Article
Biochemistry & Molecular Biology
Qiuchi Chen, Wei Fang, Yanan Shen, Dan Xu, Qiang Chen, Kun Cui, Kangsen Mai, Qinghui Ai
Summary: This study found that the deficiency of Cideb alone does not trigger severe inflammation in the liver. However, under ER stress, the expression of Cideb is suppressed by Chop, which inhibits the transport of lipoproteins in the liver, leading to exacerbated hepatic steatosis, oxidative stress, and inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Helena Leal, Joao Cardoso, Patricia Valerio, Marta Quatorze, Vitor Carmona, Janete Cunha-Santos, Luis Pereira de Almeida, Claudia Pereira, Claudia Cavadas, Pedro Gomes
Summary: The protein SIRT2 is found to play a role in the regulation of hepatic lipid metabolism and its activation might be a therapeutic strategy against obesity and its metabolic complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qiuchi Chen, Wei Fang, Kun Cui, Qiang Chen, Xiaojun Xiang, Junzhi Zhang, Yunqiang Zhang, Kangsen Mai, Qinghui Ai
Summary: The study revealed that ER stress can promote lipid droplets accumulation and inhibit lipoprotein transport by transcriptionally upregulating PLIN2 in the liver, providing insight into a novel mechanism for ER stress-induced hepatic steatosis.
Article
Nutrition & Dietetics
Khrystyna Platko, Paul F. Lebeau, Joshua P. Nederveen, Jae Hyun Byun, Melissa E. MacDonald, Jacqueline M. Bourgeois, Mark A. Tarnopolsky, Richard C. Austin
Summary: Metabolic syndrome affects a large number of individuals worldwide and is a major cause of health problems. Obesity is at the core of metabolic abnormalities associated with MetS. This study found that a metabolic enhancer composed of seven naturally occurring antioxidants and mitochondrial enhancing agents improved obesity, hepatic steatosis, and atherogenic serum profile in mice. The findings suggest that the components of the metabolic enhancer have a positive, protective effect on obesity, hepatic steatosis, and cardiovascular risk similar to exercise training.
Article
Cell Biology
Kamrul M. Hasan, Meher Parveen, Alondra Pena, Francisco Bautista, Juan Carlos Rivera, Roxana Ramirez Huerta, Erica Martinez, Jorge Espinoza-Derout, Amiya P. Sinha-Hikim, Theodore C. Friedman
Summary: CARF regulates cellular fate in response to stresses, including metabolic stress. Low CARF expression was observed in fatty livers and overloaded palmitate inhibited CARF expression in HepG2 cells. Silencing and overexpressing CARF affected fat accumulation in HepG2 cells, and CARF overexpression reduced ectopic palmitate accumulation. Transcriptome analysis revealed dysregulation of ER stress and oxidative stress pathway genes in CARF-deficient cells. Overexpression of CARF in mice alleviated hepatic steatosis, ER dysfunction, oxidative stress, and insulin resistance induced by excess fat. Overall, excess fat-induced reduction of CARF dysregulates ER function and lipid metabolism leading to hepatic steatosis.
Article
Biochemistry & Molecular Biology
Dan Wang, Rihua Zhang, Xiaoxuan Qin, Jizheng Wang, Yifang Hu, Shan Lu, Jingbao Kan, Yaoqi Ge, Ke Jin, Wen-Song Zhang, Yun Liu
Summary: Alcoholic liver disease (ALD) is a range of diseases from simple steatosis to cirrhosis and liver cancer. S100A16, a protein related to lipid metabolism, has been found to be elevated in ALD patients and in a mouse model. Knocking out S100a16 gene alleviates ethanol-induced liver injury and inflammation, while overexpression of S100a16 exacerbates these effects. Mechanistically, the downstream regulated entity MANF inhibits ER-stress signal transduction induced by alcohol stimulation. Overall, this study suggests that S100a16 deletion protects against alcoholic liver lipid accumulation and inflammation by upregulating MANF and inhibiting ER stress.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Food Science & Technology
Suzuka Uomoto, Keisuke Takesue, Saori Shimizu, Natsuno Maeda, Kanami Oshima, Emika Hara, Mio Kobayashi, Yasunori Takahashi, Makoto Shibutani, Toshinori Yoshida
Summary: We investigated the role of ER-phagy in NAFLD-related hepatocarcinogenesis in HFD-fed and/or PB-treated rats by clustering the expression levels of p62 and FAM134B in preneoplastic hepatic lesions. The results showed that PB administration increased clusters with high levels of p62, while HFD feeding increased clusters with high levels of both p62 and FAM134B. The combination of HFD feeding with PB counteracted each other's effects and the cluster composition resembled that of the control group.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Samah Alharbi
Summary: Reducing the circulatory ratio of AG/UAG by exogenous administration of UAG can attenuate HFD-induced hepatic steatosis through multiple mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Agriculture, Dairy & Animal Science
Bi-Chen Zhao, Yi-Xi Tang, Bai-Hao Qiu, Hao-Liang Xu, Tian-Hao Wang, Ahmed Ibrahim Ahmed Elsherbeni, Hassan Bayoumi Ali Gharib, Jin-Long Li
Summary: Transport stress can disrupt hepatic glucolipid metabolism, but Astragalus polysaccharide (APS) may counteract this through modulation of stress levels, lipid metabolism, gluconeogenesis, and glycogenolysis. APS demonstrated potential in alleviating transport stress-induced lipid deposition and disturbances in glucose metabolism.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Paul Manka, Svenja Sydor, Nishikant Wase, Jan Best, Malte Brandenburg, Annika Hellbeck, Julia Schanzer, Ramiro Vilchez-Vargas, Alexander Link, Anja Figge, Andreas Jahnert, Ulrike von Arnim, Jason D. Coombes, Francisco-Javier Cubero, Alisan Kahraman, Moon-Sung Kim, Julia Kalsch, Sonja Kinner, Klaas-Nico Faber, Han Moshage, Guido Gerken, Wing-Kin Syn, Scott L. Friedman, Ali Canbay, Lars P. Bechmann
Summary: In this study, the potential relationship between anti-TNF treatment and hepatic steatosis in Crohn's disease was analyzed. Patients on anti-TNF treatment showed reduced hepatic steatosis, higher serum FGF19 levels, and lower levels of neutral lipids such as triglycerides. The abundance of Firmicutes, bacteria involved in bile acid metabolism and FGF19 regulation, was associated with triglyceride levels and showed group-specific alterations.
LIVER INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Chang-Hai Liu, Shanshan Zheng, Shisheng Wang, Dongbo Wu, Wei Jiang, Qingmin Zeng, Yi Wei, Yong Zhang, Hong Tang
Summary: Ceruloplasmin and ORM1 may serve as potential biomarkers in distinguishing mild and severe steatosis in MAFLD patients.
Article
Multidisciplinary Sciences
Gunes Parlakgul, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Guney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, Gokhan S. Hotamisligil
Summary: This study reveals the complex structural organization of organelles in liver tissue and highlights the significant alterations in obese mice. The functional importance of these structural changes on cellular and systemic metabolism is also demonstrated.
Review
Biochemistry & Molecular Biology
Ashley K. Putman, G. Andres Contreras, Emilio P. Mottillo
Summary: Metabolic diseases have negative health outcomes and are associated with dysregulated energy metabolism. Adipose tissue plays a crucial role in energy homeostasis and utilizes redox reactions for metabolism. Non-shivering thermogenesis, a highly oxidative process, can enhance energy expenditure and may have beneficial effects on metabolic health. However, targeting the redox mechanisms of adipose tissue as a therapeutic approach for metabolic disease remains understudied.
Article
Pharmacology & Pharmacy
Sahebgowda Sidramagowda Patil, Ramani Soundararajan, Jutaro Fukumoto, Mason Breitzig, Helena Hernandez-Cuervo, Matthew Alleyn, Muling Lin, Venkata Ramireddy Narala, Richard Lockey, Narasaiah Kolliputi, Lakshmi Galam
Summary: High concentrations of supplementary oxygen are used to treat acute lung injury and acute respiratory distress syndrome, but prolonged exposure can lead to mitochondrial damage and protein misfolding in the endoplasmic reticulum. Akap1 plays a critical role in maintaining mitochondrial homeostasis, and its deficiency exacerbates lung injury. Deleting Akap1 increases ER stress in response to hyperoxia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jicheng Han, Cheng Cheng, Jinxin Zhang, Jinbo Fang, Wei Yao, Yilong Zhu, Zhiru Xiu, Ningyi Jin, Huijun Lu, Xiao Li, Yiquan Li
Summary: In this study, it was found that myricetin inhibits the activation of pyroptosis in lung cancer cells by cleaving GSDME. It was also found that myricetin induces endoplasmic reticulum stress and increases reactive oxygen species levels, leading to the inhibition of pyroptosis. In vivo experiments showed that myricetin reduces tumor volume and increases pyroptosis-related protein levels in tumor tissues.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Hyo Jeong Kim, Yeonsoo Joe, Yingqing Chen, Gyu Hwan Park, Uh-Hyun Kim, Hun Taeg Chung
Article
Biochemistry & Molecular Biology
Min Zheng, Yubing Chen, Jeongmin Park, Hyun-Chul Song, Yingqing Chen, Jeong Woo Park, Yeonsoo Joe, Hun Taeg Chung
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Cell Biology
Yeonsoo Joe, Yingqing Chen, Jeongmin Park, Hyo Jeong Kim, So-Young Rah, Jinhyun Ryu, Gyeong Jae Cho, Hye-Seon Choi, Stefan W. Ryter, Jeong Woo Park, Uh-Hyun Kim, Hun Taeg Chung
Article
Biochemistry & Molecular Biology
Jeongmin Park, Jin Kim, Yingqing Chen, Hyun-Chul Song, Yubing Chen, Min Zheng, Young-Joon Surh, Uh-Hyun Kim, Jeong Woo Park, Yeonsoo Joe, Hun Taeg Chung
FREE RADICAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Hyun-Chul Song, Yubing Chen, Yingqing Chen, Jeongmin Park, Min Zheng, Young-Joon Surh, Uh-Hyun Kim, Jeong Woo Park, Rina Yu, Hun Taeg Chung, Yeonsoo Joe
FREE RADICAL RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Sena Kim, Srikanth Santhanam, Sora Lim, Jaebok Choi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Letter
Oncology
Sena Kim, Kidist Ashami, Sora Lim, Karl Staser, Kiran Vij, Srikanth Santhanam, Julie Ritchey, Sarah Peterson, Feng Gao, Matthew A. Ciorba, Matthew L. Cooper, John F. DiPersio, Jaebok Choi
Review
Cell Biology
Yingqing Chen, Shuo Yuan, Yuying Cao, Guangyao Kong, Feng Jiang, You Li, Qi Wang, Minli Tang, Qinggao Zhang, Qianqian Wang, Liping Liu
Summary: Fibrosis is the pathological progress of excessive extracellular matrix deposition due to inadequate regenerative capacity of cells, characterized by excessive activated and proliferated fibroblasts, differentiation of fibroblasts into myofibroblasts, and epithelial-mesenchymal transition. Mechanistically, activations of TGF-beta signaling pathway, oxidative stress, cellular senescence, and inflammatory response are crucial in fibroblast activation and ECM generation.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Yingqing Chen, Feng Jiang, Guangyao Kong, Shuo Yuan, Yuying Cao, Qinggao Zhang, Qianqian Wang, Liping Liu
Summary: Cellular senescence is a phenomenon where proliferative cells undergo permanent growth arrest, potentially leading to diseases and physiological decline. Plasminogen activator inhibitor (PAI-1) is considered a critical regulator of senescence, and exogenous carbon monoxide (CO) has been shown to inhibit senescence by inducing stress granule (SG) formation. The study demonstrated that CO-induced SGs could protect against DNA damage-induced senescence in lung fibroblasts by sequestering PAI-1, suggesting a novel role of CO in suppressing cellular senescence.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Uh-Hyun Kim
Summary: In this review, the roles of cADPR and NAADP in pancreatic beta cells are summarized, along with the intracellular Ca2+ stores and Ca2+ channels they target. Studying the roles of these signaling messengers helps us understand Ca2+ signaling and pathophysiology.
Review
Cell Biology
Yingqing Chen, Minli Tang, Shuo Yuan, Shuang Fu, Yifei Li, You Li, Qi Wang, Yuying Cao, Liping Liu, Qinggao Zhang
Summary: Cardiovascular diseases, such as hyperlipidemia, thick blood, atherosclerosis, and hypertension, are a serious threat to human health. Rhodiola rosea, a traditional Chinese medicine, has been found to have pharmacological effects such as reducing blood fat, inhibiting thrombosis, and preventing arrhythmia, making it valuable in the treatment of cardiovascular diseases.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Hematology
Sena Kim, Sora Lim, Boram Kim, Julie Ritchey, Kiran Vij, Julie Prior, Lynne Marsala, Alyssa Stoner, Feng Gao, Samuel Achilefu, Matthew L. Cooper, John F. DiPersio, Jaebok Choi
Summary: By blocking the IFNGR signaling pathway, S100A9 is upregulated in T cells and acts as a novel suppressor of graft-versus-host disease (GVHD) while preserving graft-versus-leukemia (GVL) effects. In both mouse models of allo-HSCT and xenogeneic human peripheral blood mononuclear cell transplantation, overexpression of S100A9 or administration of anti-IFNGR antibody improved GVHD without compromising GVL and reduced T-cell trafficking to GVHD target organs.
Editorial Material
Hematology
Sena Kim, Jaebok Choi
Summary: This study demonstrates that the activation of TGF-beta 1 by Tregs through GARP downregulates the effector functions of NK cells in the bone marrow of AML patients with early relapse after allo-HCT, and that blocking TGF-beta 1 signaling can restore the killer instinct of human NK cells.
Article
Medicine, Research & Experimental
Stephen P. Persaud, Julie K. Ritchey, Sena Kim, Sora Lim, Peter G. Ruminski, Matthew L. Cooper, Michael P. Rettig, Jaebok Choi, John F. DiPersio
Summary: The study demonstrates that using ADC conditioning in mice can achieve robust multilineage allogeneic engraftment. Mechanistic studies of JAK1/2 inhibition revealed impairments in T and NK cell survival, proliferation, and effector function. The combination of ADCs and baricitinib balanced graft-versus-host disease and graft-versus-leukemia responses.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Chemistry, Physical
Qianqian Wang, Qinggao Zhang, Elaine Lai Han Leung, Yingqing Chen, Xiaojun Yao
Summary: This study applied integrated molecular dynamics techniques to investigate the characteristics of 5-iTU and its derivatives targeting haspin, revealing the crucial role of 5-iTU in binding with haspin and the importance of gatekeeper Phe605.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)