STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications
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Title
STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications
Authors
Keywords
STAT3 transcription factor, Protein processing, Post-translational, Adenosine triphosphate, Lipid metabolism, Metabolism, Neoplasms
Journal
NEOPLASIA
Volume 23, Issue 12, Pages 1167-1178
Publisher
Elsevier BV
Online
2021-10-29
DOI
10.1016/j.neo.2021.10.003
References
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Note: Only part of the references are listed.- Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid–coated Layer-by-Layer Nanoparticles
- (2021) Isidora Tošić et al. MOLECULAR CANCER THERAPEUTICS
- The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
- (2020) Yuqing Wu et al. Molecular Cancer
- 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6–JAK–STAT3 Signaling in Prostate Cancer Cells
- (2020) Shweta Dambal et al. MOLECULAR CANCER RESEARCH
- Energy Metabolism in Cancer: The Roles of STAT3 and STAT5 in the Regulation of Metabolism-Related Genes
- (2020) Arturo Valle-Mendiola et al. Cancers
- A Potential Nutraceutical Candidate Lactucin Inhibits Adipogenesis through Downregulation of JAK2/STAT3 Signaling Pathway-Mediated Mitotic Clonal Expansion
- (2020) Xin Wang et al. Cells
- Inhibition of JAK2/STAT3/SOCS3 signaling attenuates atherosclerosis in rabbit
- (2020) Xilan Yang et al. BMC Cardiovascular Disorders
- Adipocytes promote tumor progression and induce PD-L1 expression via TNF-α/IL-6 signaling
- (2020) Zhi Li et al. Cancer Cell International
- Phase 1 study of napabucasin, a cancer stemness inhibitor, in patients with advanced solid tumors
- (2020) Akihito Kawazoe et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation
- (2020) Jesse J. Balic et al. CYTOKINE
- STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
- (2020) Jesse J. Balic et al. Nature Communications
- A metastasis map of human cancer cell lines
- (2020) Xin Jin et al. NATURE
- STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis
- (2020) Wei-Hsin Lin et al. ONCOGENE
- Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM)
- (2020) Moshe Lapidot et al. Cancers
- STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction
- (2020) Lara Brambilla et al. iScience
- HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance
- (2019) Ayako Nagao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer
- (2019) Wanming He et al. ONCOGENE
- SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle
- (2019) Young Do Koo et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Mapping and Profiling Lipid Distribution in a 3D Model of Breast Cancer Progression
- (2019) Netta Vidavsky et al. ACS Central Science
- Napabucasin (BBI608) eliminate AML cells in vitro and in vivo via inhibition of Stat3 pathway and induction of DNA damage
- (2019) Silei Bi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Adipocyte and lipid metabolism in cancer drug resistance
- (2019) Yihai Cao JOURNAL OF CLINICAL INVESTIGATION
- Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells
- (2019) Dongfeng Han et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Critical appraisal of STAT3 pattern in adult cardiomyocytes
- (2019) Zeina Harhous et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity
- (2019) Jesse Balic et al. CANCER RESEARCH
- IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in 1q21(amp) multiple myeloma
- (2019) Phaik Ju Teoh et al. HAEMATOLOGICA
- Causes and Consequences of A Glutamine Induced Normoxic HIF1 Activity for the Tumor Metabolism
- (2019) Matthias Kappler et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Molecular Links between Central Obesity and Breast Cancer
- (2019) Zimta et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Niclosamide reverses adipocyte induced epithelial-mesenchymal transition in breast cancer cells via suppression of the interleukin-6/STAT3 signalling axis
- (2019) Jones Gyamfi et al. Scientific Reports
- IL-17A promotes fatty acid uptake through the IL-17A/IL-17RA/p-STAT3/FABP4 axis to fuel ovarian cancer growth in an adipocyte-rich microenvironment
- (2019) Chunyan Yu et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway
- (2019) Peng Gao et al. LIFE SCIENCES
- Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity
- (2019) Tao Su et al. PHARMACOLOGICAL RESEARCH
- Direct Targeting Options for STAT3 and STAT5 in Cancer
- (2019) Anna Orlova et al. Cancers
- In Chronic Lymphocytic Leukemia the JAK2/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment
- (2019) Severin et al. Cancers
- The role of STAT3 in leading the crosstalk between human cancers and the immune system
- (2018) Yu Wang et al. CANCER LETTERS
- JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance
- (2018) Tianyi Wang et al. Cell Metabolism
- High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling
- (2018) Takuji Hayashi et al. CLINICAL CANCER RESEARCH
- STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cells
- (2018) Yuying Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Blocking of STAT-3/ SREBP1-mediated glucose–lipid metabolism is involved in dietary phytoestrogen-inhibited ovariectomized-induced body weight gain in rats
- (2018) Juan Chen et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Targeting the IL-6/JAK/STAT3 signalling axis in cancer
- (2018) Daniel E. Johnson et al. Nature Reviews Clinical Oncology
- A First‐in‐Human Phase I Study of OPB‐111077, a Small‐Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers
- (2018) Anthony Tolcher et al. ONCOLOGIST
- LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect
- (2018) Shaoxun Xiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- STAT3: The art of multi-tasking of metabolic and immune functions in obesity
- (2018) Wei Hu et al. PROGRESS IN LIPID RESEARCH
- Adipocytes affect castration-resistant prostate cancer cells to develop the resistance to cytotoxic action of NK cells with alterations of PD-L1/NKG2D ligand levels in tumor cells
- (2018) Lijun Xu et al. PROSTATE
- Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis
- (2018) Rohollah Babaei et al. Science Signaling
- Interleukin-6/STAT3 signalling regulates adipocyte induced epithelial-mesenchymal transition in breast cancer cells
- (2018) Jones Gyamfi et al. Scientific Reports
- Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis
- (2018) Rohollah Babaei et al. Science Signaling
- The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells
- (2018) Susana P. Egusquiaguirre et al. NEOPLASIA
- Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression
- (2018) Jin-Yong He et al. Cell Communication and Signaling
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- (2017) K Kondo et al. LEUKEMIA
- Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition
- (2017) Bernd Groner et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
- (2017) Thomas Farge et al. Cancer Discovery
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- (2016) Erica M. Bullwinkle et al. CANCER LETTERS
- Mitochondrial Stat3, the Need for Design Thinking
- (2016) Rui Yang et al. International Journal of Biological Sciences
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- (2016) Kaiyan Liu et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
- (2016) Roman Camarda et al. NATURE MEDICINE
- SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer
- (2016) Z Zhou et al. ONCOGENE
- Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer
- (2016) Q Qu et al. Cell Death & Disease
- JNK1/2 expression and modulation of STAT3 signaling in oral cancer
- (2016) IOANNIS GKOUVERIS et al. Oncology Letters
- Icaritin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling
- (2016) Jinfeng Wu et al. Oncotarget
- A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
- (2016) Marco Demaria et al. Aging-US
- Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion
- (2015) Chunhua Yu et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: Overview and application
- (2015) Yukie Yoshii et al. CANCER LETTERS
- Cancer cell metabolism and developmental homeodomain/POU domain transcription factors: A connecting link
- (2015) Biswa Pratim Das Purkayastha et al. CANCER LETTERS
- STAT3-Interacting Proteins as Modulators of Transcription Factor Function: Implications to Targeted Cancer Therapy
- (2015) Jennifer E. Yeh et al. ChemMedChem
- STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer
- (2015) Joseph D Fleming et al. Epigenetics & Chromatin
- STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance
- (2015) Valeria Poli et al. Frontiers in Oncology
- Multiple regulation pathways and pivotal biological functions of STAT3 in cancer
- (2015) Jie Yuan et al. Scientific Reports
- S-Glutathionylation at Cys328 and Cys542 Impairs STAT3 Phosphorylation
- (2014) Elena Butturini et al. ACS Chemical Biology
- STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation
- (2014) D. J. Gough et al. BLOOD
- Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer
- (2014) Heba Alshaker et al. BREAST CANCER RESEARCH AND TREATMENT
- Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells
- (2014) Ho-June Lee et al. CANCER CELL
- Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling
- (2014) Irfan J. Lodhi et al. Cell Metabolism
- Fructose-1,6-bisphosphatase opposes renal carcinoma progression
- (2014) Bo Li et al. NATURE
- mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3
- (2014) K M Dodd et al. ONCOGENE
- STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b
- (2014) Sarah Walker et al. Cancers
- STAT3 Target Genes Relevant to Human Cancers
- (2014) Richard Carpenter et al. Cancers
- Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention
- (2014) Ailian Xiong et al. Cancers
- Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser727 on STAT3 in prostate cancer cells
- (2013) Fu-Ning Hsu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Lipid biology of breast cancer
- (2013) Jan Baumann et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells
- (2013) Eunhee Kim et al. CANCER CELL
- Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
- (2013) J. R. Doherty et al. CANCER RESEARCH
- p42/p44 MAPK-mediated Stat3Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth
- (2013) Mercedes Tkach et al. ENDOCRINE-RELATED CANCER
- Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727
- (2013) Qifang Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis
- (2013) A Berger et al. LEUKEMIA
- Distinct transcriptional regulatory modules underlie STAT3’s cell type-independent and cell type-specific functions
- (2013) Andrew Paul Hutchins et al. NUCLEIC ACIDS RESEARCH
- STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
- (2013) M R Pawlus et al. ONCOGENE
- Inhibition of Lipolysis by Mercaptoacetate and Etomoxir Specifically Sensitize Drug-Resistant Lung Adenocarcinoma Cell to Paclitaxel
- (2013) Jiajin Li et al. PLoS One
- The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation
- (2013) Daniel J. Gough et al. PLoS One
- Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages
- (2012) A. P. Hutchins et al. BLOOD
- JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic
- (2012) Bailing Chen et al. CELL CYCLE
- Lipid metabolism in cancer
- (2012) Claudio R. Santos et al. FEBS Journal
- From Macrophage Interleukin-13 Receptor to Foam Cell Formation
- (2012) Valentin P. Yakubenko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain
- (2012) Prasad Tammineni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role and Regulation of STAT3 Phosphorylation at Ser727 in Melanocytes and Melanoma Cells
- (2012) Masanobu Sakaguchi et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- The Stat3/GR Interaction Code: Predictive Value of Direct/Indirect DNA Recruitment for Transcription Outcome
- (2012) David Langlais et al. MOLECULAR CELL
- ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
- (2012) Weiwei Yang et al. NATURE CELL BIOLOGY
- Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation
- (2012) H. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multi-tasking: nuclear transcription factors with novel roles in the mitochondria
- (2012) Karol Szczepanek et al. TRENDS IN CELL BIOLOGY
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Enhanced Cancer Immunotherapy Using STAT3-Depleted Dendritic Cells with High Th1-Inducing Ability and Resistance to Cancer Cell-Derived Inhibitory Factors
- (2011) T. Iwata-Kajihara et al. JOURNAL OF IMMUNOLOGY
- NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
- (2011) Claudio Mauro et al. NATURE CELL BIOLOGY
- Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion
- (2010) Kerstin Boengler et al. BASIC RESEARCH IN CARDIOLOGY
- Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation
- (2010) K. Friedbichler et al. BLOOD
- STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells
- (2010) I. Hazan-Halevy et al. BLOOD
- Targeting Stat3 in the Myeloid Compartment Drastically Improves the In vivo Antitumor Functions of Adoptively Transferred T Cells
- (2010) A. Herrmann et al. CANCER RESEARCH
- Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis
- (2010) Lydia Durant et al. IMMUNITY
- STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: A potential for targeted therapy?
- (2010) Claire Villalva et al. INTERNATIONAL JOURNAL OF CANCER
- Protein kinase Cɛ mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2 and ERK1/2)
- (2010) M H Aziz et al. ONCOGENE
- Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
- (2010) A. Le et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor γ (PPARγ)
- (2009) Dongmei Wang et al. BIOLOGY OF THE CELL
- Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma
- (2009) S Takemoto et al. BRITISH JOURNAL OF CANCER
- Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors
- (2009) Heehyoung Lee et al. CANCER CELL
- Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation
- (2009) D. J. Gough et al. SCIENCE
- Function of Mitochondrial Stat3 in Cellular Respiration
- (2009) J. Wegrzyn et al. SCIENCE
- Activation of Signal Transducer and Activator of Transcription 3 through a Phosphomimetic Serine 727 Promotes Prostate Tumorigenesis Independent of Tyrosine 705 Phosphorylation
- (2008) H. R. Qin et al. CANCER RESEARCH
- Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
- (2008) Xi Chen et al. CELL
- Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival
- (2008) Chun-Liang Chen et al. Molecular Cancer
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