Article
Biochemistry & Molecular Biology
Shanelle Shillingford, Lei Zhang, Yulia Surovtseva, Sam Dorry, Elias Lolis, Anton M. Bennett
Summary: This study demonstrates the importance of a specific site (Y271) in the phosphatase domain of MKP7 for its catalytic activity and binding to p38 MAPK and JNK. Mutations in this site inhibited MKP7 function, leading to increased nuclear accumulation of p38 MAPK and JNK. These findings contribute to our understanding of the regulatory mechanisms of MKP7 and provide insights for potential therapeutic targeting of MKP7.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Savanie Fernando, Jacob Sellers, Shauri Smith, Sarayu Bhogoju, Sadie Junkins, Morgan Welch, Orion Willoughby, Nabin Ghimire, Cassandra Secunda, Marina Barmanova, Sean C. Kumer, Kisuk Min, Ahmed Lawan
Summary: This study reveals the upregulation of MKP-2 in liver tissue of obese and fatty liver disease patients and in insulin-responsive tissues of obese mice. MKP-2 deficiency in mice protects against diet-induced obesity and hepatic steatosis and is accompanied by improved glucose homeostasis and insulin sensitivity.
Article
Biochemistry & Molecular Biology
Hong Seok Kim, Yun Hee Kang, Jisu Lee, Seung Ro Han, Da Bin Kim, Haeun Ko, Seyoun Park, Myung-Shin Lee
Summary: Hypoxia, a characteristic of the tumor microenvironment, induces the activation of HIF-1 alpha through factors like MAPK. MKP-3, a phosphatase specific to Erk1/2, plays a role in regulating HIF-1 alpha levels in hypoxic colon cancer cells, potentially serving as a therapeutic target for colon cancer treatment.
MOLECULES AND CELLS
(2021)
Article
Cardiac & Cardiovascular Systems
Yun Liu, Jing Hu, Weiwei Wang, Qian Wang
Summary: This study explored the effect of miR-145 on cardiac fibrosis in heart failure mice and its target gene MAP3K3. The levels of miR-145 were decreased in heart failure mice and Ang II-treated cardiac fibroblasts. Upregulation of miR-145 improved cardiac dysfunction and inhibited fibrosis by suppressing MAP3K3 expression. Blocking MAP3K3 or upregulating miR-145 can be potential treatments for heart failure and cardiac fibrosis.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jeong Hyeon Lee, Myoung Eun Choi, Hongchan An, Ju Won Moon, Hye Jin Yeo, Youngsup Song, Sung Eun Chang
Summary: BCI-215 effectively inhibits melanogenesis by suppressing the expression of microphthalmia-associated transcription factor (MITF) and its downstream enzymes. This study provides a new therapeutic strategy for treating pigmentation disorders using DUSP-related signaling modulators.
Article
Multidisciplinary Sciences
Hui Lin, Muyang Wang, Ying Chen, Kinya Nomura, Shugang Hui, Jinshan Gui, Xiawei Zhang, Yue Wu, Jiyun Liu, Qun Li, Yiwen Deng, Laigeng Li, Meng Yuan, Shiping Wang, Sheng Yang He, Zuhua He
Summary: This study identifies a vascular defense mechanism in plants against bacterial pathogens and reveals a tissue-specific defense regulatory network.
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Review
Biochemistry & Molecular Biology
Fatma Zohra Khoubai, Christophe F. Grosset
Summary: Mitogen-activated protein kinases (MAPKs) are crucial for cell functioning, with DUSP9 playing a significant role in regulating MAPK activity. Dysregulation of MAPKs by phosphatases like DUSP9 can lead to various human pathologies, emphasizing the importance of careful regulation in maintaining proper cell functioning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ines da Silva, Sean Gullette, Cristina Florindo, Neil K. Huang, Thomas Neuberger, A. Catharine Ross, Graca Soveral, Rita Castro
Summary: Ketogenic diets may impact the expression of aquaporins in atherosclerosis models and these aquaporins are related to energy metabolism and fat accumulation.
Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Woonghee Lee, Gwonhwa Song, Hyocheol Bae
Summary: Recent studies have identified obesity as one of the world's most serious chronic disorders. The regulation of adipogenesis through inhibiting adipogenic differentiation and reactive oxygen species (ROS) production has been selected as a strategy to treat obesity. Fraxetin, a major component extracted from the stem barks of Fraxinus rhynchophylla, has many bioactivities. The effects of fraxetin on adipogenesis and ROS production involve mitogen-activated protein kinase (MAPK) signaling pathways.
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Biochemistry & Molecular Biology
Kira V. V. Derkach, Maxim A. A. Gureev, Anastasia A. A. Babushkina, Vladimir N. N. Mikhaylov, Irina O. O. Zakharova, Andrey A. A. Bakhtyukov, Viktor N. N. Sorokoumov, Alexander S. S. Novikov, Mikhail Krasavin, Alexander O. O. Shpakov, Irina A. A. Balova
Summary: This article describes the identification of dual inhibitors of protein phosphotyrosine phosphatase 1B (PTP1B)/T-cell protein phosphotyrosine phosphatase (TC-PTP) based on the 3-(hydroxymethyl)-4-oxo-1,4-dihydrocinnoline scaffold. The compounds were evaluated for their effects on obesity-related parameters and gene expressions. The results indicate the potential of these compounds as dual inhibitors for the treatment of metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Chang-Ning Fu, Jia-Wen Song, Zhi-Peng Song, Qian-Wen Wang, Wen-Wu Bai, Tao Guo, Peng Li, Chao Liu, Shuang-Xi Wang, Bo Dong
Summary: Statin-induced skeletal injury is mediated by the excessive expression of miR-1a, leading to decreased MAP3K1 gene expression and subsequent apoptosis of skeletal muscle cells.
Article
Biochemistry & Molecular Biology
Chao Huang, Huan Gong, Bin Mu, Xinting Lan, Chengcheng Yang, Jinlong Tan, Wentao Liu, Yuanfeng Zou, Lixia Li, Bin Feng, Xia He, Qihui Luo, Zhengli Chen
Summary: The barrier-to-autointegration factor-like protein (BAF-L) plays an important role in spermiogenesis and spermatozoal function. Its genetic deletion in mice impairs spermiogenesis and male fertility, and reduced testicular expression of BAF-L is a risk factor for human male infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xie Peng, Xuelin Cai, Jian Li, Yingyan Huang, Hao Liu, Jiaqi He, Zhengfeng Fang, Bin Feng, Jiayong Tang, Yan Lin, Xuemei Jiang, Liang Hu, Shengyu Xu, Yong Zhuo, Lianqiang Che, De Wu
Summary: The study found that dietary supplementation of melatonin during pregnancy can increase placental weight, reduce the proportion of piglets born with lower birth weight, and improve maternal-placental-fetal redox status and reproductive performance. Additionally, dietary melatonin can enhance placental antioxidant status, inflammatory response, and mitochondrial function.
Article
Biochemistry & Molecular Biology
Peng Wang, Peiqiang Yuan, Sen Lin, Heju Zhong, Xiaoling Zhang, Yong Zhuo, Jian Li, Lianqiang Che, Bin Feng, Yan Lin, Shengyu Xu, De Wu, Douglas G. Burrin, Zhengfeng Fang
Summary: This study investigated the intercorrelation between reproductive hormones and bile acids in pregnant sows and their fetuses. The newly identified PM4S and PM5S were found to be correlated with maternal and fetal bile acid homeostasis. The study confirmed the role of PM5S and PM4S as antagonists in bile acid homeostasis and FGF19 using pig hepatocytes. The pregnant sow is a promising animal model to study the pathogenesis of cholestasis during pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Yong Zhuo, Pu Yang, Lun Hua, Lei Zhu, Xin Zhu, Xinfa Han, Xiaoxue Pang, Shengyu Xu, Xuemei Jiang, Yan Lin, Lianqiang Che, Zhengfeng Fang, Bin Feng, Jianping Wang, Jian Li, De Wu, Jiankui Huang, Chao Jin
Summary: This study found that using MC or MW in feed can decrease the growth rate of gilts, reduce the number of ovarian follicles, and have an impact on ovarian function and oxidative status.
Article
Agriculture, Dairy & Animal Science
Li Zhe, Rui Zhou, Peter Kappel Theil, Uffe Krogh, Lunxiang Yang, Yong Zhuo, Yan Lin, Shengyu Xu, Xuemei Jiang, Lingjie Huang, Lianqiang Che, Bin Feng, De Wu, Zhengfeng Fang
Summary: This study compares the effects of a high-quality diet and a flavor plus multi-enzyme diet on the feed intake, nutrient digestibility, and antioxidant capacity of lactating sows and the growth of their progeny. Both diets improved sow feed digestibility and piglet growth, but the flavor plus multi-enzyme diet also improved the antioxidant capacity and health of sows. Dietary supplementation with flavor and multi-enzymes may be more promising than a high-quality diet from a health and economic perspective.
Article
Agriculture, Dairy & Animal Science
Xuecai Hu, Bin Huo, Jiameng Yang, Kun Wang, Lingjie Huang, Lianqiang Che, Bin Feng, Yan Lin, Shengyu Xu, Yong Zhuo, Caimei Wu, De Wu, Zhengfeng Fang
Summary: This study investigated the effects of different standardized ileal digestible (SID) Lys levels on the growth performance, nutrient digestibility, serum metabolites, and carcass and meat traits of Baqing pigs. The results showed that adding dietary SID Lys benefitted the growth phase of Baqing pigs, improving feed intake, gain to feed ratio, and average daily gain. The study also found that increasing dietary Lys levels increased the serum concentrations of triglycerides, lysine, and histidine. The optimal SID Lys requirement for Baqing pigs fed corn-soybean meal-based diets was estimated to be 0.92%, 0.66%, and 0.55% for different weight ranges. This study provides important insights into the nutritional requirements and feed formulation for Baqing pigs.
Article
Agriculture, Dairy & Animal Science
Yan Lin, Chenglong Yu, Zhao Ma, Lianqiang Che, Bin Feng, Zhengfeng Fang, Shengyu Xu, Yong Zhuo, Jian Li, Junjie Zhang, Min Yang, Peng Chen, De Wu
Summary: The use of corn-soybean meal feed and yeast culture supplementation in growing-finishing pigs can improve growth performance, meat quality, and gut health. Corn-soybean meal feed and yeast culture can reduce feed cost, increase dressing percentage, and improve meat color, as well as enhance antioxidant capacity and balance intestinal microbiota.
Article
Agriculture, Dairy & Animal Science
Fangyuan Chen, Lunxiang Yang, Li Zhe, Maamer Jlali, Yong Zhuo, Xuemei Jiang, Lingjie Huang, Fali Wu, Ruinan Zhang, Shengyu Xu, Yan Lin, Lianqiang Che, Bin Feng, De Wu, Aurelie Preynat, Zhengfeng Fang
Summary: The supplementation of multi-carbohydrase and phytase can improve digestibility and nutrient utilization in fattening pigs, leading to increased growth rate and feed efficiency. These findings have important implications for cost-saving, minimizing nutrient waste, and improving swine production efficiency.
Article
Biochemistry & Molecular Biology
Xiaohua Huang, Heng Zhu, Wei Lu, Lei Cao, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Yong Zhuo, Lun Hua, Xuemei Jiang, Mengmeng Sun, De Wu, Bin Feng
Summary: The mechanism by which acute endoplasmic reticulum (ER) stress suppresses hepatic gluconeogenesis is unclear. This study found that MAPK phosphatase 3 (MKP-3) plays a positive regulatory role in this process. Acute ER stress inhibits hepatic gluconeogenesis by degrading MKP-3. Therefore, MKP-3 may be a therapeutic target for drug-induced liver injury (DILI)-related hypoglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Yaxue Cao, Min Yang, Jie Song, Xuemei Jiang, Shengyu Xu, Lianqiang Che, Zhengfeng Fang, Yan Lin, Chao Jin, Bin Feng, De Wu, Lun Hua, Yong Zhuo
Summary: FGF21, a hormone released in the liver, has been identified as an important endocrine signal for dietary protein intake. This study investigated the role of FGF21 and hypothalamic changes in controlling estrous cyclicity by dietary protein intake. The research found that severe dietary protein restriction resulted in the cessation of estrous cyclicity and ovarian follicle development, and hepatic FGF21 and hypothalamic Kiss-1 were partially required for this process.
Article
Agriculture, Dairy & Animal Science
Yuwei Zhang, Qiang Zhou, Shiya Liu, Xiang Quan, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Yong Zhuo, De Wu, Lianqiang Che
Summary: The study found that partially substituting whey protein concentrate with spray-dried porcine plasma in milk replacer for neonatal piglets can improve growth performance and intestinal morphology, increase digestive enzyme activity, and reduce pathogenic bacteria.
Article
Biochemistry & Molecular Biology
Guangrong Xie, Qipeng Zhang, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Yong Zhuo, Lun Hua, Xuemei Jiang, Jian Li, Mengmeng Sun, Yuanfeng Zou, Chao Huang, Lixia Li, De Wu, Bin Feng
Summary: This study found that excessive intake of oxidized fat during pregnancy and lactation can harm both the mother's body and the health of their offspring. However, supplementation of vitamin D and inulin during pregnancy and lactation can mitigate these damages.
Review
Microbiology
Feng Qin, Wenyan Wei, Junjie Gao, Xuemei Jiang, Lianqiang Che, Zhengfeng Fang, Yan Lin, Bin Feng, Yong Zhuo, Lun Hua, Jianping Wang, Mengmeng Sun, De Wu, Shengyu Xu
Summary: Dietary fiber is a substance that cannot be digested by endogenous digestive enzymes but can be digested by intestinal microorganisms. In recent years, it has gained increasing attention due to its functional properties, potential health benefits to animals, and fermentability. Research suggests that dietary fiber can provide energy for pigs through intestinal microbial fermentation, improve sow welfare and reproductive performance, regulate intestinal flora, and enhance immunity.
Letter
Biochemistry & Molecular Biology
Bharathiraja Subramaniyan, Jason L. Larabee, Manish Bodas, Andrew R. Moore, Anthony W. G. Burgett, James F. Papin, Matthew S. Walters
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Manish Bodas, Bharathiraja Subramaniyan, Harry Karmouty-Quintana, Peter F. Vitiello, Matthew S. Walters
Summary: The lung, as the respiratory organ of mammals, plays a crucial role in gas exchange and is regulated by the NOTCH signaling pathway. Notably, dysregulation of NOTCH3 signaling is associated with the development and pathophysiology of various adult lung diseases.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
