL OF MEDICINE