STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction

Phase Separation in Regulation of Aggrephagy

(2019) Daxiao Sun et al.   JOURNAL OF MOLECULAR BIOLOGY

Five decades of research on mitochondrial NADH-quinone oxidoreductase (complex I)

(2018) Tomoko Ohnishi et al.   BIOLOGICAL CHEMISTRY

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Signal Transducer and Activator of Transcription Protein 3 (STAT3): an Update on its Direct Inhibitors as Promising Anticancer Agents

(2018) Arianna Gelain et al.   CURRENT MEDICINAL CHEMISTRY

Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma

(2018) Changhoon Yoo et al.   Cancer Research and Treatment

Nucleus, Mitochondrion, or Reticulum? STAT3 à La Carte

(2018) Lidia Avalle et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Regulation Mechanisms and Interactions Between Reactive Oxygen Species and Mitophagy

(2018) Pan Fan et al.   DNA AND CELL BIOLOGY

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance

(2018) Jayshree Hirpara et al.   Redox Biology

Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors

(2018) Matilda Lee et al.   Redox Biology

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

(2017) Davide Genini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p62 in Cancer: Signaling Adaptor Beyond Autophagy

(2016) Jorge Moscat et al.   CELL

Intracellular pH Modulates Autophagy and Mitophagy

(2016) Alexey V. Berezhnov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

(2016) Marco Demaria et al.   Aging-US

Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies

(2015) A. L. Wong et al.   ANNALS OF ONCOLOGY

Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies

(2015) Michinori Ogura et al.   CANCER SCIENCE

A STAT inhibitor patent review: progress since 2011

(2015) Ping-Shan Lai et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3

(2015) Daniel J. Garama et al.   MOLECULAR AND CELLULAR BIOLOGY

Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)

(2015) Lara Brambilla et al.   Molecular Oncology

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Identification of STAT1 and STAT3 Specific Inhibitors Using Comparative Virtual Screening and Docking Validation

(2015) Malgorzata Szelag et al.   PLoS One

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation

(2014) D. J. Gough et al.   BLOOD

Glucose Controls Morphodynamics of LPS-Stimulated Macrophages

(2014) Gerda Venter et al.   PLoS One

Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727

(2013) Qifang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

(2012) C. Mantel et al.   BLOOD

The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain

(2012) Prasad Tammineni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-tasking: nuclear transcription factors with novel roles in the mitochondria

(2012) Karol Szczepanek et al.   TRENDS IN CELL BIOLOGY

The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3

(2011) M. Vogt et al.   JOURNAL OF CELL SCIENCE

Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3

(2011) Karol Szczepanek et al.   MITOCHONDRION

Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment

(2010) P. Kadandale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT3-Stathmin Interactions Control Microtubule Dynamics in Migrating T-cells

(2009) Navin K. Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Generation of ρ 0 cells utilizing a mitochondrially targeted restriction endonuclease and comparative analyses

(2008) Alexandra Kukat et al.   NUCLEIC ACIDS RESEARCH